Protein Alignment Ncc69 and slc12a5b

DIOPT Version :10

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: XP_009302423.1
• Gene: slc12a5b / 797331
• ZFINID: ZDB-GENE-080707-1
• Length: 1126
• Species: Danio rerio
• Alignment Length: 1379
• Identity: 326/1379 - (23%)
• Similarity: 515/1379 - (37%)
• Gaps: 487/1379 - (35%)

  Fly    53 GEDGPHEVYRRLTNAEGELLEDDTFDATQMLNQRQPRQQRQSIKSSFRDKDKPSRFKDLQTTTRF 117
            |:.||        |::|        |||.       ::....|.||..|.:|..
Zfish    11 GDGGP--------NSQG--------DATS-------KESSPFINSSTSDVEKSQ----------- 41

  Fly   118 QVDPQNEESDESNDSQEERELLDNEYDTKYGKSFRHFTREALPRLDNYRNMMSIQAAYRPTLDEL 182
            |.|.:|            ..|.:.|.||.      ......|..|.||.|:..
Zfish    42 QYDGKN------------MALFEEEMDTS------PMVSSLLSSLANYSNLTQ------------ 76

  Fly   183 HNATLVGKNTHSLTRNQDPESGILNGVLKFGWIKGVLVRCLLNIWGVMLFLRLSWVVGQAGVIEG 247
                  |...|....|.:..........:.|.|.||.:.||.||.||:||||::|:||..||:..
Zfish    77 ------GSKEHEEAENNEEARKKAAQAPRMGTIMGVYLPCLQNILGVILFLRMTWLVGVGGVLGT 135

  Fly   248 FVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMISRSLGPEFGGSIGLIFSLANAVACAMYVV 312
            |.::....:.|.:||:|||||:||||:..||:||||||||||||||::|:.|.|....|.|||::
Zfish   136 FTIVFMCCSTTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGICFFLGTTFAGAMYIL 200

  Fly   313 GFCESMLAMM----TTFGWEIIDGG------VQDVRIIGCITILLLLIIVVVGMEWEAKAQIGLL 367
            |..|.:|..:    ..|..|.::|.      :.::|:.|.|.:..:.|:|.||:::..|..:..|
Zfish   201 GCIEILLIYIVPSAAIFKMEGLEGSEAEAALLNNMRVYGTIVLTFMAIVVFVGVKYVNKLALVFL 265

  Fly   368 IILLVAI--------------GDF---VIGS---------------------------------- 381
            ..::::|              .||   |:|:
Zfish   266 ACVILSILAIYAGVIKTSFDPPDFPVCVLGNRTLVSKAYDICAKTIERGNATITTKLWRSFCDSE 330

  Fly   382 FIGPKSD-------AEMAKGFLGYNATLFKNNLFADYRP-----EKGGIQ--------------- 419
            |:....|       ....:|..|..:.:...|||:.|..     ||.|:|
Zfish   331 FLNATCDEYFVNNNISQIQGIPGVTSGILAENLFSGYMEKNSVLEKRGLQAVQDPELPVTNSNRY 395

  Fly   420 -----HDFFSVF-AIFFPAATGILAGANISGDLKDPQKSIPKGTILAIVITTGTYLIMVLQCGA- 477
                 ..||::. .|:||:.|||:||:|.||||:|.|||||.||||||..|:..|:..|:..||
Zfish   396 VLADITSFFTLLVGIYFPSVTGIMAGSNRSGDLQDAQKSIPVGTILAITTTSIIYMSSVILFGAC 460

  Fly   478 ---TVARD-----ATGNLSDVVNGTFAFLDCQPGECNYGLQNSFQVIELVSAFGPLIYAGCYAAT 534
               .|.||     .:|||   |.||.|:    |...                   :|..|.:.:|
Zfish   461 VDGVVLRDKFGEGVSGNL---VIGTLAW----PSPW-------------------VIVFGSFFST 499

  Fly   535 LSSALASLVSAPKVFQALCKDELYPKIVWFAKGYGK-NNEPVRGYVLTFIIACAFILIGELNLIA 598
            ..:.|.||..||::.||:.:|.:.|.:..|  |:|| |.||....:||..|..:.|||..|:.:|
Zfish   500 CGAGLQSLTGAPRLLQAIARDGIIPFLRVF--GHGKANGEPTWALLLTACICESGILIASLDAVA 562

