Protein Alignment Ncc69 and slc12a10.1

DIOPT Version :10

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: XP_073763114.1
• Gene: slc12a10.1 / 570849
• ZFINID: ZDB-GENE-060503-330
• Length: 1048
• Species: Danio rerio
• Alignment Length: 1210
• Identity: 451/1210 - (37%)
• Similarity: 663/1210 - (54%)
• Gaps: 227/1210 - (18%)

  Fly    37 GPGSGSGAGAGAGAGAGEDGPHEVYRRLTNAEGELLEDD--TFDATQMLNQRQPRQQRQSIKSSF 99
            |..|.....:|..:|:.|..||  |...:|.....:..|  |..::::||.||
Zfish     9 GLSSTDNLPSGQFSGSEEAPPH--YSSYSNGIDTAITVDSPTRRSSEVLNSRQ------------ 59

  Fly   100 RDKDKPSRFKDLQTTTRFQVDPQNEESDESNDSQEERELLDNEYDTKYGKSFRHFTREALPRLDN 164
             |..:||.:.                                             |.:|:|.|:.
Zfish    60 -DSRRPSIYS---------------------------------------------TIDAMPHLEF 78

  Fly   165 YRNMMS---IQAAYRPTLDELHNATLVGK-----------NTHSL--TRNQDPESGIL---NGVL 210
            |.|..:   |:.: ||:|:.|......|:           :..:|  |.|:..|:|..   :..:
Zfish    79 YANATTTGRIRRS-RPSLETLRKVCDNGECGVNSGDSCAGSIAALQETENKSEENGETAKKSEPV 142

  Fly   211 KFGWIKGVLVRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIK 275
            :|||:.||::||:||||||:|||||||:..|||::..:::||.:..||:|||||:|||||||.:.
Zfish   143 RFGWVTGVMIRCMLNIWGVILFLRLSWITSQAGILLTWLIILMSVLVTSITALSVSAISTNGRVS 207

  Fly   276 GGGTYYMISRSLGPEFGGSIGLIFSLANAVACAMYVVGFCESMLAMMTTFGWEIIDGGVQDVRII 340
            .||.|:||||:||||.||.||::||.|||:|||:..|||.|::..::.....:|:| .|.|||||
Zfish   208 SGGAYFMISRTLGPELGGPIGVVFSFANALACALNTVGFSETVRDLLIENNSQIVD-SVNDVRII 271

  Fly   341 GCITILLLLIIVVVGMEWEAKAQIGLLIILLVAIGDFVIGSFIGPKSDAEMAKGFLGYNATLFKN 405
            |.||:..||:|.:.|||||:|.||...::|:|:..::.:||.| |.:..:.:.||..|.:.:|..
Zfish   272 GSITVTALLLISLAGMEWESKTQILFFLVLMVSFTNYFVGSVI-PATPQKQSIGFFSYRSEIFVE 335

  Fly   406 NLFADYRPEKGGIQHDFFSVFAIFFPAATGILAGANISGDLKDPQKSIPKGTILAIVITTGTYLI 470
            |||.|:|...|    |||.:||||||:|.|||||||||||||:|:.:||:||::||..||.:||.
Zfish   336 NLFPDWRGPDG----DFFRMFAIFFPSAIGILAGANISGDLKEPEIAIPRGTLMAIFCTTISYLA 396

  Fly   471 MVLQCGATVARDATGNLSDVVNGTFA-------------FLDC-QPGECNYGLQNSFQVIELVSA 521
            :....||.|.|||:||::|.:...|.             |.:| |.|.|:|||.|||||:..||.
Zfish   397 ISSTVGACVLRDASGNMNDSLPLNFTEACDSLSCSLGWNFTECEQSGSCSYGLSNSFQVLVQVSG 461

  Fly   522 FGPLIYAGCYAATLSSALASLVSAPKVFQALCKDELYPKIVWFAKGYGKNNEPVRGYVLTFIIAC 586
            ||||||||.:|||||||||.||||||:||.||:|.:||.|.:|.||||||:||:|.|:|.:|||.
Zfish   462 FGPLIYAGIFAATLSSALAFLVSAPKIFQCLCRDNIYPYIGFFGKGYGKNSEPLRAYLLCYIIAM 526

