DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ncc69 and zgc:153039

DIOPT Version :9

Sequence 1:	NP_001261758.1	Gene:	Ncc69 / 39410	FlyBaseID:	FBgn0036279	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	XP_021337145.1	Gene:	zgc:153039 / 767698	ZFINID:	ZDB-GENE-060929-736	Length:	942	Species:	Danio rerio

Alignment Length:	1100	Identity:	284/1100 - (25%)
Similarity:	467/1100 - (42%)	Gaps:	215/1100 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 EALPRLDNYRNMMSIQAAYRPTLDELHNATLVGKNTHSLTRNQDPESGILNGVL----KFGWIKG 217
            |..|.| :||...|   .:.|.....|..|....:....||::.|  |..|...    |.....|
Zfish     3 ERTPLL-HYRLSAS---GHEPGEPREHRQTTSAGHEEPDTRSRRP--GARNPAAAQPPKLNTFFG 61

  Fly   218 VLVRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYM 282
            |::..||:::.|::|||:.:||||.|:.:...::|....:.::|.||:.||||||.:..||.|||
Zfish    62 VVIPTLLSMFSVVVFLRIGFVVGQCGLYQTIAMLLVAYFIISMTVLSVCAISTNGALDAGGAYYM 126

  Fly   283 ISRSLGPEFGGSIGLIFSLANAVACAMYVVGFCESMLAMMTTFGWEIIDGGVQDVR--------- 338
            |||:||||||||||::|.|||....|:||:|..|   |::||||.. .||.:...|
Zfish   127 ISRALGPEFGGSIGIMFFLANVCGSALYVLGLVE---AVLTTFGLP-DDGSLSMSRSAVLPVGYW 187

  Fly   339 ---IIGCITILLLLIIVVVGMEWEAKAQIGLLIILLVAIGDFVIGSF---------------IGP 385
               :.|.:.:||.:::.:||....|||...:.||::|.:|...|..|               |||
Zfish   188 WSLLYGTVILLLCVLVCLVGAHIYAKATFLIFIIVMVVLGTIFISFFAVPFRTVQLPGSNSTIGP 252

  Fly   386 KSDAEMAKGFLGYNATLFKNNLFADYRPE-KGGIQHDFFSVFAIFFPAATGILAGANISGDLKDP 449
            .     ...|.|:.......||.|||..: .......|.:|||:.|...|||:||:|:|||||:|
Zfish   253 S-----RANFTGFKLDTLTGNLQADYTLDYTTKAMMSFATVFAVMFNGCTGIMAGSNMSGDLKNP 312

  Fly   450 QKSIPKGTILAIVITTGTYLIMVLQCGATVARDATGNLSDVVNGTFAFLDCQPGECNYGLQNSFQ 514
            ..|||:|||.|::.|...|.::.|....|..|..                         ||..:.
Zfish   313 SYSIPRGTITAVIFTFIIYNLLSLLISCTCDRIL-------------------------LQKDYG 352

  Fly   515 VIELVSAFGPLIYAGCYAATLSSALASLVSAPKVFQALCKDELYPKIVWFAKGYGKNNEPVRGYV 579
            .:..::.:||.:..|.|::|||:|:::|:.|.::..||.||:|:.:::..||....:..|....:
Zfish   353 FLRDINVWGPFVTVGVYSSTLSAAMSNLIGASRILFALAKDDLFGRVLSPAKRTSASGNPWVSVL 417

  Fly   580 LTFIIACAFILIGELNLIAPLISNFFLAAYMLINFSTFHASLAKPVGWRPTFKYYNMWLSLLGAI 644
            :::.:....:..|:||.||.:::.|||..|..::.:......|....:||||:|:.....:||.|
Zfish   418 ISWFLVQLVLFSGKLNTIASIVTIFFLLVYAAVDLACLALEWASAPNFRPTFRYFTWHTCVLGII 482

