DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ncc69 and slc12a10.2

DIOPT Version :9

Sequence 1:	NP_001261758.1	Gene:	Ncc69 / 39410	FlyBaseID:	FBgn0036279	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_001038466.1	Gene:	slc12a10.2 / 562834	ZFINID:	ZDB-GENE-060503-425	Length:	998	Species:	Danio rerio

Alignment Length:	1059	Identity:	430/1059 - (40%)
Similarity:	596/1059 - (56%)	Gaps:	163/1059 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 RPTLDELHNATLVGKNTHSLTRNQDPESGILN-GVLKFGWIKGVLVRCLLNIWGVMLFLRLSWVV 239
            ||:||.|.|.      ...:|...|.|.|... .:::|||:.||.:||:||||||:::|||.||.
Zfish    73 RPSLDVLRNP------PDDITPTPDEEDGRPKVKLVRFGWVLGVWIRCMLNIWGVIMYLRLPWVT 131

  Fly   240 GQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMISRSLGPEFGGSIGLIFSLANA 304
            .|||::..||:|..:..:|||||.|:|||||||.:..||||:|||||||||.|..|||:|:.|.:
Zfish   132 SQAGLVLTFVIIFMSVTITTITATSVSAISTNGKVYSGGTYFMISRSLGPELGAPIGLLFAFACS 196

  Fly   305 VACAMYVVGFCESMLAMMTTFGWEIIDGGVQDVRIIGCITILLLLIIVVVGMEWEAKAQIGLLII 369
            :|||::.|||.|::..|:..|..:::| .|.||||||.||:.:.|:|...||.|||||||...|.
Zfish   197 IACALHTVGFSETVRDMLKDFKSQMVD-DVNDVRIIGAITVTICLLITFAGMAWEAKAQILFFIA 260

  Fly   370 LLVAIGDFVIGSFIGPKSDAEMAKGFLGYNATLFKNNLFADYRPEKGGIQHDFFSVFAIFFPAAT 434
            :::::.::.:|:.|.|..:.| |.||.||::.:|.:||...:|...|    .|..||||||||.|
Zfish   261 IILSLLNYFVGTVIPPTQEKE-AVGFFGYHSDIFVSNLLPSFRGPSG----SFLVVFAIFFPACT 320

  Fly   435 GILAGANISGDLKDPQKSIPKGTILAIVITTGTYLIMVLQCGATVARDATGNLSD---VVNGTF- 495
            |||:|.||.||||||...|||||:|:|:.||.:||::...|.|||.|||:||.:|   :.|.|.
Zfish   321 GILSGVNICGDLKDPTGGIPKGTLLSILCTTLSYLLIAATCAATVVRDASGNKNDSLAISNYTIH 385

  Fly   496 -AFLDCQPG----------ECNYGLQNSFQVIELVSAFGPLIYAGCYAATLSSALASLVSAPKVF 549
             :.|.|:.|          .|..||.|:.:::.:||.:|.||..|.:||||||||..||||||||
Zfish   386 CSGLGCKYGWNFDSCEQYRNCTQGLANNLRILTVVSGWGILITIGTFAATLSSALGFLVSAPKVF 450

  Fly   550 QALCKDELYPKIVWFAKGYGKNNEPVRGYVLTFIIACAFILIGELNLIAPLISNFFLAAYMLINF 614
            |.||||::||.|.:|.||||||.||:|.||||||||..|||||.||.|||||||||||:|.||||
Zfish   451 QLLCKDKIYPYIGFFGKGYGKNKEPLRAYVLTFIIAMCFILIGNLNTIAPLISNFFLASYGLINF 515

  Fly   615 STFHASLAKPVGWRPTFKYYNMWLSLLGAILCVAVMFLISWATALITFAAVLALYLIVAYRKPDV 679
            |.||||:.|..||||.::||:.||||....|...:|||.:|..||:||:.||.|...|.|:|..|
Zfish   516 SCFHASITKSPGWRPQYRYYSPWLSLFCCCLSFTLMFLFTWWAALVTFSVVLFLIGYVNYKKTYV 580

