Protein Alignment Ncc69 and slc12a7a

DIOPT Version :10

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: XP_005171306.1
• Gene: slc12a7a / 558214
• ZFINID: ZDB-GENE-070912-696
• Length: 1117
• Species: Danio rerio
• Alignment Length: 1301
• Identity: 308/1301 - (23%)
• Similarity: 502/1301 - (38%)
• Gaps: 419/1301 - (32%)

  Fly   120 DPQNEESDESNDS-----------QEERELLDNEY-DTKYGKSFRHFTREALPRLDNYRNMMSIQ 172
            |...||..|..::           :|...|:..:: |:.|||:...:..|    :|:...:.|:
Zfish    23 DGLKEEDKEEPETAAGHYPGDETPRETSSLISTDHDDSTYGKNMALYEEE----MDSTPMVSSL- 82

  Fly   173 AAYRPTLDELHNATLVGKNTHSLTRNQDPES--GI----LNGVLKFGWIKGVLVRCLLNIWGVML 231
                  |::|.|.|.:   |.....:::.||  ||    :||. :.|...||.:.|..||.||:|
Zfish    83 ------LNKLANYTNI---TQGAVEHEEAESEDGIQRVTVNGP-QMGTFIGVFLPCTQNILGVIL 137

  Fly   232 FLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMISRSLGPEFGGSIG 296
            ||||:|:||.||::|...::....|.|.:||:|||||:||||:..||:||||||:||||.||::|
Zfish   138 FLRLTWIVGTAGILEALAVVFMCCACTMLTAISMSAIATNGVVPAGGSYYMISRALGPEIGGAVG 202

  Fly   297 LIFSLANAVACAMYVVGFCESMLAMM----TTFGWEIIDGGVQDVRIIGCITILLLLIIVVVGME 357
            |.|.|....|.:||::|..|..|..:    ..|......|...::||.|...:.::.::|.||::
Zfish   203 LCFYLGTTFAGSMYILGTMEIFLTYIMPSAAVFEANNPTGMQNNMRIYGTCCLAIMTLVVFVGVK 267

  Fly   358 WEAKAQIGLL---IILLVAIGDFVIGSFIGPKS-------------------------------- 387
            :..|..:..|   ::.::||...||.|.|.|.|
Zfish   268 YVNKLSLVFLSCVVLSIMAIYAGVIQSAIKPSSFTICLLGNRTLQHFGKSGKFDKCMKTEVIDNI 332

  Fly   388 -------------------------DAEMAKGFLG-------------YNATLFKNNLFAD---- 410
                                     :.....|.|.             |..|:.|.|:.::
Zfish   333 TKPTELWYHFCNGTCDEYFNLNELTEISAVPGLLSNAITENLWSRYGEYRTTVEKENITSEAALS 397

  Fly   411 YRPE--KGGIQHD---FFSVF-AIFFPAATGILAGANISGDLKDPQKSIPKGTILAIVITTGTYL 469
            ..||  ...:.:|   ||::. .|:||:.|||:||:|.||||:|||:|||.|||:||..|:..|:
Zfish   398 SEPEVLNSYVVNDMATFFTLLVGIYFPSVTGIMAGSNRSGDLRDPQRSIPTGTIMAIATTSFIYI 462

  Fly   470 IMVLQCGA----TVARDATGNLSDVVNGTFAFLDCQPGECNYGLQNSFQVIELVSAFGP-LIYAG 529
            ..|:..||    .|.||..|   |.||...                   |:..::...| :|..|
Zfish   463 SCVVLFGACFEGVVLRDKYG---DSVNKNL-------------------VVATLAWPSPWVIVIG 505

  Fly   530 CYAATLSSALASLVSAPKVFQALCKDELYPKIVWFAKGYGKN---NEPVRGYVLTFIIACAFILI 591
            .:.:...:.|.||..||::.||:.:|.:.|    |.:.:|::   .||....:||..|....|||
Zfish   506 SFFSCCGAGLQSLTGAPRILQAIARDGIMP----FLQVFGRSKSGGEPTWALLLTAAICEIGILI 566

