Protein Alignment Ncc69 and slc12a10.3

DIOPT Version :9

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: XP_021333240.1
• Gene: slc12a10.3 / 562763
• ZFINID: ZDB-GENE-060503-518
• Length: 1001
• Species: Danio rerio
• Alignment Length: 1123
• Identity: 435/1123 - (38%)
• Similarity: 633/1123 - (56%)
• Gaps: 183/1123 - (16%)

  Fly   121 PQNEESDESNDSQEERELLDNEYDTKYGKSFRHFTREALPRLDNYRN---MMSIQAAYRPTLDEL 182
            |:|...|.:.:.::...:::.|.|.:....|...  :..|:.:.|..   ...|::| ||:||.|
Zfish    23 PENNLQDVTMNLEKVDYVMEQEQDKRKMSIFNPL--DPTPKFEFYAKDTWTGRIKSA-RPSLDVL 84

  Fly   183 HNATLVGKNTHSLTRNQDPESGIL------NG-----VLKFGWIKGVLVRCLLNIWGVMLFLRLS 236
            .             ::.||:.  |      :|     :::|||:.||::||:||||||::||||.
Zfish    85 R-------------KSPDPDD--LPPPPEDDGRPKVKLVRFGWVLGVMIRCMLNIWGVIMFLRLP 134

  Fly   237 WVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMISRSLGPEFGGSIGLIFSL 301
            |:..|||:|..:|:|..:..:|||||.|:|||||||.:..||||::||||||||.|..|||:||.
Zfish   135 WITSQAGIILTYVIIFMSVTITTITATSVSAISTNGKVYSGGTYFLISRSLGPELGAPIGLLFSF 199

  Fly   302 ANAVACAMYVVGFCESMLAMMTTFGWEIIDGGVQDVRIIGCITILLLLIIVVVGMEWEAKAQIGL 366
            |||:||::..|||.|::..::.....:::| .|.||||||.||:.:||:|...||.|||||||..
Zfish   200 ANALACSLNTVGFAETVRDVLKENNAQMVD-DVNDVRIIGTITVCILLLITFAGMAWEAKAQILF 263

  Fly   367 LIILLVAIGDFVIGSFIGPKSDAEMAKGFLGYNATLFKNNLFADYRPEKGGIQHDFFSVFAIFFP 431
            .|.||:::.::.:|:.: |.:..:.|.||.||.|.:|.:||...:|.:.|    .||.:|:||||
Zfish   264 FIALLISLANYFVGTLL-PPTPEKQAVGFFGYRAEIFVDNLLPSFRGKDG----SFFRMFSIFFP 323

  Fly   432 AATGILAGANISGDLKDPQKSIPKGTILAIVITTGTYLIMVLQCGATVARDATGNLSDVV----- 491
            :|||||:|.||.||||||...|||||:|||..||.:||::.:...|:|.|||:|||:|.:
Zfish   324 SATGILSGVNICGDLKDPSGGIPKGTLLAIFWTTVSYLLIAITVAASVVRDASGNLNDSLALDSS 388

  Fly   492 ---NGTFAFLDCQPG----------ECNYGLQNSFQVIELVSAFGPLIYAGCYAATLSSALASLV 543
               :|    |.|:.|          .|::||.|.||::...|..|.||..|.:||||||||..||
Zfish   389 IQCSG----LGCKLGWNFDHCEQNHTCSFGLANYFQILTTASGTGHLITIGIFAATLSSALGFLV 449

  Fly   544 SAPKVFQALCKDELYPKIVWFAKGYGKNNEPVRGYVLTFIIACAFILIGELNLIAPLISNFFLAA 608
            ||||:||.||||.:||.|.:|.||||||.||:|||:|.|.||.||||||:||.||||||||||.:
Zfish   450 SAPKIFQCLCKDNIYPYIGFFGKGYGKNQEPLRGYLLMFFIALAFILIGDLNTIAPLISNFFLCS 514

