Protein Alignment Ncc69 and slc12a7b

DIOPT Version :9

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: XP_005162967.1
• Gene: slc12a7b / 567667
• ZFINID: ZDB-GENE-030829-61
• Length: 1138
• Species: Danio rerio
• Alignment Length: 1365
• Identity: 326/1365 - (23%)
• Similarity: 521/1365 - (38%)
• Gaps: 457/1365 - (33%)

  Fly    64 LTNAEGELLEDDT-----FDATQMLNQRQPRQQRQSIKSSFRDKDKPSRFKDLQTTTRFQVDPQN 123
            :.:||.....|:|     |||.:     ..|.:::......|...:|:::.|        .:|:
Zfish    10 VAHAEESAFGDETDGAPVFDAGE-----DARAEQRGSLPILRYNREPNKYGD--------GNPR- 60

  Fly   124 EESDESNDSQEERELLDNEYDTKYGKSFRHFTRE---------ALPRLDNYRNMMSIQAAYRPTL 179
            |.|...|::.:::   .|.||   ||:...|..|         .|.:|.||.|:..
Zfish    61 ESSPFINNTDDDK---GNLYD---GKNMALFEEEMDSNPMVSSLLNKLANYTNLTQ--------- 110

  Fly   180 DELHNATLVGKNTHSLTRNQDPESGILNGVLK---FGWIKGVLVRCLLNIWGVMLFLRLSWVVGQ 241
                     |...|   ...|.:.|.....:|   .|...||.:.||.||.||:||||::|:||.
Zfish   111 ---------GVREH---EEADEDEGAKKQTVKSPQMGTFIGVYLPCLQNILGVILFLRMTWIVGT 163

  Fly   242 AGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMISRSLGPEFGGSIGLIFSLANAVA 306
            ||::|.|:::....:.|.:||:|||||:||||:..||:||||||||||||||::||.|.|....|
Zfish   164 AGILEAFIIVSMCCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFA 228

  Fly   307 CAMYVVGFCESMLAMMTTFG--------WEIIDGGVQDVRIIGCITILLLLIIVVVGMEWEAKAQ 363
            .|||::|..|.:|..:....        .:..:..:.::|:.|...:.|:.::|.||:::..|..
Zfish   229 GAMYILGTIEILLTYIVPSAAIFKAEDKADEAEALLNNMRVYGTCCLTLMALVVFVGVKYVNKLA 293

  Fly   364 IGLL---IILLVAIGDFVIGSFI------------------------------------------ 383
            :..|   ::.::||...||.:..
Zfish   294 LVFLACVVLSILAIYAGVIKTIFEPPVFPVCVLGNRTLQNHDFDKCMKTEIIDNVTVTTKLWSLF 358

  Fly   384 --GPKSDAEM-----------AKGFLGYNATLFKNNLFADYRPEKGGIQHDFFSVFA-------- 427
              ||:.:|..           .:|..|..:.:...|::..|.|....::.|..||.|
Zfish   359 CSGPELNASCNEYFTLNSVTEIQGIPGLTSGVISENMWGKYGPAGMLVEKDIPSVSASDSSQDKY 423

  Fly   428 -----------------IFFPAATGILAGANISGDLKDPQKSIPKGTILAIVITTGTYLIMVLQC 475
                             |:||:.|||:||:|.||||:|.|:|||.||||||..||..||..|:..
Zfish   424 MPYVVNDITAFFTLLVGIYFPSVTGIMAGSNRSGDLRDAQRSIPIGTILAIATTTIIYLSCVVLF 488

  Fly   476 GA----TVARDATGNLSDVVNGTFAFLDCQPGECNYGLQNSFQVIELVSAFGP-LIYAGCYAATL 535
            ||    .|.||..|   |.|.|..                   ||..:|...| :|..|.:.:..
Zfish   489 GACIEGVVLRDKFG---DSVKGNL-------------------VIGTLSWPSPWVIVIGSFFSCC 531

  Fly   536 SSALASLVSAPKVFQALCKDELYPKIVWFAKGYGK-NNEPVRGYVLTFIIACAFILIGELNLIAP 599
            .:.|.||..||::.||:.:|.:.|.:..|  |:|| |.||....:||.:|..:.|||..|:.:||
Zfish   532 GAGLQSLTGAPRLLQAIARDGIVPFLEVF--GHGKANGEPTWALLLTALICESGILIASLDAVAP 594

