Protein Alignment Ncc69 and slc12a6

DIOPT Version :10

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: XP_012820954.1
• Gene: slc12a6 / 780031
• XenbaseID: XB-GENE-960699
• Length: 1133
• Species: Xenopus tropicalis
• Alignment Length: 1375
• Identity: 346/1375 - (25%)
• Similarity: 534/1375 - (38%)
• Gaps: 435/1375 - (31%)

  Fly     8 ELGSAADRPPNRFQVNPVNGNSRKSQGADGPGSGSGAGAGAGAGAGEDGPHEVYRRLTNAEGELL 72
            |:|:.:|..|:....:.|..:||:|                   ..:....|.|
 Frog    19 EMGAISDTSPDLSSSSRVRFSSRES-------------------VRDASRSEAY----------- 53

  Fly    73 EDDTFDATQMLNQRQPRQQRQSIKSSFRDK----DKPSRFKDLQTTTRFQVDPQNEESDESNDSQ 133
             .||..||..::|...|..........|.:    ::.|:..|:. ..:..|..||...||.:...
 Frog    54 -SDTSLATTGVDQASERTSNPMDSGEDRSQTSVTEENSKLLDID-RRKSSVLYQNHTDDEGDSYD 116

  Fly   134 EERELLDNEYDTKYGKSFRHFTREALPRLDNYRNMMSIQAAYRPTLDELHNATLVGKNTHSLTRN 198
            ....|.:.|.||      |......|.||.||.|:        |...:.|.....||...:.|.
 Frog   117 RNLALFEEEMDT------RPKVSSLLNRLANYTNL--------PQGAKEHEEESEGKKKAAKTP- 166

  Fly   199 QDPESGILNGVLKFGWIKGVLVRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITAL 263
                        :.|.|.||.:.||.||:||:|||||.||||.|||:..|.::......|.:||:
 Frog   167 ------------RMGTIMGVYLPCLQNIFGVILFLRLPWVVGTAGVLHAFCIVFACCCCTMLTAI 219

  Fly   264 SMSAISTNGVIKGGGTYYMISRSLGPEFGGSIGLIFSLANAVACAMYVVGFCESMLAMMTTFGWE 328
            |||||:||||:..||.|:||||:|||||||::||.|.|....|.|||::|..|..|..::.....
 Frog   220 SMSAIATNGVVPAGGAYFMISRALGPEFGGAVGLCFYLGTTFATAMYILGAIEIFLVYISPQAVI 284

  Fly   329 IIDGGV--------QDVRIIGCITILLLLIIVVVGMEWEAK-AQIGLLIILLVAIG--------- 375
            ....||        .::|:.|...::::.|||.||:.:..| |.:.|..:::..:.
 Frog   285 FHGEGVAEESAAMLNNMRVYGTGFLIIMSIIVFVGVRYVNKLASVFLTCVIMSILAIYAGALKSA 349

  Fly   376 ----DF---VIGS-----------------------------FIGPK-------------SDAEM 391
                ||   ::|:                             |..|.             ::..:
 Frog   350 FSPPDFPICLLGNRTLSKHHFTECAKIVESDNMTIVTDLWNLFCHPSDQLNGTCDEYFAHNNVTL 414

  Fly   392 AKGFLGYNATLFKNNLFADYRPEKG------------------------GIQHDFFSVFAIFFPA 432
            .:|..|..:.:...||:::|. :||                        .|...|..:..||||:
 Frog   415 VQGIPGLKSGIISENLWSNYL-QKGDIIEKASLPSTEYLAVQSQEYVLADITTSFTLLVGIFFPS 478

  Fly   433 ATGILAGANISGDLKDPQKSIPKGTILAIVITTGTYLIMVLQCGAT----VARDATGNLSDVVNG 493
            .|||:||:|.||||||.|||||.||||||:.|:..||..|:..||:    |.||..|   |.|.|
 Frog   479 VTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSLVYLSNVILFGASIDGVVLRDKFG---DAVKG 540

  Fly   494 TFAFLDCQPGECNYGLQNSFQVIELVSAFGP-LIYAGCYAATLSSALASLVSAPKVFQALCKDEL 557
            |.                   |:..:|...| :|..|.:.:|..:.|.||..||::.||:.||.:
 Frog   541 TL-------------------VVGALSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDGI 586