  Fly   609 YMLINFSTFHASLAKPVGWRPTFKYYNMWLSLLGAILCVAVMFLISWATALITFAAVLALYLIVA 673
            |.|||||.|||::.|..||||.:.|::.|.||..|.|...:|||.:|..||:|||.||:|...|.
Zfish   515 YGLINFSCFHATITKSPGWRPHYHYFSPWTSLFAAFLSFILMFLFTWWAALVTFAIVLSLLGYVT 579

  Fly   674 YRKPDVNWGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQILVLSGLPNTRPVLVDLAYMLTKNL 738
            |:||.:|||::.||..|..||.....|..||:||||:|||.|||:|.||.||.|||.....|||:
Zfish   580 YKKPKINWGTSYQASFYNMALSFSMSLTGVEDHVKNFRPQCLVLTGPPNVRPALVDFVGTFTKNI 644

  Fly   739 SLLVCGHVLKGSSSQKYRTYLQERAGNWFRKHRVKGFYALVDGEDFESGTRALMQATGIGKLKPN 803
            ||::||::.......::..:..:...:|..:.:|:.||.....:....||.:||||:|:||||||
Zfish   645 SLMICGNIFMVEEKSRFPQHSTDMLVDWLNQRKVRAFYTSFTADSLTEGTHSLMQASGLGKLKPN 709

  Fly   804 IILMGYKTDWQTCDHKELDQYFNVMHKALDMYLSVAILRVPQGLDCSQVLGSQDGWKTVSDVPRT 868
            .:::||||:||.|..:.|..|||.:..|.|....:|:||:..|||..:.|.|
Zfish   710 TLVLGYKTNWQECKPERLQDYFNTISDAFDSSYGIAVLRMMDGLDIREDLTS------------- 761

  Fly   869 LQPNESSGDLQAVDSSVRNGLSGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMR 933
                               |.|.:||:.:....:..::.|:  .:::||
Zfish   762 -------------------GRSSAIDNPAFEADENTKSENE--ETDRNS---------------- 789

  Fly   934 SWPGAASSTSDLSFIAGNQSKDVSGMPDPLDAKSANLVSNSLRKSKLKHDDPASLYKGPGGAELP 998
                                 |:|                         ||        |..:..
Zfish   790 ---------------------DIS-------------------------DD--------GSNDQV 800

  Fly   999 KEVLADLTQFTRKRSHAVIDVWWLYDDGGLTLLLPYIISTRRTWQSCKLRVYALANKNSELEFEQ 1063
            |      |.|..|:....||::|:.||||||||:||:::.|..|:..|:||:.|.::.: ::.:.
Zfish   801 K------TVFQTKQGRKTIDIYWISDDGGLTLLVPYLLTRRNRWKKSKIRVFVLGDQET-MQEDH 858

  Fly  1064 RSMASLLSKFRIDYSDLTLIPDITKKPQETSTQFFNELIKDFVVTEKDGENGTSSRATLNEDDAL 1128
            :.|..||.:||::..|:.:|.|:.|.|...:.|.:::.:..|.:||:      .||..|.|...|
Zfish   859 KDMKMLLKRFRLEIEDIIVITDVDKPPLAKNLQRYDDSVAPFRLTEE------QSRGDLQEFRRL 917

  Fly  1129 ----ITDDDLLAVQDKTNRYLRLREYLREQSTKSDLVVMTLPMPRKNIVSAPLYMAWLESLSRDM 1189
                ::|.||.|::.|..|.:||.|.:::.|..:.|||::||:|..|..|: |||||:|:||..:
Zfish   918 NPWTVSDKDLEAIRPKIERTVRLNEIIKKNSNHAALVVVSLPVPDLNCPSS-LYMAWMEALSFGI 981

  Fly  1190 P-PFLFVRGNQTSVLTFY 1206
            . |.|.:||||.:|:|||
Zfish   982 HCPALLIRGNQENVMTFY 999

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588	10/41 (24%)
		2a30	155..1207	CDD:273347	429/1089 (39%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	97/157 (62%)
		SLC12	724..1207	CDD:281515	140/488 (29%)
slc12a10.3	XP_021333240.1	SLC12	54..1000	CDD:332077	429/1092 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594115
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	817	1.000	Inparanoid score	I458
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D135130at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6412
orthoMCL	1	0.900	-	-		OOG6_101360
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X709
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.770