  Fly   600 LISNFFLAAYMLINFSTFHASLAKPVGWRPTFKYYNMWLSLLGAILCVAVMFLISWATALITFAA 664
            ::|.|||..|:.:|.:....:|.:...|||.||||:..||.||..||:|:||:.||..||:....
Zfish   595 ILSMFFLMCYLFVNLACALQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFISSWYYALVAMLI 659

  Fly   665 VLALYLIVAYRKPDVNWGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQILVLSGLPN----TRP 725
            ...:|..:.||..:..||...:..:...|..::.:|.....|.||:|||:|||..|.:    ..|
Zfish   660 AGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALIRLEEAPPHTKNWRPQMLVLLNLDSELCVKHP 724

  Fly   726 VLVDLAYMLTKNLSLLVCGHVLKGS--SSQKYRTYLQERAGNWFRKHRVKGFYALVDGEDFESGT 788
            .|:.....|.....|.:.|.||:|:  |.:......::...:.....:.|||..:|...:...|.
Zfish   725 RLLSFTTQLKAGKGLTIVGSVLEGTYLSRENQAKRAEQNIKSAMAAEKTKGFCHVVVSSNLRDGI 789

  Fly   789 RALMQATGIGKLKPNIILMGYKTDW-QTCDHKELDQYFNVMHKALDMYLSVAILRVPQGLDCSQV 852
            ..|:|:.|:|.:|.|.:||.:.::| |:.|......:...:.:....:|::.:.:
Zfish   790 SHLVQSAGLGGMKHNSVLMAWPSNWRQSSDPHTWRSFIETVRETTAAHLALLVAK---------- 844

  Fly   853 LGSQDGWKTVSDVPRTLQPNESSGDLQAVDSSVRNGLSGSIDSLSRNVSQEDRNRNQLVHSEQNS 917
                                                   ::||..              |.|:
Zfish   845 ---------------------------------------NVDSFP--------------HQER-- 854

  Fly   918 LKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGNQSKDVSGMPDPLDAKSANLVSNSLRKSKLKH 982
                                                                             
Zfish   855 ----------------------------------------------------------------- 854

  Fly   983 DDPASLYKGPGGAELPKEVLADLTQFTRKRSHAVIDVWWLYDDGGLTLLLPYIISTRRTWQSCKL 1047
                                  ||:.|       |||||:..|||:.:|||:::...:.|:.||:
Zfish   855 ----------------------LTEGT-------IDVWWIVHDGGMLMLLPFLLRQHKVWKKCKM 890

  Fly  1048 RVYALANK--------------------NSELE-------------------FEQRSMASLLSKF 1073
            |::.:|..                    |:|:|                   .||||  .:|.:.
Zfish   891 RIFTVAQMDDNSIQMKKDLQMFLYHLRLNAEVEVVEMHDSDISAFTYEKTLVMEQRS--QMLKQM 953

  Fly  1074 RIDYS----DLTLIPD-----ITKKPQ----ETSTQFFN---------ELIKDFVVTEKDGENGT 1116
            ::..:    ::..|.|     |.:|.|    .:|.|..|         :||.|         ..|
Zfish   954 QLSRTEREREIQSITDESRSSIRRKNQSEAHSSSLQNQNTAHEQQDEAQLIHD---------RNT 1009

  Fly  1117 SSRATLNEDDALITDDDL----------------------LAVQDKTN----------------- 1142
            :|...:| |.|..|.:.:                      :||:|..|
Zfish  1010 ASHTAMN-DKADATPERVHMTWTKEKLFSERSRRTEANASMAVRDLFNMKPEWESLNQSNVRCMH 1073

  Fly  1143 RYLRLREYLREQSTKSDLVVMTLPMPRKNIVSAPLYMAWLESLSRDMPPFLFVRGNQTSVLTFYS 1207
            ..::|.|.:..:|..:.||::.:|.|.||......||.::|.:...:...|.|||....|:|.||
Zfish  1074 TAVKLNEVIVNKSQGAHLVLLNMPGPPKNRGGDENYMEFMEVMMEGLNRVLLVRGGGREVITIYS 1138

  Fly  1208  1207
            Zfish  1139  1138

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588	10/47 (21%)
		2a30	155..1207	CDD:273347	303/1267 (24%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	58/159 (36%)
		SLC12	724..1207	CDD:281515	96/585 (16%)
slc12a7b	XP_005162967.1	2a30	58..1138	CDD:273347	313/1302 (24%)
		SLC5-6-like_sbd	182..>319	CDD:294310	50/136 (37%)
		SLC12	724..978	CDD:281515	60/414 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594120
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850