Protein Alignment Ncc69 and SLC12A4

DIOPT Version :10

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: NP_001139434.1
• Gene: SLC12A4 / 6560
• HGNCID: 10913
• Length: 1087
• Species: Homo sapiens
• Alignment Length: 1346
• Identity: 327/1346 - (24%)
• Similarity: 517/1346 - (38%)
• Gaps: 429/1346 - (31%)

  Fly    31 KSQGADGPG-SGSGAGAGAGAGAGEDGPHEVYRRLTNAEGELLEDDTFDATQMLNQRQPRQQRQS 94
            ::.||..|| :|:.||..||...|..|..|..|.||:                     |..|
Human     2 RAGGACRPGAAGTAAGTAAGGWDGGCGGAEPARCLTS---------------------PWCQ--- 42

  Fly    95 IKSSFRDKDKPSRFKDLQTTTRFQVDPQNEESDESNDSQEERELLDNEYDTKYGKSFRHFTREAL 159
                     ...|.....||:|..|......:.......||.::             |......|
Human    43 ---------WTGRGAATMTTSRGSVGWTTGSAPSWMTRTEELDI-------------RPKVSSLL 85

  Fly   160 PRLDNYRNMMSIQAAYRPTLDELHNATLVGKNTHSLTRNQDPESGILNGVLK-------FGWIKG 217
            .:|.:|.|:                       |.....:::.|||  .|..:       .|.:.|
Human    86 GKLVSYTNL-----------------------TQGAKEHEEAESG--EGTRRRAAEAPSMGTLMG 125

  Fly   218 VLVRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYM 282
            |.:.||.||:||:|||||:|:||.|||::..:::|.....|.:||:|||||:||||:..||:|:|
Human   126 VYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFM 190

  Fly   283 ISRSLGPEFGGSIGLIFSLANAVACAMYVVGFCESMLAMMTTFGWEIIDGGVQD--------VRI 339
            |||||||||||::||.|.|....|.|||::|..|.:|..:..........|..|        :|:
Human   191 ISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRV 255

  Fly   340 IGCITILLLLIIVVVGMEWEAKAQIGLLIILLVAIGDFVIGS-------------FIGPKS---- 387
            .|.|.:..:.::|.||:::..|.....|..::::|.....|.             .:|.::
Human   256 YGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRD 320

  Fly   388 -----------DAEMA-------------------------------KGFLGYNATLFKNNLFAD 410
                       |.|..                               .|..|..|.:.:.||::.
Human   321 QFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSA 385

  Fly   411 YRPEKGGI--QH------------------------DFFSVFAIFFPAATGILAGANISGDLKDP 449
            |. |||.|  :|                        .|..:..||||:.|||:||:|.||||:|.
Human   386 YL-EKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDA 449

  Fly   450 QKSIPKGTILAIVITTGTYLIMVLQCGA----TVARDATGN--LSDVVNGTFAFLDCQPGECNYG 508
            |||||.||||||:.|:..|...|:..||    .|.||..|:  ..::|.||.|:    |...
Human   450 QKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAW----PSPW--- 507

  Fly   509 LQNSFQVIELVSAFGPLIYAGCYAATLSSALASLVSAPKVFQALCKDELYPKIVWFAKGYGK-NN 572
                            :|..|.:.:|..:.|.||..||::.||:.||.:.|.:..|  |:|| |.
Human   508 ----------------VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHGKVNG 554

  Fly   573 EPVRGYVLTFIIACAFILIGELNLIAPLISNFFLAAYMLINFSTFHASLAKPVGWRPTFKYYNMW 637
            ||....:||.:||...|||..|:::||::|.|||..|:.:|.:....:|.:...|||.||||:..
Human   555 EPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWA 619

  Fly   638 LSLLGAILCVAVMFLISWATALITFAAVLALYLIVAYRKPDVNWGSTTQAQTYKNALMSVQQLNN 702
            ||.||..||:|:||:.||..||:.......:|..:.|:..:..||...:..:...|..::.:|..
Human   620 LSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEE 684

  Fly   703 VEEHVKNYRPQILVLSGLPN----TRPVLVDLAYMLTKNLSLLVCGHVLKGSSSQKY--RTYLQE 761
            ...|.||:|||:|||..|..    ..|.|:..|..|.....|.:.|.|::||..:.|  ....::
Human   685 GPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 749

  Fly   762 RAGNWFRKHRVKGFYALVDGEDFESGTRALMQATGIGKLKPNIILMGYKTDWQTCDHKELDQYFN 826
            ...|.....:||||..:|.......|...|:|:.|:|.::.|.:::|:...|:.
Human   750 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQ----------- 803

  Fly   827 VMHKALDMYLSVAILRVPQGLDCSQVLGSQD--GWKTVSDVPRTLQPNESSGDLQAVDSSVRNGL 889
                                        |:|  .|||..|..|
Human   804 ----------------------------SEDPRAWKTFIDTVR---------------------- 818

  Fly   890 SGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGNQSK 954
                                ...:...:|.:.|                     :::|...|..:
Human   819 --------------------CTTAAHLALLVPK---------------------NIAFYPSNHER 842

  Fly   955 DVSGMPDPLDAKSANLVSNSLRKSKLKHDDPASLYKGPGGAELPKEVLADLTQFTRKRSHAVIDV 1019
            .:.|                                                       |  |||
Human   843 YLEG-------------------------------------------------------H--IDV 850

  Fly  1020 WWLYDDGGLTLLLPYIISTRRTWQSCKLRVYALANKNSELEFEQRSMASLLSKFRID-------- 1076
            ||:..|||:.:|||:::...:.|:.|::|::.:|..:......::.:|..|...|::
Human   851 WWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEM 915

  Fly  1077 -YSDL-------TLIPD----------ITKKPQETSTQFFNELIKD--------FVVTEKDGENG 1115
             .||:       ||:.:          :||..:|...|    |:||        .:.::::.|:.
Human   916 HNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQ----LVKDRHSALRLESLYSDEEDESA 976

  Fly  1116 TSS---RATLNEDDALITDDD----------LLAVQ-DKTN-----RYLRLREYLREQSTKSDLV 1161
            ..:   :.|...|..:....|          |:.:: |::|     ..::|.|.:..:|..:.||
Human   977 VGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLV 1041

  Fly  1162 VMTLPMPRKNIVSAPLYMAWLESLSRDMPPFLFVRGNQTSVLTFYS 1207
            ::.:|.|.:|......||.:||.|:..:...|.|||....|:|.||
Human  1042 LLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_2	155..1207	CDD:459263	300/1219 (25%)
SLC12A4	NP_001139434.1	2a30	70..1087	CDD:273347	303/1243 (24%)