Protein Alignment Ncc69 and Slc12a6

DIOPT Version :10

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: NP_001103100.1
• Gene: Slc12a6 / 691209
• RGDID: 1311335
• Length: 1150
• Species: Rattus norvegicus
• Alignment Length: 1338
• Identity: 329/1338 - (24%)
• Similarity: 530/1338 - (39%)
• Gaps: 425/1338 - (31%)

  Fly    78 DATQMLNQRQPRQQRQSIKSSFRDKDKPSRFKDLQTTT----RFQVDPQN----------EESDE 128
            |.:..|:.|...:.|.|.:.|..:..:.....:|...|    ...:||.:          |:.::
  Rat    30 DTSPDLSSRSSSRVRFSSRESVPETSRSEPMSELSGATTSLATVALDPSSDRTSNPQDVTEDPNQ 94

  Fly   129 SNDSQEERELLDN----------------EYDTKYGKSFRHFTRE---------ALPRLDNYRNM 168
            ::.:.|..:|||:                |.|..:.|:...|..|         .|.|:.||.|:
  Rat    95 NSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNL 159

  Fly   169 MSIQAAYRPTLDELHNATLVGKNTHSLTRNQDPESGILNGVLKFGWIKGVLVRCLLNIWGVMLFL 233
              .|.|...  :|..|.| .||...:    :.|:         .|...||.:.||.||:||:|||
  Rat   160 --TQGAKEH--EEAENIT-EGKKKPT----KSPQ---------MGTFMGVYLPCLQNIFGVILFL 206

  Fly   234 RLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMISRSLGPEFGGSIGLI 298
            ||:||||.|||::.|.::|.....|.:||:|||||:||||:..||:|:||||:|||||||::||.
  Rat   207 RLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLC 271

  Fly   299 FSLANAVACAMYVVGFCESML--------------------AMMTTFGWEIIDGGVQDVRIIGCI 343
            |.|....|.|||::|..|..|                    ||:            .::|:.|..
  Rat   272 FYLGTTFAAAMYILGAIEIFLVYIVPRAAIFRSDDALKESAAML------------NNMRVYGTA 324

  Fly   344 TILLLLIIVVVGMEWE---AKAQIGLLIILLVAIGDFVIGSFIGP-------------------- 385
            .::|::::|.:|:.:.   |...:..:|:.::||....|.|...|
  Rat   325 FLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHLDI 389

  Fly   386 ------------------------------------KSDAEMAKGFLGYNATLFKNNLFADYRP- 413
                                                .::....:|..|..:.:...||:::|.|
  Rat   390 CSKTKEVNNMTIPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPK 454

  Fly   414 ----EK---------GGIQHD---------FFSVFAIFFPAATGILAGANISGDLKDPQKSIPKG 456
                ||         |.:.|:         |..:..||||:.|||:||:|.||||||.|||||.|
  Rat   455 GEIIEKPSAKSSDVLGNLNHEYVLADITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIG 519

  Fly   457 TILAIVITTGTYLIMVLQCGA----TVARDATGNLSDVVNGTFAFLDCQPGECNYGLQNSFQVIE 517
            |||||:.|:..||..|:..||    .|.||..|   |.|.|..                   |:.
  Rat   520 TILAILTTSFVYLSNVVLFGACIEGVVLRDKFG---DAVKGNL-------------------VVG 562

  Fly   518 LVSAFGP-LIYAGCYAATLSSALASLVSAPKVFQALCKDELYPKIVWFAKGYGK-NNEPVRGYVL 580
            .:|...| :|..|.:.:|..:.|.||..||::.||:.||.:.|.:..|  |:.| |.||....:|
  Rat   563 TLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHSKANGEPTWALLL 625

  Fly   581 TFIIACAFILIGELNLIAPLISNFFLAAYMLINFSTFHASLAKPVGWRPTFKYYNMWLSLLGAIL 645
            |..||...|||..|:|:||::|.|||..|:.:|.:....:|.:...|||.|:||:..||.:|..:
  Rat   626 TAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPHWRPRFRYYHWALSFMGMSI 690

  Fly   646 CVAVMFLISWATALITFAAVLALYLIVAYRKPDVNWGSTTQAQTYKNALMSVQQLNNVEEHVKNY 710
            |:|:||:.||..|::.......:|..:.|:..:..||...:..:...|..::.:|.....|.||:
  Rat   691 CLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNW 755

  Fly   711 RPQILVLSGLPN----TRPVLVDLAYMLTKNLSLLVCGHVLKGSSSQKYRTYL--QERAGNWFRK 769
            |||:|||..|..    ..|.|:..|..|.....|.:.|.|:.|:..:.|...|  ::...:....
  Rat   756 RPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGDALAAEQTIKHLMEA 820

  Fly   770 HRVKGFYALVDGEDFESGTRALMQATGIGKLKPNIILMGYKTDWQTCDHKELDQYFNVMHKALDM 834
            .:||||..||.....:.|...|:|:.|:|.:|.|.::||:...|:.
  Rat   821 EKVKGFCQLVVAAKLKEGISHLIQSCGLGGMKHNTVVMGWPNGWRQ------------------- 866

  Fly   835 YLSVAILRVPQGLDCSQVLGSQD--GWKTVSDVPRTLQPNESSGDLQAVDSSVRNGLSGSIDSLS 897
                                |:|  .|||.....|
  Rat   867 --------------------SEDARAWKTFIGTVR------------------------------ 881

  Fly   898 RNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGNQSKDVSGMPDP 962
                                                     .::.:.|:.:.   :|:||..|
  Rat   882 -----------------------------------------VTTAAHLALLV---AKNVSFFP-- 900

  Fly   963 LDAKSANLVSNSLRKSKLKHDDPASLYKGPGGAELPKEVLADLTQFTRKRSHAVIDVWWLYDDGG 1027
                                                    :::.||    |...|||||:..|||
  Rat   901 ----------------------------------------SNVEQF----SEGNIDVWWIVHDGG 921

  Fly  1028 LTLLLPYIISTRRTWQSCKLRVYALANKNSELEFEQRSMASLLSKFRIDY---------SDL--- 1080
            :.:|||:::...:.|:.|.:|::.:|.........::.:|:.|...||:.         ||:
  Rat   922 MLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAY 986

  Fly  1081 ----TLIPD----------ITKKPQETSTQFFNELIKD--------FVVTEKDGENGT---SSRA 1120
                ||:.:          ::|..::...|    |:||        .:.:::|.|..|   ....
  Rat   987 TYERTLMMEQRSQMLRHMRLSKTERDREAQ----LVKDRNSMLRLTSIGSDEDEETETYQEKVHM 1047

  Fly  1121 TLNEDDALITD----------DDLLAVQ-DKTN-----RYLRLREYLREQSTKSDLVVMTLPMPR 1169
            |..:|..:.:.          .|||.:: |::|     ..::|.|.:..:|.::.||::.:|.|.
  Rat  1048 TWTKDKYMASRGQKVKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPP 1112

  Fly  1170 KNIVSAPLYMAWLESLSRDMPPFLFVRGNQTSVLTFYS 1207
            :|......||.:||.|:..:...|.|||..:.|:|.||
  Rat  1113 RNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1150

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_2	155..1207	CDD:459263	308/1229 (25%)
Slc12a6	NP_001103100.1	2a30	109..1150	CDD:273347	312/1257 (25%)