DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ncc69 and SLC12A9

DIOPT Version :9

Sequence 1:	NP_001261758.1	Gene:	Ncc69 / 39410	FlyBaseID:	FBgn0036279	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_001350422.1	Gene:	SLC12A9 / 56996	HGNCID:	17435	Length:	914	Species:	Homo sapiens

Alignment Length:	1057	Identity:	264/1057 - (24%)
Similarity:	439/1057 - (41%)	Gaps:	257/1057 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 KFGWIKGVLVRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIK 275
            |.....||:|..:|:::.:::|||:.:|||.||:::...::|....:..:|.||:.||:|||.::
Human    36 KLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIATNGAVQ 100

  Fly   276 GGGTYYMISRSLGPEFGGSIGLIFSLANAVACAMYVVGFCESML--------------AMMTTFG 326
            |||.|:||||:||||.||||||:|.|||...||:.::|..||:|              .:...:|
Human   101 GGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDVFGADATGPSGLRVLPQGYG 165

  Fly   327 WEIIDGGVQDVRIIGCITIL---------LLLIIVVVGMEWEAKAQIGLLIILLVAIGDFVI--- 379
            |.::.|.:. :.::|.:..|         .|..::|.|       .:..::|..||:|...|
Human   166 WNLLYGSLL-LGLVGGVCTLGAGLYARASFLTFLLVSG-------SLASVLISFVAVGPRDIRLT 222

  Fly   380 ------GSFIGPKSDAEMAKGFLGYNATLFKNNLFADYRPE-KGGIQHDFFSVFAIFFPAATGIL 437
                  ||.:.|:..     .|.|:|::..|:||.|.|..: ..|...:|.||||:.|...|||:
Human   223 PRPGPNGSSLPPRFG-----HFTGFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIM 282

  Fly   438 AGANISGDLKDPQKSIPKGTILAIVITTGTYLIMVLQCGATVARDATGNLSDVVNGTFAFLDCQP 502
            ||||:||:||||.::||.|||:|:..|...|:::......|..|..
Human   283 AGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTL------------------- 328

  Fly   503 GECNYGLQNSFQVIELVSAFGPLIYAGCYAATLSSALASLVSAPKVFQALCKDELYPKIVWFAKG 567
                  ||..:.....:|.:.||:..|.||..||::::||:.|.::..||.:|:|:..|:..||.
Human   329 ------LQEDYGFFRAISLWPPLVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAKV 387

  Fly   568 YGKNNEPVRGYVLTFIIACAFILIGELNLIAPLISNFFLAAYMLINFSTFHASLAKPVGWRPTFK 632
            ..:...|....:.::.:....:|.|:||.:|.:::.|:|.||..::.|......|....:||||.
Human   388 VSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFS 452

  Fly   633 YYNMWLSLLGAILCVAVMFLISWATA---LITFAAVLALYLIVAYRKPDVNWGSTTQAQTYKNAL 694
            .::....|||...|:.:|||||...|   |:....:.|  |:.|...|. :||..:||..:....
Human   453 LFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAA--LLTARGGPS-SWGYVSQALLFHQVR 514

  Fly   695 MSVQQLNNVEEHVKNYRPQILVLSGLPNTRPVLVDLAYMLTKNLSLLVCGHVLKGSSSQKYRTYL 759
            ..:.:|:..::|||.:|||:|:|.|.|.....|:.||..|.|. .|.|.|||..|.........:
Human   515 KYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQLKKG-GLYVLGHVTLGDLDSLPSDPV 578

  Fly   760 QERAGNWFR---KHRVKGFYALVDGEDFESGTRALMQATGIGKLKPNIILMGYKTDWQTCDHKEL 821
            |.:.|.|..   :.:||.|..|........|.:.|::.:|:|.:|||.:::|:..|....||...
Human   579 QPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLT 643

  Fly   822 DQYFNVMHKALDMYLSVAILRVPQGLDCSQVLGSQDGWKTVSDVPRTLQPNESSGDLQAVDSSVR 886
            |..|:                  :..|.::. ||.....|:...||.
Human   644 DPAFS------------------EPADSTRE-GSSPALSTLFPPPRA------------------ 671

  Fly   887 NGLSGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGN 951
                                                             ||:..:.:...::|
Human   672 -------------------------------------------------PGSPRALNPQDYVA-- 685

  Fly   952 QSKDVSGMPDPLDAKSANLVSNSLRKSKLKHDDPASLYKGPGGAELPKEVLADLTQFTRKRSHAV 1016
                              .|:::|:.:|       ::........||.|.|:..:..|.:..|
Human   686 ------------------TVADALKMNK-------NVVLARASGALPPERLSRGSGGTSQLHH-- 723

  Fly  1017 IDVWWL-----------YDDGGLTLL-LPYIISTRRTWQSCKLRVYALANKNSELEFEQRSMASL 1069
            :|||.|           .|..||.|| :..|:.....|.|.:||::............:..:.:|
Human   724 VDVWPLNLLRPRGGPGYVDVCGLFLLQMATILGMVPAWHSARLRIFLCLGPREAPGAAEGRLRAL 788

  Fly  1070 LSKFRIDYSDLTLIPDI-------TKKPQETSTQFFNELIKDFVVTEKDGENGTSSRATLNEDDA 1127
            ||:.||...    :.::       ..:|:                .|::|:...|.|.
Human   789 LSQLRIRAE----VQEVVWGEGAGAGEPE----------------AEEEGDFVNSGRG------- 826

  Fly  1128 LITDDDLLAVQDKTNRYLRLR------------EYLREQSTKSDLVVMTLPMPRKNIVSAPLYMA 1180
               |.:..|:....|..:|.:            |....:...:.|..:.||.|..:....|.|:|
Human   827 ---DAEAEALARSANALVRAQQGRGTGGGPGGPEGGDAEGPITALTFLYLPRPPADPARYPRYLA 888

  Fly  1181 WLESLSRDMPPFLFVRG 1197
            .||:|:||:.|.|.|.|
Human   889 LLETLTRDLGPTLLVHG 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588
		2a30	155..1207	CDD:273347	264/1057 (25%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	48/160 (30%)
		SLC12	724..1207	CDD:281515	94/508 (19%)
SLC12A9	NP_001350422.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	844..863		1/18 (6%)
		SLC12	36..905	CDD:332077	263/1055 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	642..678		10/121 (8%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910