Protein Alignment Ncc69 and Slc12a2

DIOPT Version :9

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: NP_113986.2
• Gene: Slc12a2 / 83629
• RGDID: 620809
• Length: 1203
• Species: Rattus norvegicus
• Alignment Length: 1258
• Identity: 551/1258 - (43%)
• Similarity: 755/1258 - (60%)
• Gaps: 169/1258 - (13%)

  Fly     3 DTISFELGSAADRPPNRFQVNPVNGNSRKSQGADGPGSGSGAGAGAGAGAGEDGPHEVYRRLTNA 67
            |.:...||....:  :||||:||:.|:       |..:.:.|.|.|.|.||..|      :.|.|
  Rat    62 DGLGKPLGPTPSQ--SRFQVDPVSENA-------GRAAAAAAAAAAAAAAGAAG------KETPA 111

  Fly    68 EGELLEDDTFDATQMLNQRQPRQQRQSIKSSFRDKDKPSRFKD-LQTTTRFQVDPQNEESDESND 131
            .|:.       .|:....:...:.:...:.:|.|....|...| |........|..|.......|
  Rat   112 AGKA-------GTESGVAKGSEEAKGRFRVNFVDPAASSSADDSLSDAAGVGGDGPNVSFQNGGD 169

  Fly   132 S---------------QEERELLDNEYDTKYGKSFRHFTREALPRLDNYRNMMSI--QAAYRPTL 179
            :               ..::...|...:|.|.::|.|.|.:|:||:|:||:..:.  :...||:|
  Rat   170 TVLSEGSSLHSGGGSGHHQQYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLRPSL 234

  Fly   180 DELHNATLVGKNTHSLTRNQDP-ESGILN-------------------GVLKFGWIKGVLVRCLL 224
            .|||:..           .::| |.|..|                   ||:||||||||||||:|
  Rat   235 AELHDEL-----------EKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCML 288

  Fly   225 NIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMISRSLGP 289
            ||||||||:||||:|||||:....::|...|.|||||.||.|||:|||.::|||.||:|||||||
  Rat   289 NIWGVMLFIRLSWIVGQAGIGLSVLVIAMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGP 353

  Fly   290 EFGGSIGLIFSLANAVACAMYVVGFCESMLAMMTTFGWEIIDGGVQDVRIIGCITILLLLIIVVV 354
            ||||:|||||:.|||||.|||||||.|:::.::......:|| .:.|:||||.||:::||.|.|.
  Rat   354 EFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMID-EINDIRIIGAITVVVLLGISVA 417

  Fly   355 GMEWEAKAQIGLLIILLVAIGDFVIGSFIGPKSDAEMAKGFLGYNATLFKNNLFADYRPEKGGIQ 419
            ||||||||||.||:|||:||.|||||:||  ..|::..|||.||.:.:|..|...|:|.|:
  Rat   418 GMEWEAKAQIVLLVILLLAIADFVIGTFI--SLDSKKPKGFFGYKSEIFSENFGPDFREEE---- 476

  Fly   420 HDFFSVFAIFFPAATGILAGANISGDLKDPQKSIPKGTILAIVITTGTYLIMVLQCGATVARDAT 484
             .|||||||||||||||||||||||||.|||.:|||||:|||:|||..|:.:.:..|:.|.||||
  Rat   477 -TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTVVYIGIAVSVGSCVVRDAT 540

  Fly   485 GNLSDVV-----NGT-------FAFLDCQPGECNYGLQNSFQVIELVSAFGPLIYAGCYAATLSS 537
            ||::|.:     |.|       |.|..|:...|:|||.|:|||:.:||.|.|||.||.::|||||
  Rat   541 GNVNDTITTELTNCTSAACKLNFDFSYCESNTCSYGLMNNFQVMSMVSGFAPLISAGIFSATLSS 605

  Fly   538 ALASLVSAPKVFQALCKDELYPKIVWFAKGYGKNNEPVRGYVLTFIIACAFILIGELNLIAPLIS 602
            ||||||||||:|||||||.:||....|||||||||||:|||:|||:||..||||.|||:|||:||
  Rat   606 ALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIIS 670