  Fly   645 LCVAVMFLISWATALITFAAVLALYLIVAYRKPDVNWGSTTQAQTYKNALMSVQQLNNVEEHVKN 709
            .|..:||||:...|..:.|.:|.|.|::.|..|..:||..:||..:......:..|:..::|||.
Zfish   483 GCAVMMFLINAIYASASIAFMLLLLLLIHYLSPVSSWGCISQALIFHQVRKYLLMLDVRKDHVKF 547

  Fly   710 YRPQILVLSGLPNTRPVLVDLAYMLTKNLSLLVCGHVLKGSSSQKYRTYLQERAGNWFR--KH-R 771
            :|||:|::...|.:...|:.....:.|: .|.|.|||..|.........||.:..:|..  .| .
Zfish   548 WRPQVLLMVSNPRSSVGLITFINHIKKS-GLYVLGHVQLGDLDVLPSDPLQAQYDSWLSLVDHLN 611

  Fly   772 VKGFYALVDGEDFESGTRALMQATGIGKLKPNIILMGYKTDWQTCDHKELDQYFNVMHKALDMYL 836
            :|.|..|...:....|.:.|:..:|:|.::||.:::|:..|
Zfish   612 IKAFVNLTLADSIRHGVQHLLFISGLGGMRPNTLVLGFYDD------------------------ 652

  Fly   837 SVAILRVPQGLDCSQVLGSQDGWKTVSDVPRTLQPNESSGDLQAVDSSVRNGLSGSIDSLSRNVS 901
                            ...||                     |..|||:  .:|..:|:.|:|..
Zfish   653 ----------------ASPQD---------------------QLQDSSL--SMSKFLDNSSQNED 678

  Fly   902 QEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGNQSKDVSGMPDPLDAK 966
            .||:        ::.......:|....:.|...|.|.:....:...|.               |.
Zfish   679 PEDQ--------DEPPFHFPPVRGGVAVGRGAVWGGKSLGPQEYVCII---------------AD 720

  Fly   967 SANLVSNSLRKSKLKHDDPASLYKGPGGAELPKEVLADL--TQFTRKRSHAVIDVWWLYDDGGLT 1029
            :..::.|..........|.....:||        :..|:  ....|..|.|.:|...|:     .
Zfish   721 AVKMLKNVALARYFGQFDHTHALQGP--------IFVDVWPVNLLRPDSAAYVDTCSLF-----L 772

  Fly  1030 LLLPYIISTRRTWQSCKLRVYALANKNSELEFEQRSMASLLSKFRIDYSDLTLIP---------- 1084
            |.|..|::..|.||..:||::....:...|:..::.:..||...|:. :|:..:|
Zfish   773 LQLACILNMTRAWQKARLRLFLCVEEGRSLKGTEQKLGHLLKDLRMK-ADICTVPWDSEVALHWQ 836

  Fly  1085 -----DITKKPQETSTQFFNELIKDFVVTEKDGENGTSSRATLNEDDALITDDDLLAVQDKTNRY 1144
                 |..:|.:|..::      :..|..:|...|...|      :.:.::|:.|.||..
Zfish   837 RQTRLDRNEKEEELESE------EGGVEADKFFSNSFPS------NTSRVSDEYLQAVNK----- 884

  Fly  1145 LRLREYLREQSTKSDLVVMTLPMPRKNIVSAPLYMAWLESLSRDMPPFLFVRGNQTSVLT 1204
            |.|.:.||..:.:    .:.||.|..:......|:..||.|:||:.|.|.:.| .|.|:|
Zfish   885 LILEQKLRPPAVR----FLYLPRPPADTSRYSDYLNQLELLTRDLGPTLLIHG-VTPVIT 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588	7/25 (28%)
		2a30	155..1207	CDD:273347	283/1099 (26%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	47/157 (30%)
		SLC12	724..1207	CDD:281515	94/500 (19%)
zgc:153039	XP_021337145.1	SLC12	12..933	CDD:332077	275/1081 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910