  Fly   587 AFILIGELNLIAPLISNFFLAAYMLINFSTFHASLAKPVGWRPTFKYYNMWLSLLGAILCVAVMF 651
            .||||.|||.||||||||||.:|.|||||.||||:....||||:|:||:.|..|.||.:.|.:||
Zfish   527 CFILIAELNTIAPLISNFFLCSYALINFSCFHASITNSPGWRPSFRYYSPWTGLFGAAISVVLMF 591

  Fly   652 LISWATALITFAAVLALYLIVAYRKPDVNWGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQILV 716
            |::|..|||:.|.::.|:..|||:||:|||||:.||.||..||.....|..||:||||||||.||
Zfish   592 LLTWWAALISLALIIFLFGYVAYKKPEVNWGSSVQASTYNMALSYSVSLAGVEDHVKNYRPQCLV 656

  Fly   717 LSGLPNTRPVLVDLAYMLTKNLSLLVCGHVLKGSSSQKYRTYLQERAGN----WFRKHRVKGFYA 777
            |:|.|..||.|||.....|||:||::||.::    .:..::.:.|...|    |..:.:|:.||.
Zfish   657 LTGPPTLRPALVDFVGSFTKNVSLMICGDII----MEDEKSIMSECNTNEMLKWLNQRKVRSFYT 717

  Fly   778 LVDGEDFESGTRALMQATGIGKLKPNIILMGYKTDWQTCDHKELDQYFNVMHKALDMYLSVAILR 842
            .........|.|.|:||:|:|||:|||::||:|.:||..:.::::.|.|.::.:.|....|.:||
Zfish   718 AFRSSSLREGARHLLQASGLGKLRPNILVMGFKMNWQESNSQDIEDYINTIYDSFDSNHGVCVLR 782

  Fly   843 VPQGLDCSQVLGSQDGWKTVSDVPRTLQPNESSGDLQAVDSSVRNGLSGSIDSLSRNVSQEDRNR 907
            :..|||....|        .::|....:|:|
Zfish   783 MMDGLDIRDEL--------QTEVNPVFEPDE---------------------------------- 805

  Fly   908 NQLVHSEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGNQSKDVSGMPDPLDAKSANLVS 972
             .:...:|||                      .|.||:.                   .:.|:.:
Zfish   806 -PIEFDQQNS----------------------DSDSDVD-------------------NTKNIAN 828

  Fly   973 NSLRKSKLKHDDPASLYKGPGGAELPKEVLADLTQFTRKRSHAVIDVWWLYDDGGLTLLLPYIIS 1037
            :.::                             |.|..|:....|||:|:.||||||||:||:::
Zfish   829 DQIK-----------------------------TVFQTKQGKKTIDVYWISDDGGLTLLVPYLLT 864

  Fly  1038 TRRTWQSCKLRVYALANKNSELEFEQRSMASLLSKFRIDYSDLTLIPDITKKPQETSTQFFNELI 1102
            .|:.|:..|:||: :..:...:|.|::.|.:||.:||:|..|:.::.|..::|...:.|.|.:.:
Zfish   865 RRKRWRRSKVRVF-IVGEQKTMEDERKEMKTLLQRFRLDVHDVIVMTDSKRQPLAKNMQRFEDTV 928

  Fly  1103 KDFVVTEKDGENGTSSRATLNEDDALITDDDLLAVQDKTNRYLRLREYLREQSTKSDLVVMTLPM 1167
            ..|.:.:...:..|..:..: |:...:||..:.|::.|:.|.:||.|.:|..|..:.||:::||:
Zfish   929 APFRLNDAQLDERTVQQQRM-ENPWKVTDKQMDALRLKSERKVRLNEIIRRNSQHAALVLVSLPV 992

  Fly  1168 PRKNIVSAPLYMAWLESLSRDMP-PFLFVRGNQTSVLTFY 1206
            |:.:..|: ||||||::||..:. |.|.:||||.:|:|||
Zfish   993 PQADCPSS-LYMAWLDTLSCGLHCPVLLIRGNQQNVMTFY 1031

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_2	155..1207	CDD:459263	433/1090 (40%)
slc12a10.1	XP_073763114.1	None