DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ncc69 and SLC12A4

DIOPT Version :9

Sequence 1:NP_001261758.1 Gene:Ncc69 / 39410 FlyBaseID:FBgn0036279 Length:1207 Species:Drosophila melanogaster
Sequence 2:NP_001139434.1 Gene:SLC12A4 / 6560 HGNCID:10913 Length:1087 Species:Homo sapiens


Alignment Length:1349 Identity:327/1349 - (24%)
Similarity:517/1349 - (38%) Gaps:435/1349 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 KSQGADGPG-SGSGAGAGAGAGAGEDGPHEVYRRLTNAEGELLEDDTFDATQMLNQRQPRQQRQS 94
            ::.||..|| :|:.||..||...|..|..|..|.||:                     |..|   
Human     2 RAGGACRPGAAGTAAGTAAGGWDGGCGGAEPARCLTS---------------------PWCQ--- 42

  Fly    95 IKSSFRDKDKPSRFKDLQTTTRFQVDPQNEESDESNDSQEERELLDNEYDTKYGKSFRHFTREAL 159
                     ...|.....||:|..|......:.......||.::             |......|
Human    43 ---------WTGRGAATMTTSRGSVGWTTGSAPSWMTRTEELDI-------------RPKVSSLL 85

  Fly   160 PRLDNYRNMMSIQAAYRPTLDELHNATLVGKNTHSLTRNQDPESGILNGVLK-------FGWIKG 217
            .:|.:|.|:                       |.....:::.|||  .|..:       .|.:.|
Human    86 GKLVSYTNL-----------------------TQGAKEHEEAESG--EGTRRRAAEAPSMGTLMG 125

  Fly   218 VLVRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYM 282
            |.:.||.||:||:|||||:|:||.|||::..:::|.....|.:||:|||||:||||:..||:|:|
Human   126 VYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFM 190

  Fly   283 ISRSLGPEFGGSIGLIFSLANAVACAMYVVGFCESMLAMMTTFGWEIIDGGVQD--------VRI 339
            |||||||||||::||.|.|....|.|||::|..|.:|..:..........|..|        :|:
Human   191 ISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRV 255

  Fly   340 IGCITILLLLIIVVVGMEWEAKAQIGLLIILLVAIGDFVIGS-------------FIGPKS---- 387
            .|.|.:..:.::|.||:::..|.....|..::::|.....|.             .:|.::    
Human   256 YGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRD 320

  Fly   388 -----------DAEMA-------------------------------KGFLGYNATLFKNNLFAD 410
                       |.|..                               .|..|..|.:.:.||::.
Human   321 QFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSA 385

  Fly   411 YRPEKGGI--QH------------------------DFFSVFAIFFPAATGILAGANISGDLKDP 449
            |. |||.|  :|                        .|..:..||||:.|||:||:|.||||:|.
Human   386 YL-EKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDA 449

  Fly   450 QKSIPKGTILAIVITTGTYLIMVLQCGA----TVARDATGN--LSDVVNGTFAFLDCQPGECNYG 508
            |||||.||||||:.|:..|...|:..||    .|.||..|:  ..::|.||.|:           
Human   450 QKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAW----------- 503

  Fly   509 LQNSFQVIELVSAFGP---LIYAGCYAATLSSALASLVSAPKVFQALCKDELYPKIVWFAKGYGK 570
                           |   :|..|.:.:|..:.|.||..||::.||:.||.:.|.:..|  |:||
Human   504 ---------------PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHGK 551

  Fly   571 -NNEPVRGYVLTFIIACAFILIGELNLIAPLISNFFLAAYMLINFSTFHASLAKPVGWRPTFKYY 634
             |.||....:||.:||...|||..|:::||::|.|||..|:.:|.:....:|.:...|||.||||
Human   552 VNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYY 616

  Fly   635 NMWLSLLGAILCVAVMFLISWATALITFAAVLALYLIVAYRKPDVNWGSTTQAQTYKNALMSVQQ 699
            :..||.||..||:|:||:.||..||:.......:|..:.|:..:..||...:..:...|..::.:
Human   617 HWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLR 681

  Fly   700 LNNVEEHVKNYRPQILVLSGLPN----TRPVLVDLAYMLTKNLSLLVCGHVLKGSSSQKY--RTY 758
            |.....|.||:|||:|||..|..    ..|.|:..|..|.....|.:.|.|::||..:.|  ...
Human   682 LEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQA 746

  Fly   759 LQERAGNWFRKHRVKGFYALVDGEDFESGTRALMQATGIGKLKPNIILMGYKTDWQTCDHKELDQ 823
            .::...|.....:||||..:|.......|...|:|:.|:|.::.|.:::|:...|:.        
Human   747 AEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQ-------- 803

  Fly   824 YFNVMHKALDMYLSVAILRVPQGLDCSQVLGSQD--GWKTVSDVPRTLQPNESSGDLQAVDSSVR 886
                                           |:|  .|||..|..|                   
Human   804 -------------------------------SEDPRAWKTFIDTVR------------------- 818

  Fly   887 NGLSGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGN 951
                                   ...:...:|.:.|                     :::|...|
Human   819 -----------------------CTTAAHLALLVPK---------------------NIAFYPSN 839

  Fly   952 QSKDVSGMPDPLDAKSANLVSNSLRKSKLKHDDPASLYKGPGGAELPKEVLADLTQFTRKRSHAV 1016
            ..:.:.|                                                       |  
Human   840 HERYLEG-------------------------------------------------------H-- 847

  Fly  1017 IDVWWLYDDGGLTLLLPYIISTRRTWQSCKLRVYALANKNSELEFEQRSMASLLSKFRID----- 1076
            |||||:..|||:.:|||:::...:.|:.|::|::.:|..:......::.:|..|...|::     
Human   848 IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEV 912

  Fly  1077 ----YSDL-------TLIPD----------ITKKPQETSTQFFNELIKD--------FVVTEKDG 1112
                .||:       ||:.:          :||..:|...|    |:||        .:.::::.
Human   913 VEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQ----LVKDRHSALRLESLYSDEED 973

  Fly  1113 ENGTSS---RATLNEDDALITDDD----------LLAVQ-DKTN-----RYLRLREYLREQSTKS 1158
            |:...:   :.|...|..:....|          |:.:: |::|     ..::|.|.:..:|..:
Human   974 ESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDA 1038

  Fly  1159 DLVVMTLPMPRKNIVSAPLYMAWLESLSRDMPPFLFVRGNQTSVLTFYS 1207
            .||::.:|.|.:|......||.:||.|:..:...|.|||....|:|.||
Human  1039 RLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ncc69NP_001261758.1 AA_permease_N 144..>183 CDD:285588 5/38 (13%)
2a30 155..1207 CDD:273347 300/1222 (25%)
ArsB_NhaD_permease <524..>682 CDD:304373 60/161 (37%)
SLC12 724..1207 CDD:281515 92/539 (17%)
SLC12A4NP_001139434.1 2a30 70..1087 CDD:273347 303/1246 (24%)
SLC5-6-like_sbd 144..>305 CDD:294310 57/160 (36%)
SLC12 711..1087 CDD:281515 92/538 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158226
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG57166
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.850

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