DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ncc69 and slc7a1a

DIOPT Version :9

Sequence 1:	NP_001261758.1	Gene:	Ncc69 / 39410	FlyBaseID:	FBgn0036279	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	XP_021327949.1	Gene:	slc7a1a / 559627	ZFINID:	ZDB-GENE-091116-69	Length:	651	Species:	Danio rerio

Alignment Length:	549	Identity:	113/549 - (20%)
Similarity:	186/549 - (33%)	Gaps:	189/549 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 GVIKGGGTYYMISRSLGPEFGGSIGLIFSLANAVACAMYVVGFC------------ESMLAMMTT 324
            |...|.|.|.:.........|.:|.|.|.:|   |.|..:.|.|            .:.|....|
Zfish    43 GSTLGAGVYVLAGAVARENAGPAIVLSFLIA---ALASVLAGLCYAEFGARVPKTGSAYLYSYVT 104

  Fly   325 FG--WEIIDG---------GVQDV---------RIIG------C--------------------- 342
            .|  |..|.|         |...|         .:||      |
Zfish   105 VGELWAFITGWNLILSYVIGTSSVARAWSATFDELIGKHIEHFCRQYMSMNAPGVLAEYPDMFSV 169

  Fly   343 ITILLLLIIVVVGMEWEAKAQ-----IGLLIILLVAIGDFVIGSF----IGPKSDAEMAKGFLGY 398
            ..||.|..::..|::..|...     |.:|::|.:.:...|.|:.    :.|..........|
Zfish   170 FIILTLTGLLAFGVKESAMVNKVFTCINILVLLFMVVSGLVKGTLKNWHLDPDEILNATNSTL-- 232

  Fly   399 NATLFKNNLFADYRPEKGGIQHDFFSVFAIFFP-AATGILAG--------------ANISGDLKD 448
            |||   ..|.::....:||           |.| ..||:|:|              |....::|:
Zfish   233 NAT---QPLPSEEMLGQGG-----------FMPFGFTGVLSGAATCFYAFVGFDCIATTGEEVKN 283

  Fly   449 PQKSIPKGTILAIVITTGTYLIMVLQCGATVARDATGNLSDVVNGTFAFLDCQPGECNYGLQNSF 513
            ||::||.|.:.:::|....|.      |.:.|      |:.::  .:..||     .|..|..:|
Zfish   284 PQRAIPIGIVSSLLICFVAYF------GVSAA------LTMMM--PYYMLD-----KNSPLPVAF 329

  Fly   514 QVIELVSAFGPLIYA---GCYAATLSSALASLVSAPKVFQALCKDELYPKIVWFAKGYGKNNE-P 574
            :.:....|    .||   |...|..:|.|.::...|:|..|:..|.|..|   |..|..:..: |
Zfish   330 KYVGWEGA----TYAVAVGSLCALSTSLLGAMFPMPRVLWAMADDGLLFK---FMAGISERTKTP 387

  Fly   575 VRGYVLTFIIACAFILIGELNLIAPLISNFFLAAYMLI------------NFS-TFH-------- 618
            ::..:::..:|.....:.:|..:..|:|...|.||.|:            .|| |:|
Zfish   388 IKATIMSGFLAAIMAFLFDLKDLVDLMSIGTLLAYTLVAACVLVLRYQPEQFSQTYHIANTHEDM 452

  Fly   619 ---ASLAKP-------VGWRPTFK----------------YYNMWLSLLGAILCVAVMFLI---- 653
               .:::.|       |..|.:||                ..|:..||||.::....:..:
Zfish   453 EMSETISTPSMGILPGVEERFSFKNLLFPDIIEPSNLSGFTVNICTSLLGLLILSFSLLAVRGGI 517

  Fly   654 -SWATALITFAAVLALYLIVAY---RKPD 678
             ||  .:||.|.:..|.:||.:   |:|:
Zfish   518 ASW--NIITLAVLFGLCVIVTFIIWRQPE 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588
		2a30	155..1207	CDD:273347	113/549 (21%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	47/214 (22%)
		SLC12	724..1207	CDD:281515
slc7a1a	XP_021327949.1	2A0303	4..603	CDD:273330	113/549 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910