DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ncc69 and SLC12A2

DIOPT Version :9

Sequence 1:NP_001261758.1 Gene:Ncc69 / 39410 FlyBaseID:FBgn0036279 Length:1207 Species:Drosophila melanogaster
Sequence 2:NP_001037.1 Gene:SLC12A2 / 6558 HGNCID:10911 Length:1212 Species:Homo sapiens


Alignment Length:1271 Identity:559/1271 - (43%)
Similarity:758/1271 - (59%) Gaps:196/1271 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 GSAADRP------PNRFQVNPVNGNSRKSQGADGPGSGSGAGAGAGAGAGEDGPHEVYRRLTNAE 68
            |....||      .:||||:.|:.|:.::..|....:.:.|.|||||||          :.|.|:
Human    65 GDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGA----------KQTPAD 119

  Fly    69 GELLEDDTFDATQMLNQRQPRQQRQSIKSSFR----DKDKPSRFKD-LQTTTRFQVDPQNEESDE 128
            ||           ...:.:|.:..:..|..||    |....|..:| |.......||..|.....
Human   120 GE-----------ASGESEPAKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQN 173

  Fly   129 SNDS-----------------QEERELLDNEYDTKYGKSFRHFTREALPRLDNYRNMMSI--QAA 174
            ..|:                 ..:....|...:|.|.::|.|.|.:|:||:|:||:..:.  :..
Human   174 GGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKL 238

  Fly   175 YRPTLDELHNATLVGKNTHSLTRNQDP-ESGILN-------------------GVLKFGWIKGVL 219
            .||:|.|||:..           .::| |.|..|                   ||:|||||||||
Human   239 LRPSLAELHDEL-----------EKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVL 292

  Fly   220 VRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMIS 284
            |||:|||||||||:||||:|||||:....::|:..|.|||||.||.|||:|||.::|||.||:||
Human   293 VRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLIS 357

  Fly   285 RSLGPEFGGSIGLIFSLANAVACAMYVVGFCESMLAMMTTFGWEIIDGGVQDVRIIGCITILLLL 349
            |||||||||:|||||:.|||||.|||||||.|:::.::......:|| .:.|:||||.||:::||
Human   358 RSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMID-EINDIRIIGAITVVILL 421

  Fly   350 IIVVVGMEWEAKAQIGLLIILLVAIGDFVIGSFIGPKSDAEMAKGFLGYNATLFKNNLFADYRPE 414
            .|.|.||||||||||.||:|||:||||||||:||  ..:::..|||.||.:.:|..|...|:|.|
Human   422 GISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFI--PLESKKPKGFFGYKSEIFNENFGPDFREE 484

  Fly   415 KGGIQHDFFSVFAIFFPAATGILAGANISGDLKDPQKSIPKGTILAIVITTGTYLIMVLQCGATV 479
            :     .|||||||||||||||||||||||||.|||.:|||||:|||:|||..|:.:.:..|:.|
Human   485 E-----TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCV 544

  Fly   480 ARDATGNLSDVV-----NGT-------FAFLDCQPGECNYGLQNSFQVIELVSAFGPLIYAGCYA 532
            .||||||::|.:     |.|       |.|..|:...|:|||.|:|||:.:||.|.|||.||.::
Human   545 VRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISAGIFS 609

  Fly   533 ATLSSALASLVSAPKVFQALCKDELYPKIVWFAKGYGKNNEPVRGYVLTFIIACAFILIGELNLI 597
            |||||||||||||||:|||||||.:||....|||||||||||:|||:|||:||..||||.|||:|
Human   610 ATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVI 674

  Fly   598 APLISNFFLAAYMLINFSTFHASLAKPVGWRPTFKYYNMWLSLLGAILCVAVMFLISWATALITF 662
            ||:|||||||:|.|||||.|||||||..||||.|||||||:||||||||..|||:|:|..||:|:
Human   675 APIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGAILCCIVMFVINWWAALLTY 739

  Fly   663 AAVLALYLIVAYRKPDVNWGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQILVLSGLPNTRPVL 727
            ..||.||:.|.|:||||||||:|||.||.|||....:|:.||:||||:|||.||::|.||:||.|
Human   740 VIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVMTGAPNSRPAL 804

