DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ncc69 and SLC12A3

DIOPT Version :9

Sequence 1:	NP_001261758.1	Gene:	Ncc69 / 39410	FlyBaseID:	FBgn0036279	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_000330.3	Gene:	SLC12A3 / 6559	HGNCID:	10912	Length:	1030	Species:	Homo sapiens

Alignment Length:	1128	Identity:	452/1128 - (40%)
Similarity:	655/1128 - (58%)	Gaps:	174/1128 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 SDESN-----DSQEERELLDNEYDTKYGKSFRHFTREALPRLDNYRNMMSIQAA----YRPTLDE 181
            |||.:     ||.....|..:  .|...::|.:.|.:.:|..::|.|  |.|..    .||||.:
Human    28 SDEPSPPAAYDSSHPSHLTHS--STFCMRTFGYNTIDVVPTYEHYAN--STQPGEPRKVRPTLAD 88

  Fly   182 LHN-ATLVGKNTHSLTRNQDPESGILNGV----------------LKFGWIKGVLVRCLLNIWGV 229
            ||: ....|::.|:|..:..|...:.:|:                ::|||:|||::||:||||||
Human    89 LHSFLKQEGRHLHALAFDSRPSHEMTDGLVEGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGV 153

  Fly   230 MLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMISRSLGPEFGGS 294
            :|:|||.|:..|||::..:::||.:..||:||.||:|||||||.:|.||||::||||||||.|||
Human   154 ILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGS 218

  Fly   295 IGLIFSLANAVACAMYVVGFCESMLAMMTTFGWEIIDGGVQDVRIIGCITILLLLIIVVVGMEWE 359
            |||||:.||||..||:.|||.|::..::..:|..|:| .:.|:|||..:::.:||.|.:.|||||
Human   219 IGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVD-PINDIRIIAVVSVTVLLAISLAGMEWE 282

  Fly   360 AKAQIGLLIILLVAIGDFVIGSFIGPKSDAEMAKGFLGYNATLFKNNLFADYRPEKGGIQHDFFS 424
            :|||:...::::|:..::::|:.|.|..| :.:|||..|.|.:|..||..|:|...|    .||.
Human   283 SKAQVLFFLVIMVSFANYLVGTLIPPSED-KASKGFFSYRADIFVQNLVPDWRGPDG----TFFG 342

  Fly   425 VFAIFFPAATGILAGANISGDLKDPQKSIPKGTILAIVITTGTYLIMVLQCGATVARDATGNLSD 489
            :|:||||:|||||||||||||||||..:|||||::||..||.:||.:....|:.|.|||:|.|:|
Human   343 MFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLND 407

  Fly   490 VVNGTFA------------FLDC-QPGECNYGLQNSFQVIELVSAFGPLIYAGCYAATLSSALAS 541
            .|...:.            |.:| |...|:|||.|.:|.:.:||.|.|||.||.:.||||||||.
Human   408 TVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALAC 472

  Fly   542 LVSAPKVFQALCKDELYPKIVWFAKGYGKNNEPVRGYVLTFIIACAFILIGELNLIAPLISNFFL 606
            ||||.||||.||:|:|||.|.:|.||||||.||||||:|.:.||.|||:|.|||.|||:||||||
Human   473 LVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFL 537

  Fly   607 AAYMLINFSTFHASLAKPVGWRPTFKYYNMWLSLLGAILCVAVMFLISWATALITFAAVLALYLI 671
            .:|.|||||.||||:....||||:|:|||.|.:|.|||:.|.:|||::|..|||....||.|.|.
Human   538 CSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLY 602

  Fly   672 VAYRKPDVNWGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQILVLSGLPNTRPVLVDLAYMLTK 736
            |.|:||:|||||:.||.:|..||.....||.||:|:||||||.|||:|.||.||.|||.....|:
Human   603 VIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTR 667

  Fly   737 NLSLLVCGHVLKGSSSQKYRTYLQERAG---NWFRKHRVKGFYALVDGEDFESGTRALMQATGIG 798
            ||||::|||||.|...|: ...||..|.   .|..|.::|.||:.|..||...|.:.||||.|:|
Human   668 NLSLMICGHVLIGPHKQR-MPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLG 731

  Fly   799 KLKPNIILMGYKTDWQTCDHKELDQYFNVMHKALDMYLSVAILRVPQGLDCSQVLGSQDGWKTVS 863
            ::||||:::|:|.:||:.....::.|..::|.|.|....|.::|:.:||:.|:::.:.
Human   732 RMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAH------- 789

  Fly   864 DVPRTLQPNESSGDLQAVDSSVRNGLSGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRFKQG 928
             :.....|.|...:..|                                              :|
Human   790 -INPVFDPAEDGKEASA----------------------------------------------RG 807

  Fly   929 LRRMRSWPGAASSTSDLSFIAGNQSKDVSGMPDPLDAKSANLVSNSLRKSKLKHDDPASLYKGPG 993
            .|                       ..|||..||              |:.:|.:...::::...
Human   808 AR-----------------------PSVSGALDP--------------KALVKEEQATTIFQSEQ 835

  Fly   994 GAELPKEVLADLTQFTRKRSHAVIDVWWLYDDGGLTLLLPYIISTRRTWQSCKLRVYALANKNSE 1058
            |.:                   .||::||:||||||||:||::..:|.|..||:||: :..:.:.
Human   836 GKK-------------------TIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVF-VGGQINR 880

  Fly  1059 LEFEQRSMASLLSKFRIDYSDLTLIPDITKKPQETSTQFFNELIKDFVVTEKDGENGTSSRATLN 1123
            ::.|::::.|||||||:.:.::.::|||.:.|:...|:.|.::|..|.:.:     |....||:|
Human   881 MDQERKAIISLLSKFRLGFHEVHILPDINQNPRAEHTKRFEDMIAPFRLND-----GFKDEATVN 940

  Fly  1124 E--DDA--LITDDDLLAVQDKTNRYLRLREYLREQSTKSDLVVMTLPMPRKNIVSAPLYMAWLES 1184
            |  .|.  .|:|:::...:.|:.|.:||.|.:.:.|..:.|:|:|||:.||....:.|||||||:
Human   941 EMRRDCPWKISDEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLET 1005

  Fly  1185 LSRDM-PPFLFVRGNQTSVLTFY 1206
            ||:|: ||.:.:||||.:|||||
Human  1006 LSQDLRPPVILIRGNQENVLTFY 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588	12/42 (29%)
		2a30	155..1207	CDD:273347	444/1094 (41%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	101/157 (64%)
		SLC12	724..1207	CDD:281515	143/491 (29%)
SLC12A3	NP_000330.3	2a30	59..1029	CDD:273347	444/1095 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158227
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2083
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D135130at33208
OrthoFinder	1	1.000	-	-		FOG0001536
OrthoInspector	1	1.000	-	-		mtm8484
orthoMCL	1	0.900	-	-		OOG6_101360
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5652
SonicParanoid	1	1.000	-	-		X709
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.750