  Fly   558 YPKIVWFAKGYGKNN-EPVRGYVLTFIIACAFILIGELNLIAPLISNFFLAAYMLINFSTFHASL 621
            .|.:..|  |:||:| ||....:||.:||...|||..|:|:||::|.|||..|:.:|.:....:|
 Frog   587 IPFLRVF--GHGKSNGEPTWALLLTAVIAELGILIASLDLVAPILSMFFLMCYLFVNLACGLQTL 649

  Fly   622 AKPVGWRPTFKYYNMWLSLLGAILCVAVMFLISWATALITFAAVLALYLIVAYRKPDVNWGSTTQ 686
            .....|||.|.||:..||.||..||:|:||:.||..|||:......:|..:.|:..:..||...:
 Frog   650 LHSPNWRPRFHYYHWTLSFLGMALCLALMFISSWYYALISMVIAGMIYKYIEYQGAEKEWGDGIR 714

  Fly   687 AQTYKNALMSVQQLNNVEEHVKNYRPQILVL----SGLPNTRPVLVDLAYMLTKNLSLLVCGHVL 747
            ..:...|..::.:|.....|.||:|||:|||    |.|..::|.|:..|..|.....|.:.|.||
 Frog   715 GLSLSAARFALLRLEEGPPHTKNWRPQLLVLVKLDSDLHVSQPRLLSFASQLKAGKGLTIVGSVL 779

  Fly   748 KGSSSQKYRTYLQERAGNWFRKH-----RVKGFYALVDGEDFESGTRALMQATGIGKLKPNIILM 807
            .|...:   .:.:.:|.....||     :||||..:|..:..:.|...|:|:.|:|.::.|.::|
 Frog   780 LGDYLE---NHAEAQAAEQALKHLMEQEKVKGFCQVVVAQKLKEGLSHLIQSCGLGGMRHNTVIM 841

  Fly   808 GYKTDWQTCDHKELDQYFNVMHKALDMYLSVAILRVPQGLDCSQVLGSQDGWKTVSDVPRTLQPN 872
            .:.:.|:..|...                                     .||:.....|
 Frog   842 SWPSSWRQSDDSR-------------------------------------AWKSFITTIR----- 864

  Fly   873 ESSGDLQAVDSSVRNGLSGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPG 937
                    |.::.|..|     .:::|||                                .:||
 Frog   865 --------VTTAARQAL-----LVAKNVS--------------------------------LFPG 884

  Fly   938 AASSTSDLSFIAGNQSKDVSGMPDPLDAKSANLVSNSLRKSKLKHDDPASLYKGPGGAELPKEVL 1002
            :                                                            :|:|
 Frog   885 S------------------------------------------------------------REIL 889

  Fly  1003 ADLTQFTRKRSHAVIDVWWLYDDGGLTLLLPYIISTRRTWQSCKLRVYALANKNSELEFEQRSMA 1067
            |:        .|  |||||:..|||:.:|||:::...:.|:.||:|::.:|.........::.:|
 Frog   890 AE--------GH--IDVWWIVHDGGMLMLLPFLLKQHKVWRKCKMRIFTVAQMEDNSIQMKKDLA 944

  Fly  1068 SLLSKFRI------------DYS----DLTLIPD----------ITKKPQETSTQFFNELIKDFV 1106
            :.|...||            |.|    :.||:.:          ::|..:|...|    |:||
 Frog   945 TFLYHLRIAADVEVVEMHDSDISAYTYERTLMMEQRSQMLRQMRLSKTDREKEAQ----LVKD-- 1003

  Fly  1107 VTEKDGENGTSSRATLNEDDALITDDDLLAVQDKT------------------------------ 1141
                  .|......::..||    |:|..||.|:.
 Frog  1004 ------RNSMLRLTSVGSDD----DEDTEAVPDRVHMTWTKDKHHAVRVAQSKPMPSFQDLLNIR 1058

  Fly  1142 ---------NRYLRLREYLREQSTKSDLVVMTLPMPRKNIVSAPLYMAWLESLSRDMPPFLFVRG 1197
                     :..::|.|.:..:|..:.||::.:|.|.:|......||.:||.|:..:...|.|||
 Frog  1059 PDQSNVRRMHTAVKLNEVIVNKSHDAKLVLLNMPGPPRNPQGDENYMEFLEVLTEGLEHVLLVRG 1123

  Fly  1198 NQTSVLTFYS 1207
            ..|.|:|.||
 Frog  1124 GGTEVITIYS 1133

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_2	155..1207	CDD:459263	315/1222 (26%)
slc12a6	XP_012820954.1	2a30	104..1133	CDD:273347	324/1256 (26%)