  Fly   592 GELNLIAPLISNFFLAAYMLINFSTFHASLAKPVGWRPTFKYYNMWLSLLGAILCVAVMFLISWA 656
            ..|:.:||::|.|||..|:.:|.:....:|.:...|||.||:|:..||.||..|.:::||:.||.
Zfish   567 ASLDAVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWSLSFLGMSLSLSLMFVSSWY 631

  Fly   657 TALITFAAVLALYLIVAYRKPDVNWGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQILVL---- 717
            .||:.......:|..:.||.....||...:..:...|..::.:|...:.|.||:|||:|||
Zfish   632 YALVVILIAGCIYKYIEYRGAVKEWGDGLRGLSLNAARYALIKLEEAQPHTKNWRPQLLVLMKLD 696

  Fly   718 SGLPNTRPVLVDLAYMLTKNLSLLVCGHVLKGS----------SSQKYRTYLQERAGNWFRKHRV 772
            :.|....|.|:.....|.....|.:...||:|:          :.|..:..:        .|.:.
Zfish   697 TDLTVKHPRLLSFTSQLKAGKGLTIVCSVLEGTFMVRGADAKLAEQNIKAAM--------AKEKT 753

  Fly   773 KGFYALVDGEDFESGTRALMQATGIGKLKPNIILMGYKTDWQTCDHKELDQYFNVMHKALDMYLS 837
            |||..:|...:...|...|:|:.|:|.:|.|.:|:.:..:|:..:
Zfish   754 KGFCHVVVSSNQRDGFSHLIQSAGLGGMKHNAVLVAWPANWKQAE-------------------- 798

  Fly   838 VAILRVPQGLDCSQVLGSQDGWKTVSDVPRTLQPNESSGDLQAVDSSVRNGLSGSIDSLSRNVSQ 902
                             |...||...:..|     |::...||:             .:::||..
Zfish   799 -----------------SSLSWKNFIETVR-----ETTAAHQAL-------------LVAKNVDT 828

  Fly   903 EDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGNQSKDVSGMPDPLDAKS 967
            ...|:::|
Zfish   829 FPSNQDRL--------------------------------------------------------- 836

  Fly   968 ANLVSNSLRKSKLKHDDPASLYKGPGGAELPKEVLADLTQFTRKRSHAVIDVWWLYDDGGLTLLL 1032
                                                         :...|||||:..||||.:||
Zfish   837 ---------------------------------------------AEGTIDVWWIVHDGGLLMLL 856

  Fly  1033 PYIISTRRTWQSCKLRVYALANKNSELEFEQRSMASLLSKFRIDYS----------------DLT 1081
            |:::...:.|:.||:|::.:|..:......::.:...|...|:|..                :.|
Zfish   857 PFLLRQHKVWRKCKMRIFTVAQMDDNSIQMKKDLQMFLYHLRLDAKVEVVEMNAGDISAFTYEKT 921

  Fly  1082 LIPD----ITKKPQETSTQFFNEL----------IKDFVVTEKDGENGTSSRATLNEDD------ 1126
            |:.:    :.|:.|.:.|:...|:          |:.....||...|.....||:|.|:
Zfish   922 LVMEQRSQMLKQMQLSKTEREREIQSISDESRISIRRKPCGEKQTHNSKLKVATVNLDEEAQLIH 986

  Fly  1127 -------------ALITDD--------------------------DLLAVQ------DKTN---- 1142
                         |..|.|                          |:..::      |:||
Zfish   987 DKNTKSHATLVEKATPTSDRVHMTWTKEKLIGERNRLRDASMHVRDIFNMKPEWENLDQTNVRRM 1051

  Fly  1143 -RYLRLREYLREQSTKSDLVVMTLPMPRKNIVSAPLYMAWLESLSRDMPPFLFVRGNQTSVLTFY 1206
             ..::|.|.:.::|..:.||::.:|.|.||......||.:||.|:..:...|.|||....|:|.|
Zfish  1052 HTAVKLNEVVVKKSKGAQLVLLNMPGPPKNKGGDENYMEFLEVLTEGLDHVLLVRGGGREVITIY 1116

  Fly  1207 S 1207
            |
Zfish  1117 S 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_2	155..1207	CDD:459263	296/1252 (24%)
slc12a7a	XP_005171306.1	AA_permease_2	62..1117	CDD:459263	299/1260 (24%)