Protein Alignment Ncc69 and slc12a4

DIOPT Version :10

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: XP_691291.2
• Gene: slc12a4 / 562826
• ZFINID: ZDB-GENE-090218-27
• Length: 1095
• Species: Danio rerio
• Alignment Length: 1286
• Identity: 335/1286 - (26%)
• Similarity: 524/1286 - (40%)
• Gaps: 389/1286 - (30%)

  Fly   117 FQVDPQNEESDESNDSQE------ERELLDNEY----DT---------KYGKSFRHFTREALPRL 162
            |.|.|..:.|..:.||.|      .|:....||    ||         |....|...:..|..|.
Zfish     4 FTVVPVQDNSPSNYDSLEGINWVDYRDTGQGEYPGHGDTVSSDGHGNHKEDSPFLSSSDSASKRN 68

  Fly   163 DNY-RNM------MSIQAAYRPTLDELHNATLV--GKNTH------SLTRNQDPESGILNGVLKF 212
            |.| ||:      :.|:......|..|.|.|.|  |...|      ..:|.|.|:|.      ..
Zfish    69 DFYDRNLALFEEELDIRPKVSSLLSRLVNYTNVTQGAKEHEEAESADASRRQAPKSP------NM 127

  Fly   213 GWIKGVLVRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGG 277
            |.:.||.:.||.||:||:|||||:|:||.|||::.|:::|...:.|.:||:|||||:||||:..|
Zfish   128 GTLMGVYLPCLQNIFGVILFLRLTWIVGTAGVVQSFLIVLMCCSCTMLTAISMSAIATNGVVPAG 192

  Fly   278 GTYYMISRSLGPEFGGSIGLIFSLANAVACAMYVVG----FCESMLAMMTTFGWEIIDGG----V 334
            |.|:||||||||||||::||.|.|....|.|||::|    |.:.::.....|....|..|    :
Zfish   193 GAYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLKYLIPQAAIFHPADIHAGNGAML 257

  Fly   335 QDVRIIGCITILLLLIIVVVGMEWEAKAQ---IGLLIILLVAIGDFVIGSFIGP----------- 385
            .::|:.|.|.:.|:.::|.||:::..|..   :..:||.:|:|....:.|...|
Zfish   258 NNMRVYGTICLSLMAVVVFVGVKYVNKLASLFLACVIISIVSIYAGAVKSIFHPPEFPICMLGNR 322

  Fly   386 ---------------------------------------------KSDAEMAKGFLGYNATLFKN 405
                                                         .::....||..|..:.:.|.
Zfish   323 TLVRDLFDVCGKTVVVGNETVPSKLWKNFCTSDNISSAHCDEYFFHNNVTEIKGIPGLASGIIKE 387

  Fly   406 NLFADYRPEKG--------------------------GIQHDFFSVFAIFFPAATGILAGANISG 444
            |::.||. |||                          .|...|..:..||||:||||:||:|.||
Zfish   388 NMWGDYM-EKGQILEKAKLPSVDVHGSMETFGFYVSADIATSFTLLVGIFFPSATGIMAGSNRSG 451

  Fly   445 DLKDPQKSIPKGTILAIVITTGTYLIMVLQCGA----TVARDATGNL--SDVVNGTFAFLDCQPG 503
            ||:|.|||||.||||||..|:..|...|:..||    .|.||..|:.  .::|.||.::
Zfish   452 DLRDAQKSIPIGTILAITTTSLVYFSSVVLFGACIEGVVLRDKFGDAVSKNLVVGTLSW------ 510

  Fly   504 ECNYGLQNSFQVIELVSAFGP---LIYAGCYAATLSSALASLVSAPKVFQALCKDELYPKIVWFA 565
                                |   :|..|.:.:|:.:.|.||..||::.||:.||.:.|.:..|
Zfish   511 --------------------PSPWVIVIGSFFSTVGAGLQSLTGAPRLLQAIAKDNIIPFLRVF- 554

