Protein Alignment Ncc69 and SLC12A8

DIOPT Version :10

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: NP_078904.4
• Gene: SLC12A8 / 84561
• HGNCID: 15595
• Length: 714
• Species: Homo sapiens
• Alignment Length: 673
• Identity: 168/673 - (24%)
• Similarity: 266/673 - (39%)
• Gaps: 218/673 - (32%)

  Fly   212 FGWIKGVLVRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKG 276
            ||...||...|::||:||:||||..|:||..||:.|..|:.....|..:|.||...:.....|..
Human    39 FGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGS 103

  Fly   277 GGTYYMISRSLGPEFGGSIGLIFSLANAVACAMYVVGFCESMLAMMTTFGWEIIDGGVQDVRIIG 341
            ||.|.|||..||.:.||:|||::.....||.|||:.||.||:..::..       |.:..||.|.
Human   104 GGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLGL-------GNIWAVRGIS 161

  Fly   342 CITILLLLIIVVVGMEWEAKAQIGLLIILLVAIGDFVIGSFIGPKSDAEMAKGFLGYNATLFKNN 406
            ...:|.||.|.:.|::|..:.|:.||.:|.|:..|||:|||    :..:...||:||:..|.:||
Human   162 VAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSF----THLDPEHGFIGYSPELLQNN 222

  Fly   407 LFADYRPEKGGIQHDFFSVFAIFFPAATGILAGANISGDLKDPQKSIPKGTILAIVITTGTYLIM 471
            ...||.|.:     .||:||.:|||||||::||.|:.|||::|..|||.|::.|:.|:...|:|.
Human   223 TLPDYSPGE-----SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIIF 282

  Fly   472 VLQCGATVARDATGNLSDVVNGTFAFLDCQPGECNYGLQNSFQVIELVSAFGPLIYAGCYAATLS 536
            |...||...|:|                         |:..|.:.|.||..|.|...|.|.::|:
Human   283 VFLLGAICTREA-------------------------LRYDFLIAEKVSLMGFLFLLGLYISSLA 322

  Fly   537 SALASLVSAPKVFQALCKDELYPKIVWFAKGYGKNNEPVRGYVLTFIIACAFILIGELNLIAPLI 601
            |.:..|..||::.|.:.::::.|.:....:|.|.|..||....||.::..||:.:|::|::||::
Human   323 SCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIV 387

  Fly   602 SNFFLAAYMLINFSTFHASL--------------------------------------------- 621
            :..|:..|:.:::|.|..|:
Human   388 TINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPSYGSEGPAQRVLE 452

  Fly   622 ----------------------------------------------------------------- 621
                                                                             
Human   453 GTLLEFTKDMDQLLQLTRKLESSQPRQGEGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPV 517

  Fly   622 ---------------------------AKPVG--------------------------------W 627
                                       .:|.|                                |
Human   518 EISDRLPAASWEGQESCWNKQTSKSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVW 582

  Fly   628 RPTFKYY----NMWLSLLGAILCVAVMFLISWATALITFAAVLALYLIVAYRKPDVNWGSTTQAQ 688
            |.:..:|    |.|:|||||:..:.:||:|.|...|:.......:|..:....|.::.||.:...
Human   583 RRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFS 647

  Fly   689 TYK----NALMSVQQLNNVEEHV 707
            .::    ..|.|.:.|.:.:|.:
Human   648 FFRWMRSLLLPSCRSLRSPQEQI 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_2	155..1207	CDD:459263	168/673 (25%)
SLC12A8	NP_078904.4	AA_permease_2	35..>407	CDD:459263	142/408 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	471..503		0/31 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	530..550		1/19 (5%)