Protein Alignment Ncc69 and slc12a3

DIOPT Version :9

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: NP_001038545.1
• Gene: slc12a3 / 565439
• ZFINID: ZDB-GENE-030131-9505
• Length: 1012
• Species: Danio rerio
• Alignment Length: 1118
• Identity: 444/1118 - (39%)
• Similarity: 634/1118 - (56%)
• Gaps: 188/1118 - (16%)

  Fly   141 NEYDT------KYGKSFRHFTREALPRLDNYRNMMSIQAA--YRPTLDELHN------------- 184
            :.|||      ..|....:.|.:|.|..|.|.|......|  .||:|.|||:
Zfish    29 SSYDTDSVASRSSGVFSGYDTLDAPPSYDFYTNTEVFGRAKKSRPSLFELHSNPQDDPSPPPLYE 93

  Fly   185 ATLVGKNTHSLTRNQD------PESGILNGVLKFGWIKGVLVRCLLNIWGVMLFLRLSWVVGQAG 243
            .:.|.|.:   ..::|      ||..      :|||.:||::||:||||||:|:|||.|:..|||
Zfish    94 ESSVDKQS---PEDEDEPTEPPPEPA------RFGWAQGVMIRCMLNIWGVILYLRLPWITAQAG 149

  Fly   244 VIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMISRSLGPEFGGSIGLIFSLANAVACA 308
            :...:::||.::::|.||.||.|||:|||.:||||||::||||||||.||||||||:.|||||.|
Zfish   150 IGLTWIIILVSSSITGITGLSTSAIATNGKVKGGGTYFLISRSLGPELGGSIGLIFAFANAVAVA 214

  Fly   309 MYVVGFCESMLAMMTTFGWEIIDGGVQDVRIIGCITILLLLIIVVVGMEWEAKAQIGLLIILLVA 373
            |:.|||.|::..:|......::| .:.|:||||.||:..||.|.:.|||||:|||:....:::::
Zfish   215 MHTVGFAETVQVLMQETEVSMVD-KLNDIRIIGVITVTCLLAISMAGMEWESKAQVLFFFVIMIS 278

  Fly   374 IGDFVIGSFIGPKSDAEMAKGFLGYNATLFKNNLFADYRPEKGGIQHDFFSVFAIFFPAATGILA 438
            ...::||:.| |.:..:.|:||..|.|.:|..|....:|..:|    .||.:|:||||:||||||
Zfish   279 FASYIIGTII-PATPQKQARGFFSYRADIFATNFVPGWRGPEG----SFFGMFSIFFPSATGILA 338

  Fly   439 GANISGDLKDPQKSIPKGTILAIVITTGTYLIMVLQCGATVARDATGNLSDVV------------ 491
            |||||||||||..:||:||:|||..||.:|||:....|:.|.|||:|:::|.:
Zfish   339 GANISGDLKDPNVAIPRGTMLAIFWTTVSYLIISATIGSCVVRDASGDVNDTISSLTGECLGVGC 403

  Fly   492 NGTFAFLDCQPGE-CNYGLQNSFQVIELVSAFGPLIYAGCYAATLSSALASLVSAPKVFQALCKD 555
            |..:.|.||.... |.|||.|.:|.:.:|||..|||.||.:.||||||||.|||||||||.||||
Zfish   404 NYGWNFTDCMTNNTCTYGLSNYYQSMSMVSAVAPLITAGIFGATLSSALACLVSAPKVFQCLCKD 468

  Fly   556 ELYPKIVWFAKGYGKNNEPVRGYVLTFIIACAFILIGELNLIAPLISNFFLAAYMLINFSTFHAS 620
            :|||.|.:|.|||||||||:|.|:|.:|||..||||.|||.|||:||||||.:|.|||||.||||
Zfish   469 KLYPGIGFFGKGYGKNNEPLRSYLLAYIIAICFILIAELNTIAPIISNFFLCSYALINFSCFHAS 533

  Fly   621 LAKPVGWRPTFKYYNMWLSLLGAILCVAVMFLISWATALITFAAVLALYLIVAYRKPDVNWGSTT 685
            :....||||||::|:.|||||||::.|.:|||::|..|||....|:.|...|.|:||:|||||:.
Zfish   534 ITNSPGWRPTFRFYSKWLSLLGAVVSVIIMFLLTWWAALIAIGIVIFLLGYVLYKKPEVNWGSSM 598

