Protein Alignment Ncc69 and SLC12A1

DIOPT Version :10

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: NP_000329.2
• Gene: SLC12A1 / 6557
• HGNCID: 10910
• Length: 1099
• Species: Homo sapiens
• Alignment Length: 1232
• Identity: 531/1232 - (43%)
• Similarity: 731/1232 - (59%)
• Gaps: 193/1232 - (15%)

  Fly    18 NRFQVNPVNGNSRKSQGADGPGSGSGAGAGAGAGAGEDGPHEVYRRLTNAEGELLEDDTFDATQM 82
            |||||:.:|.|...|..||.               ..|.||                  ::.|..
Human    19 NRFQVSVINENHESSAAADD---------------NTDPPH------------------YEETSF 50

  Fly    83 LNQRQPRQQRQSIKSSFRDKDKPSRFKDLQTTTRFQVDPQNEE-------SDESNDSQEERELLD 140
            .::.|.|     ::.|||                    |.|:|       |.|:..:.......|
Human    51 GDEAQKR-----LRISFR--------------------PGNQECYDNFLQSGETAKTDASFHAYD 90

  Fly   141 NEYDTKYGKSFRHFTREALPRLDNYRNMMSIQA--AYRPTLDELHN--ATLVGKNTHSLTR---- 197
            :..:|.|.::|.|.|.:|:|:::.|||..||..  ..||:|.|:|.  |..|.....|..|
Human    91 SHTNTYYLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVANG 155

  Fly   198 ----------NQDPESGILNGVLKFGWIKGVLVRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLIL 252
                      |::.:..   ||:||||:|||||||:|||||||||:||||:||:||:..|.::||
Human   156 DGIPGDEQAENKEDDQA---GVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIIL 217

  Fly   253 TTTAVTTITALSMSAISTNGVIKGGGTYYMISRSLGPEFGGSIGLIFSLANAVACAMYVVGFCES 317
            .:|.||:||.||.|||:|||.::|||.||:|||||||||||||||||:.|||||.|||||||.|:
Human   218 LSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAET 282

  Fly   318 MLAMMTTFGWEIIDGGVQDVRIIGCITILLLLIIVVVGMEWEAKAQIGLLIILLVAIGDFVIGSF 382
            ::.::......::| ...|:||||.||:::||.|.|.|||||||||:.||:|||:||.:|.||:.
Human   283 VVDLLKESDSMMVD-PTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTV 346

  Fly   383 IGPKSDAEMAKGFLGYNATLFKNNLFADYRPEKGGIQHDFFSVFAIFFPAATGILAGANISGDLK 447
            | |.::.:.::||..|.|::|..|....:...:|     |||||||||||||||||||||||||:
Human   347 I-PSNNEKKSRGFFNYQASIFAENFGPRFTKGEG-----FFSVFAIFFPAATGILAGANISGDLE 405

  Fly   448 DPQKSIPKGTILAIVITTGTYLIMVLQCGATVARDATGNLSDVV------NGTFA------FLDC 500
            |||.:||:||:|||.|||..||.:.:..||.|.||||||::|.:      ||:.|      |..|
Human   406 DPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRC 470

  Fly   501 QPGECNYGLQNSFQVIELVSAFGPLIYAGCYAATLSSALASLVSAPKVFQALCKDELYPKIVWFA 565
            :...|.|||.|:|||:.:||.|||||.||.::|||||||||||||||||||||||.:|..:.:||
Human   471 RHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFA 535

  Fly   566 KGYGKNNEPVRGYVLTFIIACAFILIGELNLIAPLISNFFLAAYMLINFSTFHASLAKPVGWRPT 630
            |||||||||:|||:|||:||.|||||.|||.|||:|||||||:|.|||||.||||.||..||||.
Human   536 KGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPA 600

  Fly   631 FKYYNMWLSLLGAILCVAVMFLISWATALITFAAVLALYLIVAYRKPDVNWGSTTQAQTYKNALM 695
            :..||||:||.||:||.||||:|:|..|:||:.....||:.|..:||||||||:|||.:|.:||.
Human   601 YGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALD 665

  Fly   696 SVQQLNNVEEHVKNYRPQILVLSGLPNTRPVLVDLAYMLTKNLSLLVCGHVLKGSSS---QKYRT 757
            :..:|..||:||||:|||.:||:|.|.|||.|:|:.:..|||..|.:|..|..|...   ::..:
Human   666 NALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNS 730

  Fly   758 YLQERAGNWFRKHRVKGFYALVDGEDFESGTRALMQATGIGKLKPNIILMGYKTDWQTCDHKELD 822
            .:.::.. |..|:::|.|||.|..:.|..|.|:|:||:|:|::|||.:::|||.:|:.....|::
Human   731 GMAKKQA-WLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIE 794

  Fly   823 QYFNVMHKALDMYLSVAILRVPQGLDCSQVLGSQDGWKTVSDVPRTLQPNESSGDLQAVDSSVRN 887
            .|..::|.|.|..:.|.|:|:.||.|.||||..|:
Human   795 NYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQE------------------------------ 829

  Fly   888 GLSGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGNQ 952
                                 :|...||..|                   |..:|     |..|:
Human   830 ---------------------ELERLEQERL-------------------ALEAT-----IKDNE 849

  Fly   953 SKDVSGMPDPLDAKSANLVSNSLRKSKLKHDDPASLYKGPGGAELPKEVLADLTQFTRKRSHAVI 1017
            .::.||....|..|:..|   ::.|:..|.|...:..:.....|..::::...|||.:|:....|
Human   850 CEEESGGIRGLFKKAGKL---NITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTI 911

  Fly  1018 DVWWLYDDGGLTLLLPYIISTRRTWQSCKLRVYALANKNSELEFEQRSMASLLSKFRIDYSDLTL 1082
            |||||:||||||||:|||::.|:.|:.||||:| :..|.:.:|.|:..||||||||||.::|:.:
Human   912 DVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIY-VGGKINRIEEEKIVMASLLSKFRIKFADIHI 975

  Fly  1083 IPDITKKPQETSTQFFNELIKDFVVTE--KDGENGTSSRATLNEDDALITDDDLLAVQDKTNRYL 1145
            |.||..:|.:.|.:.|.|:|:.:.:.|  ||   .|::.....|....|||.:|.||::|:.|.:
Human   976 IGDINIRPNKESWKVFEEMIEPYRLHESCKD---LTTAEKLKRETPWKITDAELEAVKEKSYRQV 1037

  Fly  1146 RLREYLREQSTKSDLVVMTLPMPRKNIVSAPLYMAWLESLSRDMPPFLFVRGNQTSVLTFYS 1207
            ||.|.|:|.|..::|:|::||:.||..:|..|||||||.|::::||.|.||||..:||||||
Human  1038 RLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_2	155..1207	CDD:459263	500/1086 (46%)
SLC12A1	NP_000329.2	RFXV motif. /evidence=ECO:0000269|PubMed:21321328	20..23		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..53		7/54 (13%)
		2a30	104..1099	CDD:273347	500/1087 (46%)