DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ncc69 and CCC1

DIOPT Version :9

Sequence 1:	NP_001261758.1	Gene:	Ncc69 / 39410	FlyBaseID:	FBgn0036279	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_174333.2	Gene:	CCC1 / 839924	AraportID:	AT1G30450	Length:	975	Species:	Arabidopsis thaliana

Alignment Length:	1095	Identity:	285/1095 - (26%)
Similarity:	460/1095 - (42%)	Gaps:	276/1095 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 DELHN----ATLVGKNTHSLTRNQDPES-GILNG-----VLKFGWIKGVLVRCLLNIWGVMLFLR 234
            |.|.|    .::.|:...:.:..:|.|. .|..|     .||.|.:.||.|.||.||.|::.::|
plant    90 DSLVNILGLKSMTGEQIQAPSSPRDGEDISITQGHPKPPALKMGTMMGVFVPCLQNILGIIYYIR 154

  Fly   235 LSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMISRSLGPEFGGSIGLIF 299
            .:|:||.||:.:|.||:......|.:|.:|:|||:|||.:||||.||:|.|:||||.|.||||.|
plant   155 FTWIVGMAGIGQGLVLVFLCGLCTFLTTISLSAIATNGAMKGGGPYYLIGRALGPEVGISIGLCF 219

  Fly   300 SLANAVACAMYVVGFCESML----------AMMTTFGWEIIDGGVQ-----DVRIIGCITILLLL 349
            .|.||||.|:||:|..|:.|          ..:|......:...:|     |:::.|.:..:||.
plant   220 FLGNAVAGALYVLGAVETFLKAFPAAGIFRETITKVNGTAVSESIQSPNSHDLQVYGIVVTILLC 284

  Fly   350 IIVVVGMEWEAKAQIGLLIILLVAIGDFVIGSFIGPKSDAEMAKGFLGYNATLFKNNLFADYR-- 412
            .||..|::...:.....|:.:|::|....||.|:....|.:  .|..|.....||:|..:.|:
plant   285 FIVFGGVKMINRVAPAFLVPVLLSIFCIFIGIFLAKTDDPD--NGITGLRLKSFKDNWGSAYQMT 347

  Fly   413 -----PE-KGGIQHDFFSVFAIFFPAATGILAGANISGDLKDPQKSIPKGTILAIVITTGTYLIM 471
                 |: .||....|..:..:||||.|||:||:|.|..|||.|||||.||:.|.:.||..|||.
plant   348 NDAGIPDPTGGTYWSFNELVGLFFPAVTGIMAGSNRSASLKDTQKSIPVGTLAATLTTTSLYLIS 412

  Fly   472 VLQCGATVARDATGNLSD-VVNGTFAFLDCQPGECNYGLQNSFQVIELVSAFGPLIYAGCYAATL 535
            ||..||...||..  |:| ::..|.|:                       .|..:::.|...:||
plant   413 VLFFGAVATRDKL--LTDRLLTATIAW-----------------------PFPAIVHVGIILSTL 452

  Fly   536 SSALASLVSAPKVFQALCKDELYPKIVWFAKGYGKNNEPVRGYVLTFIIACAFILIGELNLIAPL 600
            .:||.||..||::..|:..|::.|.:.:|.  ....:||....:.|..|....::||.|:||.|.
plant   453 GAALQSLTGAPRLLAAIANDDILPILNYFK--VADTSEPHIATLFTAFICIGCVVIGNLDLITPT 515

  Fly   601 ISNFFLAAYMLINFSTFHASLAKPVGWRPTFKYYNMWLSLLGAILCVAVMFLISWATALITFAAV 665
            ::.|:|..|..:|.|.|...|.....|||.:||::..||.:||.||:.:||||||:..::..|..
plant   516 VTMFYLLCYSGVNLSCFLLDLLDAPSWRPRWKYHHWSLSFVGASLCIVIMFLISWSFTVVAIALA 580

  Fly   666 LALYLIVAYRKPDVNWGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQILVL----SGLPNT--- 723
            ..:|..|..:....:||...::..::.||.|::.|...:.|.||:.|..||.    ..||..
plant   581 SLIYKYVGLKGKAGDWGDGFKSAYFQLALRSLRSLGANQVHPKNWYPIPLVFCRPWGQLPENVPC 645

  Fly   724 RPVLVDLAYMLTK---NLSLLV---------CGHVLKGSSSQKYRTYLQERAGNWFRKHRVKGFY 776
            .|.|.|.|..:.|   .:|:.|         |....|.:..| ..||::.:        |.:|..
plant   646 HPKLADFANCMKKKGRGMSIFVSILDGDYYECAEEAKEACKQ-LATYIEYK--------RCEGVA 701

  Fly   777 ALVDGEDFESGTRALMQATGIGKLKPNIILMGYKTDWQTCDHKELDQYF-NVMHKALDMYLSVAI 840
            .:|...:...|.|.::|..|:|.|||||::|.|...|:..:..|:...| .:::..:....:|.|
plant   702 EIVVAPNMTEGFRGIIQTMGLGNLKPNIVVMRYPEIWRRENLTEIPSTFVGIINDCITANKAVVI 766

  Fly   841 LRVPQGLDCSQVLGSQDGWKTVSDVPRTLQPNESSGDLQAVDSSVRNGLSGSIDSLSRNVSQEDR 905
            ::   ||         |.|           |||
plant   767 IK---GL---------DEW-----------PNE-------------------------------- 776

  Fly   906 NRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGNQSKDVSGMPDPLDAKSANL 970

plant   777 ----------------------------------------------------------------- 776

  Fly   971 VSNSLRKSKLKHDDPASLYKGPGGAELPKEVLADLTQFTRKRSHAVIDVWWLYDDGGLTLLLPYI 1035
                                                   .:|.:..||::|:..||||.|||..:
plant   777 ---------------------------------------YQRQYGTIDLYWIVRDGGLMLLLSQL 802

  Fly  1036 ISTRRTWQSCKLRVYALANKNSELEFEQRSMASLLSKFRIDYSDLTLIP----DITKK--PQETS 1094
            :.|:.:::|||::::.:|.::|:.|..:..:...|...|: ::::.::.    ||..:  .||.|
plant   803 LLTKESFESCKIQLFCIAEEDSDAEALKADVKKFLYDLRM-HAEVIVVTMKSWDIRSEGNSQEDS 866

  Fly  1095 TQFFN---ELIKDFV-VTEKDGEN---GTSSRATLNEDDALITDDDLLAVQDKTNRYLRLREYLR 1152
            .:.|:   ..|.|:: ..::.|.|   .......:||..          |:......|:|...:.
plant   867 LEAFDAAQRRISDYLGEIKRQGSNPLLANGKPMVVNEQQ----------VEKFLYTMLKLNSTIL 921

  Fly  1153 EQSTKSDLVVMTLPMPRKNIVSAPLYMAWLESLSRDMPPFLFVRGNQTSVLTFYS 1207
            ..|..:.:|:::||.|..| ..|..||.:::.|..::|..|.|||....|:|.::
plant   922 SYSRMAAVVLVSLPPPPLN-HPAYFYMEYMDLLVENVPRMLIVRGYHRDVVTLFT 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588	1/2 (50%)
		2a30	155..1207	CDD:273347	285/1093 (26%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	50/157 (32%)
		SLC12	724..1207	CDD:281515	91/508 (18%)
CCC1	NP_174333.2	2a30	56..975	CDD:273347	285/1093 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	278	1.000	Domainoid score	I408
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020