  Fly   603 NFFLAAYMLINFSTFHASLAKPVGWRPTFKYYNMWLSLLGAILCVAVMFLISWATALITFAAVLA 667
            |||||:|.|||||.|||||||..||||.|||||||:||.|||||..|||:|:|..||:|:..||.
  Rat   671 NFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLTGAILCCIVMFVINWWAALLTYVIVLG 735

  Fly   668 LYLIVAYRKPDVNWGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQILVLSGLPNTRPVLVDLAY 732
            ||:.|.|:||||||||:|||.||.:||....:|:.||:||||:|||.||::|.||:||.|:.|.:
  Rat   736 LYIYVTYKKPDVNWGSSTQALTYLSALQHSIRLSGVEDHVKNFRPQCLVMTGSPNSRPALLHLVH 800

  Fly   733 MLTKNLSLLVCGHVLKGSSSQ--KYRTYLQERAGNWFRKHRVKGFYALVDGEDFESGTRALMQAT 795
            ..|||:.|::||||..|...|  |..:..|.:...|..|:::|.|||.|..:|...|.:.||||.
  Rat   801 DFTKNVGLMICGHVHMGPRRQAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAA 865

  Fly   796 GIGKLKPNIILMGYKTDWQTCDHKELDQYFNVMHKALDMYLSVAILRVPQGLDCSQVLGSQDGWK 860
            |:|::|||.:::|:|.||...|.:::|.|.|:.|.|.|:...|.::|:.:|||.|.:.|.::...
  Rat   866 GLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLS 930

  Fly   861 TVSDVPRTLQPNESSGDLQAVDSSVRNGLSGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRF 925
            :....|.|      ...:..||.|.::.......|..:.::|:|...:
  Rat   931 SQEKSPGT------KDVVVNVDYSKKSDQDAFKASGEKPITQKDEEED----------------- 972

  Fly   926 KQGLRRMRSWPGAASSTSDLSFIAGNQSKDVSGMPDPLDAKSANLVSNSLRKSKLKHDDPASLYK 990
                        ..:||..|      ..|:..|...||:.....|:..|
  Rat   973 ------------GKTSTQPL------LKKESKGPVAPLNVADQKLLEAS---------------- 1003

  Fly   991 GPGGAELPKEVLADLTQFTRKRSHAVIDVWWLYDDGGLTLLLPYIISTRRTWQSCKLRVYALANK 1055
                           |||.:|:....||||||:||||||||:||:::|::.|:.||:||: :..|
  Rat  1004 ---------------TQFQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVF-IGGK 1052

  Fly  1056 NSELEFEQRSMASLLSKFRIDYSDLTLIPDITKKPQETSTQFFNELIKDFVVTEKDGENGTSSRA 1120
            .:.::.::|:||:||||||||:||:.::.||..||::.:...|:::|:.:.:.|.|.|...:.:
  Rat  1053 INRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENIVAFDDMIEPYRLHEDDKEQDIADK- 1116

  Fly  1121 TLNEDDA-LITDDDLLAVQDKTNRYLRLREYLREQSTKSDLVVMTLPMPRKNIVSAPLYMAWLES 1184
             :.||:. .|||::|...:.||.|.:||.|.|:|.|:.::::||:||:.||..||:.|||||||:
  Rat  1117 -MKEDEPWRITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEA 1180

  Fly  1185 LSRDMPPFLFVRGNQTSVLTFYS 1207
            ||:|:||.|.||||..|||||||
  Rat  1181 LSKDLPPILLVRGNHQSVLTFYS 1203

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588	15/40 (38%)
		2a30	155..1207	CDD:273347	514/1088 (47%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	115/157 (73%)
		SLC12	724..1207	CDD:281515	163/485 (34%)
Slc12a2	NP_113986.2	2a30	207..1203	CDD:273347	514/1089 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352206
Domainoid	1	1.000	629	1.000	Domainoid score	I166
eggNOG	1	0.900	-	-		E2759_KOG2083
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20283
Inparanoid	1	1.050	993	1.000	Inparanoid score	I287
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D135130at33208
OrthoFinder	1	1.000	-	-		FOG0001536
OrthoInspector	1	1.000	-	-		mtm8955
orthoMCL	1	0.900	-	-		OOG6_101360
Panther	1	1.100	-	-	LDO	PTHR11827
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X709
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770