Protein Alignment Ncc69 and Slc12a9

DIOPT Version :10

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: NP_113583.2
• Gene: Slc12a9 / 83704
• MGIID: 1933532
• Length: 914
• Species: Mus musculus
• Alignment Length: 1093
• Identity: 280/1093 - (25%)
• Similarity: 454/1093 - (41%)
• Gaps: 266/1093 - (24%)

  Fly   174 AYRPTLDELHNATLVGKNTHSLTRNQDPESGILNGVLKFGWIKGVLVRCLLNIWGVMLFLRLSWV 238
            |||          |:|:...:...|....||:.:. .|.....||:|..:|:::.:::|||:.:|
Mouse    10 AYR----------LLGEEGAAFPPNGAGVSGVPSS-RKLSTFLGVVVPTVLSMFSIVVFLRIGFV 63

  Fly   239 VGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMISRSLGPEFGGSIGLIFSLAN 303
            ||.||:::...::|....:..:|.||:.||:|||.::|||.|:||||:||||.||||||:|.|||
Mouse    64 VGHAGLLQALAMLLVAYIILALTVLSVCAIATNGAVRGGGAYFMISRTLGPEVGGSIGLMFYLAN 128

  Fly   304 AVACAMYVVGFCESML--------------AMMTTFGWEIIDGGVQDVRIIGCITILLLLI--IV 352
            ...||:.::|..||:|              .:...:||.::.|           ::||.|:  :.
Mouse   129 VCGCAVSLLGLVESILDVFGADATGSSGIQVLPQGYGWNLLYG-----------SLLLGLVGGVC 182

  Fly   353 VVGMEWEAKAQIGLLIILLVAIGDF--VIGSF--IGPK------------SDAEMAKG-FLGYNA 400
            .:|....|:|  ..|..|||: |..  |:.||  :||:            |......| |.|:|.
Mouse   183 TLGAGLYARA--SFLTFLLVS-GSLASVLVSFVAVGPRNIPLAPRPGTNASSVPHRHGHFTGFNG 244

  Fly   401 TLFKNNLFADYRPE-KGGIQHDFFSVFAIFFPAATGILAGANISGDLKDPQKSIPKGTILAIVIT 464
            :..::||.|.|..: ..|....|.||||:.|...|||:||||:||:||||.::||.|||:|:..|
Mouse   245 STLRDNLGAGYAEDYTTGAMMTFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIIAVAYT 309

  Fly   465 TGTYLIMVLQCGATVARDATGNLSDVVNGTFAFLDCQPGECNYGLQNSFQVIELVSAFGPLIYAG 529
            ...|:::......|..|..                         ||..:.....:|.:.||:..|
Mouse   310 FFIYILLFFLSSFTCDRAL-------------------------LQEDYGFFRDISLWPPLVLIG 349

  Fly   530 CYAATLSSALASLVSAPKVFQALCKDELYPKIVWFAKGYGKNNEPVRGYVLTFIIACAFILIGEL 594
            .||..||::::||:.|.::..||.:|:|:..|:..||.......|....:.::.:....:|.|:|
Mouse   350 IYATALSASMSSLIGASRILHALAQDDLFGVILAPAKVVSGGGNPWGAVLYSWGLVQLVLLAGKL 414

  Fly   595 NLIAPLISNFFLAAYMLINFSTFHASLAKPVGWRPTFKYYNMWLSLLGAILCVAVMFLISWATAL 659
            |.:|.:::.|:|.||..::.|......|....:||||..::....|||...|:.:|||||...|.
Mouse   415 NTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAG 479

  Fly   660 ITFAAVLALYLIVAYRKPDVNWGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQILVLSGLPNTR 724
            .:...:..|..::..|....:||..:||..:......:.:|:..:||||.:|||:|:|.|.|...
Mouse   480 GSLLLMGLLSALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKEHVKFWRPQLLLLVGNPRGA 544

  Fly   725 PVLVDLAYMLTKNLSLLVCGHVLKGSSSQKYRTYLQERAGNWFR---KHRVKGFYALVDGEDFES 786
            ..|:.||..|.|. .|.|.|||..|.........:|.:.|.|..   ..:||.|..|........
Mouse   545 LPLLRLANQLKKG-GLYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDLAQVKAFVDLTLSPSVRQ 608

  Fly   787 GTRALMQATGIGKLKPNIILMGYKTDWQTCDHKELDQYFNVMHKALDMYLSVAILRVPQGLDCSQ 851
            |.:.|::.:|:|.:|||.:::|:..|....||...|..|:
Mouse   609 GAQHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDPAFS------------------------- 648

  Fly   852 VLGSQDGWKTVSDVPRTLQPNESSGDLQAVDSSVRNGLSGSIDSLSRNVSQEDRNRNQLVHSEQN 916
                              :|.|.:          |.|.|.::.:|
Mouse   649 ------------------EPAEGT----------REGGSPALSTL-------------------- 665

  Fly   917 SLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGNQSKDVSGMPDPLDAKSANLVSNSLRKSKLK 981
                        ....|: ||:..:.|...::|                    .|:::|:.:|
Mouse   666 ------------FPPPRA-PGSPRALSPQDYVA--------------------TVADALKMNK-- 695

  Fly   982 HDDPASLYKGPGGAELPKEVLADLTQFTRKRSHAVIDVWWL-----------YDDGGLTLL-LPY 1034
               ...|.:..|.  ||.|.|:..:..:.:..|  :|||.|           .|..||.|| :..
Mouse   696 ---NVVLARACGA--LPPERLSRGSSSSAQLHH--VDVWPLNLLRPRGGPGYVDVCGLFLLQMAT 753

  Fly  1035 IISTRRTWQSCKLRVYALANKNSELEFEQRSMASLLSKFRIDYSDLTLIPDI-------TKKPQE 1092
            |:|....|.|.:||::............:..:.:|||:.||...    :.::       |.:|:|
Mouse   754 ILSMVPAWHSARLRIFLCLGPREAPGAAEGRLRALLSQLRIRAE----VQEVVWGEGAETGEPEE 814

  Fly  1093 TSTQFFNELIKDFVVTEKDGENGTSSRATLNEDDALITDDDLLAVQDKTNRYLRLREYL------ 1151
            ....|.|            |..|               |::..|:....|..:|.::..
Mouse   815 EEGDFVN------------GGRG---------------DEEAEALACSANALVRAQQGRGTVGGP 852

  Fly  1152 -------REQSTKSDLVVMTLPMPRKNIVSAPLYMAWLESLSRDMPPFLFVRG 1197
                   .|:...:.|..:.||.|..:....|.|:|.||:||||:.|.|.:.|
Mouse   853 GGPEGRDGEEGPTTALTFLYLPRPPADPARYPRYLALLETLSRDLGPTLLIHG 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_2	155..1207	CDD:459263	280/1093 (26%)
Slc12a9	NP_113583.2	AA_permease_2	36..905	CDD:459263	271/1054 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..678		10/118 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	844..864		1/19 (5%)