  Fly   599 PLISNFFLAAYMLINFSTFHASLAKPVGWRPTFKYYNMWLSLLGAILCVAVMFLISWATALITFA 663
            |::|.|||..||.:|.:....:|.:...|||.||:|:..|||||..||:.:|||.||..|::...
Zfish   563 PILSMFFLMCYMFVNLACALQTLLRTPNWRPRFKFYHWALSLLGMSLCLTLMFLCSWYYAIVAMV 627

  Fly   664 AVLALYLIVAYRKPDVNWGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQILVLSGLPN----TR 724
            ....:|..:.:...:..||...:..:...|..::.:|.....|.||:|||||||:.|..    .:
Zfish   628 IAGCIYKYIEFCGAEKEWGDGIRGISLSAARFALMRLEEGPPHTKNWRPQILVLTTLDGEQNVEQ 692

  Fly   725 PVLVDLAYMLTKNLSLLVCGHVLKGSSSQKYRTYLQ-----ERAGNWFRK----HRVKGFYALVD 780
            |.|:.|...|.....|.:.|..::|       |||.     ::|....||    .:||||..:|.
Zfish   693 PRLLSLTSQLKAGKGLTIVGACIEG-------TYLNNQPKTQKADQSLRKLMEVEKVKGFSQVVI 750

  Fly   781 GEDFESGTRALMQATGIGKLKPNIILMGYKTDW-QTCDHKELDQYFNVMHKALDMYLSVAILRVP 844
            ..:....|..|:||.|:|.|:.|.:|:.:..:| |..:|.....:..|:.:....::::.
Zfish   751 SSNLRDATSHLIQAGGLGGLRHNTVLVSFPKNWKQAEEHHRCRNFIEVVRETTAGHMALL----- 810

  Fly   845 QGLDCSQVLGSQDGWKTVSDVPRTLQPNESSGDLQAVDSSVRNGLSGSIDSLSRNVSQEDRNRNQ 909
                                ||:.:....|:|:
Zfish   811 --------------------VPKNISAYPSNGE-------------------------------- 823

  Fly   910 LVHSEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGNQSKDVSGMPDPLDAKSANLVSNS 974
                          ||.:|
Zfish   824 --------------RFTEG---------------------------------------------- 828

  Fly   975 LRKSKLKHDDPASLYKGPGGAELPKEVLADLTQFTRKRSHAVIDVWWLYDDGGLTLLLPYIISTR 1039
                                                   |  |||||:..|||:.:|||:::...
Zfish   829 ---------------------------------------H--IDVWWIVHDGGMLMLLPFLLRQH 852

  Fly  1040 RTWQSCKLRVYALANKNSELEFEQRSMASLLSKFRIDYS----------------DLTLIPD--- 1085
            :.|:.||:|::.:|..:......::.:.:.|...|:|.:                :.||:.:
Zfish   853 KVWRKCKMRIFTVAQMDDNSIQMKKDLMTFLYHLRLDAAVEVVEMLDNDISAYTYEKTLMMEQRS 917

  Fly  1086 -------ITKKPQETSTQFFNELIKDFV-------------VTEK-------------------- 1110
                   :||..:|...|...::.:..:             :.|:
Zfish   918 QILKEMHLTKNEREREIQSITDVSRGSIRRKNPSNLHPQRSIAEESVAGSGEEKPEEESVRVSHP 982

  Fly  1111 ------DGENGT-----------SSRATLNEDDAL---ITDDDLLA----------VQDKTN--- 1142
                  .|:|.|           .:.||::..:.:   .|||...|          ::|..|
Zfish   983 RQVQLIQGKNATPTPTSPTSPTAPTPATMSPGEEIQMTWTDDTEKANNPAVANPENIKDMFNMKP 1047

  Fly  1143 --------------RYLRLREYLREQSTKSDLVVMTLPMPRKNIVSAPLYMAWLESLSRDMPPFL 1193
                          ...:|.|.:.::|.::.||::.:|.|.:|......||.:||.|:..:...|
Zfish  1048 EWENLNQSNVRRMHHAQKLNEVIVKKSQEAKLVLLNMPGPPRNRTGEENYMEFLEVLTEGLNRVL 1112

  Fly  1194 FVRGNQTSVLTFYS 1207
            .|||....|:|.||
Zfish  1113 LVRGGGREVITIYS 1126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_2	155..1207	CDD:459263	304/1275 (24%)
slc12a5b	XP_009302423.1	AA_permease_2	24..1126	CDD:459263	316/1341 (24%)