  Fly   566 KGYGK-NNEPVRGYVLTFIIACAFILIGELNLIAPLISNFFLAAYMLINFSTFHASLAKPVGWRP 629
             |:|| |.||....:||.:||...|||..|:::||::|.|||..|:.:|.:....:|.:...|||
Zfish   555 -GHGKANGEPTWALLLTGLIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRP 618

  Fly   630 TFKYYNMWLSLLGAILCVAVMFLISWATALITFAAVLALYLIVAYRKPDVNWGSTTQAQTYKNAL 694
            .|:||:..||.||..:|:|:||:.||..|::.......:|..:.|:..:..||...:..:...|.
Zfish   619 RFRYYHWALSFLGMSMCLALMFISSWYYAIVAMGIAGMIYKYIEYQGAEKEWGDGIRGLSLSAAR 683

  Fly   695 MSVQQLNNVEEHVKNYRPQILVLSGLPN----TRPVLVDLAYMLTKNLSLLVCGHVLKGSSSQKY 755
            .|:.:|.....|.||:|||:|||..|..    ..|.|:..|..|.....|.:.|.|::|:..:.|
Zfish   684 YSLLRLEAGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGNFLECY 748

  Fly   756 -RTYLQERA-GNWFRKHRVKGFYALVDGEDFESGTRALMQATGIGKLKPNIILMGYKTDWQTCDH 818
             .|...|:| .|.....|||||..:|.......|...|:|:.|:|.:|.|.::||:...|:.
Zfish   749 GETQASEQAIKNMMEIERVKGFCQVVVASKVREGIAHLIQSCGLGGMKHNTVVMGWPYGWRQ--- 810

  Fly   819 KELDQYFNVMHKALDMYLSVAILRVPQGLDCSQVLGSQD--GWKTVSDVPRTLQPNESSGDLQAV 881
                                                |:|  .|||..:..|
Zfish   811 ------------------------------------SEDPRAWKTFINTVR-------------- 825

  Fly   882 DSSVRNGLSGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLS 946
                                                                     .::.:.|:
Zfish   826 ---------------------------------------------------------CTTAAHLA 833

  Fly   947 FIAGNQSKDVSGMPDPLDAKSANLVSNSLRKSKLKHDDPASLYKGPGGAELPKEVLADLTQFTRK 1011
            .:.   .|:||..|           ||        |:                       :||
Zfish   834 LMV---PKNVSFYP-----------SN--------HE-----------------------RFT-- 851

  Fly  1012 RSHAVIDVWWLYDDGGLTLLLPYIISTRRTWQSCKLRVYALANKNSELEFEQRSMASLLSKFRID 1076
              ...|||||:..|||:.:|||:::...:.|:.||:|::.:|..:......::.:|:.|.:.|::
Zfish   852 --DGYIDVWWIVHDGGMLMLLPFLLKQHKVWRKCKMRIFTVAQMDDNSIQMKKDLATFLYQLRLE 914

  Fly  1077 Y---------SDL-------TLIPD----ITKKPQETSTQFFNE--LIKD--------------- 1104
            .         ||:       ||:.:    :.|:.:.:|.:...|  |:||
Zfish   915 AEVEVVEMHDSDISAYTYERTLMMEQRSQMLKQMRLSSAERDREAQLVKDRHSLIRMGSLYSDEE 979

  Fly  1105 ----FVVTEKDGENGTSSRATL---NEDDALITDDDLLAVQ-DKTN-----RYLRLREYLREQST 1156
                .::.||:....||.:...   |.::|.....:|:::: |::|     ..::|.|.:..:|.
Zfish   980 EETIEILPEKNQMTWTSEKIEAERRNRNNAPENFRELISIKPDQSNVRRMHTAVKLNEVIVNKSH 1044

  Fly  1157 KSDLVVMTLPMPRKNIVSAPLYMAWLESLSRDMPPFLFVRGNQTSVLTFYS 1207
            .:.||::.:|.|.:|......||.:||.|:..:...|.|||....|:|.||
Zfish  1045 DARLVLLNMPGPPRNQEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_2	155..1207	CDD:459263	319/1227 (26%)
slc12a4	XP_691291.2	2a30	50..1095	CDD:273347	321/1238 (26%)