  Fly   680 NWGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQILVLSGLPNTRPVLVDLAYMLTKNLSLLVCG 744
            ||||:.||..|..||.....|..|.:||||:|||.|||||.|||||.|||.....|||:||::||
Zfish   581 NWGSSYQAAFYNMALNFSMNLTTVPDHVKNFRPQCLVLSGPPNTRPALVDFVGTFTKNVSLMICG 645

  Fly   745 HVLKGSSSQKYRTYLQERAGNWFRKHRVKGFYALVDGEDFESGTRALMQATGIGKLKPNIILMGY 809
            ::........:..:..:....|..|.:|:.||.....|..:.|...||.|:|:||||||.:::||
Zfish   646 NITIEGEQSDFPEHSSDLVVEWLTKRKVRSFYTTFAAESLQDGAHNLMLASGLGKLKPNTLVLGY 710

  Fly   810 KTDWQTCDHKELDQYFNVMHKALDMYLSVAILRVPQGLDCS-QVLGSQDGWKTVSDVPRTLQPNE 873
            ||:||.|..:.|..|.|.::.|.|....||:||:...||.: .:..::||
Zfish   711 KTNWQECKPESLQDYINTINDAFDSNYGVALLRMMDKLDITDDMYSAEDG--------------- 760

  Fly   874 SSGDLQAVDS------SVRNGLSGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRM 932
                |.|:|:      .|....|.:||..|.|..:|.
Zfish   761 ----LSAIDNPAFERDEVPQSRSDTIDRDSDNSDEES---------------------------- 793

  Fly   933 RSWPGAASSTSDLSFIAGNQSKDVSGMPDPLDAKSANLVSNSLRKSKLKHDDPASLYKGPGGAEL 997
                                                   |:.:|
Zfish   794 ---------------------------------------SDQIR--------------------- 798

  Fly   998 PKEVLADLTQFTRKRSHAVIDVWWLYDDGGLTLLLPYIISTRRTWQSCKLRVYALANKNSELEFE 1062
                    |.|..|:....||::|:.||||||||:||:::.|..|:..|:||:.|.::.::.| :
Zfish   799 --------TVFQAKQGKKTIDIYWISDDGGLTLLVPYLLTRRNRWKKSKIRVFILGDQETKKE-D 854

  Fly  1063 QRSMASLLSKFRIDYSDLTLIPDITKKPQETSTQFFNELIKDFVVTEKDGENGTSSRATLNEDDA 1127
            :..|..||.:||::..::.:|.|:.|.|...:.|.|.:.|..|.::|:      .:|..|.|...
Zfish   855 RDDMKMLLKRFRLEIEEVIVITDVDKPPLAKNVQRFEDTITPFRLSEE------QTRVDLQEFRR 913

  Fly  1128 L----ITDDDLLAVQDKTNRYLRLREYLREQSTKSDLVVMTLPMPRKNIVSAPLYMAWLESLSRD 1188
            |    ::|.||.||:.|..|.:||.|.:::.|..:.|||::||:|..|..|: |||||:::||..
Zfish   914 LNPWAVSDKDLEAVRPKVERTVRLNEIIKKNSLYAALVVVSLPVPDLNCPSS-LYMAWMDALSIG 977

  Fly  1189 MP-PFLFVRGNQTSVLTFY 1206
            :. |.|.:||||.:|:|||
Zfish   978 INCPALLIRGNQENVMTFY 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588	4/6 (67%)
		2a30	155..1207	CDD:273347	430/1059 (41%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	101/157 (64%)
		SLC12	724..1207	CDD:281515	138/495 (28%)
slc12a10.2	NP_001038466.1	AA_permease_N	48..98	CDD:285588	10/30 (33%)
		2a30	49..997	CDD:273347	430/1059 (41%)
		SLC5-6-like_sbd	125..556	CDD:294310	231/436 (53%)
		SLC12	625..997	CDD:281515	138/495 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594118
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	817	1.000	Inparanoid score	I458
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D135130at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6412
orthoMCL	1	0.900	-	-		OOG6_101360
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X709
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.770