  Fly   728 VDLAYMLTKNLSLLVCGHVLKGSSSQ--KYRTYLQERAGNWFRKHRVKGFYALVDGEDFESGTRA 790
            :.|.:..|||:.|::||||..|...|  |..:..|.:...|..|:::|.|||.|..:|...|.:.
Human   805 LHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQY 869

  Fly   791 LMQATGIGKLKPNIILMGYKTDWQTCDHKELDQYFNVMHKALDMYLSVAILRVPQGLDCSQVLGS 855
            ||||.|:|::|||.:::|:|.||...|.:::|.|.|:.|.|.|:...|.::|:.:|||.|.:.|.
Human   870 LMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQ 934

  Fly   856 QDGWKTVSDVPRTLQPNESSGDLQAVDSSVRNGLSGSIDS--------LSRNVSQEDRNRNQLVH 912
            ::          .|...|.|...:.|..||.......:|:        ::..|.:||        
Human   935 EE----------LLSSQEKSPGTKDVVVSVEYSKKSDLDTSKPLSEKPITHKVEEED-------- 981

  Fly   913 SEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGNQSKDVSGMPDPLDAKSANLVSNSLRK 977
                                     ..::|..|      ..|:..|...||:.....|:..|   
Human   982 -------------------------GKTATQPL------LKKESKGPIVPLNVADQKLLEAS--- 1012

  Fly   978 SKLKHDDPASLYKGPGGAELPKEVLADLTQFTRKRSHAVIDVWWLYDDGGLTLLLPYIISTRRTW 1042
                                        |||.:|:....||||||:||||||||:||:::|::.|
Human  1013 ----------------------------TQFQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKW 1049

  Fly  1043 QSCKLRVYALANKNSELEFEQRSMASLLSKFRIDYSDLTLIPDITKKPQETSTQFFNELIKDFVV 1107
            :.||:||: :..|.:.::.::|:||:||||||||:||:.::.||..||::.:...|.|:|:.:.:
Human  1050 KDCKIRVF-IGGKINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENIIAFEEIIEPYRL 1113

  Fly  1108 TEKDGENGTSSRATLNEDDA-LITDDDLLAVQDKTNRYLRLREYLREQSTKSDLVVMTLPMPRKN 1171
            .|.|.|...:.:  :.||:. .|||::|...:.||.|.:||.|.|:|.|:.::::||:||:.||.
Human  1114 HEDDKEQDIADK--MKEDEPWRITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKG 1176

  Fly  1172 IVSAPLYMAWLESLSRDMPPFLFVRGNQTSVLTFYS 1207
            .||:.|||||||:||:|:||.|.||||..|||||||
Human  1177 AVSSALYMAWLEALSKDLPPILLVRGNHQSVLTFYS 1212

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ncc69NP_001261758.1 AA_permease_N 144..>183 CDD:285588 15/40 (38%)
2a30 155..1207 CDD:273347 518/1096 (47%)
ArsB_NhaD_permease <524..>682 CDD:304373 116/157 (74%)
SLC12 724..1207 CDD:281515 165/493 (33%)
SLC12A2NP_001037.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..81 3/15 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..138 8/46 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 150..193 7/42 (17%)
2a30 216..1212 CDD:273347 518/1097 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 962..989 5/59 (8%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158225
Domainoid 1 1.000 636 1.000 Domainoid score I170
eggNOG 1 0.900 - - E2759_KOG2083
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20283
Inparanoid 1 1.050 1007 1.000 Inparanoid score I289
Isobase 1 0.950 - 0 Normalized mean entropy S2360
OMA 1 1.010 - - QHG57166
OrthoDB 1 1.010 - - D135130at33208
OrthoFinder 1 1.000 - - FOG0001536
OrthoInspector 1 1.000 - - mtm8484
orthoMCL 1 0.900 - - OOG6_101360
Panther 1 1.100 - - LDO PTHR11827
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5652
SonicParanoid 1 1.000 - - X709
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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