  Fly   686 QAQTYKNALMSVQQLNNVEEHVKNYRPQILVLSGLPNTRPVLVDLAYMLTKNLSLLVCGHVL--- 747
            ||.:|..||.....||.||:|:||||||.|||||.|..||.|||.....|||.||::|.:||
Zfish   599 QASSYNMALSQCVGLNQVEDHIKNYRPQCLVLSGPPCARPSLVDFIGAFTKNQSLMICANVLASG 663

  Fly   748 --KGSSSQKYRTYLQERAGNWFRKHRVKGFYALVDGEDFESGTRALMQATGIGKLKPNIILMGYK 810
              .|::.....|:|:     |....::|.||..|..:|..:|.:.|:|:||:|::|||:::||||
Zfish   664 PSPGTADSMSSTHLK-----WLNNRKIKSFYHTVVADDLRTGVQMLLQSTGLGRMKPNVLVMGYK 723

  Fly   811 TDWQTCDHKELDQYFNVMHKALDMYLSVAILRVPQGLDCSQVLGSQDGWKTVSDVPRTLQPNESS 875
            .:|:......::.|..::|.|.|:...|.:||:.:||                |:.||:|...:.
Zfish   724 KNWRKVQPGIIENYVGILHDAFDLQYGVCVLRMKEGL----------------DITRTIQAQVNL 772

  Fly   876 GDLQAVDSSVRNGLSGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPGAAS 940
            |    .::|...|
Zfish   773 G----FETSTEQG---------------------------------------------------- 781

  Fly   941 STSDLSFIAGNQSKDVSGMPDPLDAKSANLVSNSLRKSKLKHDDPASLYKGPGGAELPKEVLADL 1005
                                  ||..|....|.::.                  |.|..|.|..|
Zfish   782 ----------------------LDTNSTAPTSPTIE------------------ASLDPETLMAL 806

  Fly  1006 TQ----FTRKRSHAVIDVWWLYDDGGLTLLLPYIISTRRTWQSCKLRVYALANKNSELEFEQRSM 1066
            ||    |..::....|||:||.||||||||:||:::.::.|..||:||: :..:..::|.:::.:
Zfish   807 TQPSTLFQTRQGKKTIDVYWLSDDGGLTLLIPYLLTRKKRWGRCKVRVF-VGGEAQQIEEQKKEL 870

  Fly  1067 ASLLSKFRIDYSDLTLIPDITKKPQETSTQFFNELIKDFVVT--EKDGENGTSSRATLNEDDALI 1129
            ..|:|:||:.:.|:.::|||...||....:.|.:.|..:.|:  :|||:.  :..|| .|...::
Zfish   871 KGLISRFRLGFKDIQVLPDINGAPQSEHIRKFEDFIAPYRVSSVQKDGQE--ADEAT-KEFSWMV 932

  Fly  1130 TDDDLLAVQDKTNRYLRLREYLREQSTKSDLVVMTLPMPRKNIVSAPLYMAWLESLSRDM-PPFL 1193
            :|:::...:.|:.|.:||.|.:::.|..:.|:|:|:|:.|:....:||||||||.:|||: ||.|
Zfish   933 SDEEMETFKAKSLRQIRLNEVIQDYSRDAALIVVTMPVGRRGSCPSPLYMAWLEIVSRDLRPPVL 997

  Fly  1194 FVRGNQTSVLTFY 1206
            .|||||.:|||.|
Zfish   998 LVRGNQENVLTQY 1010

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588	14/46 (30%)
		2a30	155..1207	CDD:273347	440/1098 (40%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	102/157 (65%)
		SLC12	724..1207	CDD:281515	139/495 (28%)
slc12a3	NP_001038545.1	AA_permease_N	34..101	CDD:285588	16/66 (24%)
		2a30	48..1011	CDD:273347	440/1099 (40%)
		GtrA	<490..589	CDD:303012	57/98 (58%)
		SLC12	637..1011	CDD:281515	139/495 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594116
Domainoid	1	1.000	592	1.000	Domainoid score	I198
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	817	1.000	Inparanoid score	I458
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D135130at33208
OrthoFinder	1	1.000	-	-		FOG0001536
OrthoInspector	1	1.000	-	-		mtm6412
orthoMCL	1	0.900	-	-		OOG6_101360
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5652
SonicParanoid	1	1.000	-	-		X709
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.900