Protein Alignment Ncc69 and Slc12a3

DIOPT Version :9

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: NP_062218.3
• Gene: Slc12a3 / 54300
• RGDID: 3686
• Length: 1002
• Species: Rattus norvegicus
• Alignment Length: 1098
• Identity: 441/1098 - (40%)
• Similarity: 633/1098 - (57%)
• Gaps: 181/1098 - (16%)

  Fly   145 TKYGKSFRHFTREALPRLDNYRN--MMSIQAAYRPTLDELHN-ATLVGKNTHSLTRNQDPESGIL 206
            |.|.::|.:.|.:.:|..::|.|  :.......||||.:||: ....|.:.|:|..:..|...:.
  Rat    48 TLYLRTFGYNTIDVVPAYEHYANSALPGEPRKVRPTLADLHSFLKQEGSHLHALAFDGRPGHELT 112

  Fly   207 NGV----------------LKFGWIKGVLVRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTT 255
            :|:                ::|||:|||::||:||||||:|:|||.|:..|||::..:::||.:.
  Rat   113 DGLVEDETGANSEKSPGEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWLIILLSV 177

  Fly   256 AVTTITALSMSAISTNGVIKGGGTYYMISRSLGPEFGGSIGLIFSLANAVACAMYVVGFCESMLA 320
            .||:||.||:|||||||.:|.||||::||||||||.||||||||:.||||..||:.|||.|::..
  Rat   178 MVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRD 242

  Fly   321 MMTTFGWEIIDGGVQDVRIIGCITILLLLIIVVVGMEWEAKAQIGLLIILLVAIGDFVIGSFIGP 385
            ::...|..|:| .:.|:||||.:|:.:||.|.:.|||||:|||:...::::|:..::::|:.| |
  Rat   243 LLQENGTPIVD-PINDIRIIGVVTVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLI-P 305

  Fly   386 KSDAEMAKGFLGYNATLFKNNLFADYRPEKGGIQHDFFSVFAIFFPAATGILAGANISGDLKDPQ 450
            .|..:.:|||..|:..:|..||..|:|    ||...||.:|:||||:|||||||||||||||||.
  Rat   306 ASKDKASKGFYSYHGDIFVQNLVPDWR----GIDGSFFGMFSIFFPSATGILAGANISGDLKDPA 366

  Fly   451 KSIPKGTILAIVITTGTYLIMVLQCGATVARDATGNLSDVVNG------------TFAFLDC-QP 502
            .:|||||::||..||.:||.:....|:.|.|||:|:::|.|..            .:.|.:| |.
  Rat   367 VAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGDVNDTVTPGPGLCEGLACGYGWNFTECSQQ 431

  Fly   503 GECNYGLQNSFQVIELVSAFGPLIYAGCYAATLSSALASLVSAPKVFQALCKDELYPKIVWFAKG 567
            ..|.|||.|.:|.:.:||||.|||.||.:.||||||||.||||.||||.||:|:|||.|.:|.||
  Rat   432 HSCRYGLINYYQTMSMVSAFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKG 496

  Fly   568 YGKNNEPVRGYVLTFIIACAFILIGELNLIAPLISNFFLAAYMLINFSTFHASLAKPVGWRPTFK 632
            ||||.||||||:|.:.||.|||:|.|||.|||:||||||.:|.|||||.||||:....||||:|:
  Rat   497 YGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFR 561

  Fly   633 YYNMWLSLLGAILCVAVMFLISWATALITFAAVLALYLIVAYRKPDVNWGSTTQAQTYKNALMSV 697
            ||:.|.:|.||::.|.:|||::|..|||....||.|.|.|.|:||:|||||:.||.:|..||...
  Rat   562 YYSKWAALFGAVISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYS 626

  Fly   698 QQLNNVEEHVKNYRPQILVLSGLPNTRPVLVDLAYMLTKNLSLLVCGHVLKGSSSQKYRTYLQER 762
            ..||.||:|:||||||.|||:|.||.||.|||.....|:||||::|||||.....|:........
  Rat   627 VGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVSTFTQNLSLMICGHVLIAPGKQRVPELRLIA 691

  Fly   763 AGN--WFRKHRVKGFYALVDGEDFESGTRALMQATGIGKLKPNIILMGYKTDWQTCDHKELDQYF 825
            :|:  |..|.::|.||:.|..||..||.:.||||:|:|::||||:::|:|.:||:.....|:.|.
  Rat   692 SGHTKWLNKRKIKAFYSDVIAEDLRSGVQILMQASGLGRMKPNILVVGFKKNWQSAHPATLEDYI 756

  Fly   826 NVMHKALDMYLSVAILRVPQGLDCSQVLGSQDGWKTVSDVPRTLQPNESSGDLQAVDSSVRNGLS 890
            .::|.|.|....|.|:|:.:||:.|:.|
  Rat   757 GILHDAFDFNYGVCIMRMREGLNVSEAL------------------------------------- 784

  Fly   891 GSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGNQSKD 955
                       |.......||..||.|
  Rat   785 -----------QTHTAPEALVQEEQTS-------------------------------------- 800

  Fly   956 VSGMPDPLDAKSANLVSNSLRKSKLKHDDPASLYKGPGGAELPKEVLADLTQFTRKRSHAVIDVW 1020
                                                              |.|..::....||::
  Rat   801 --------------------------------------------------TIFQSEQGKKTIDIY 815

  Fly  1021 WLYDDGGLTLLLPYIISTRRTWQSCKLRVYALANKNSELEFEQRSMASLLSKFRIDYSDLTLIPD 1085
            ||:||||||||:||::..::.|..||:||: :..:.:.::.|::::.|||||||:.:.::.::||
  Rat   816 WLFDDGGLTLLIPYLLHRKKRWGKCKIRVF-VGGQINRMDEERKAIISLLSKFRLGFHEVHVLPD 879

  Fly  1086 ITKKPQETSTQFFNELIKDFVVTEKDGENGTSSRATLNED-DALITDDDLLAVQDKTNRYLRLRE 1149
            |.:|||...|:.|.::|..|.:  .||....::.|.:..| ...|:|:::...:.|:.|.:||.|
  Rat   880 INQKPQVEHTKRFEDMIAPFRL--NDGFKDEATVAEMRRDYPWKISDEEINKNRIKSLRQVRLNE 942

  Fly  1150 YLREQSTKSDLVVMTLPMPRKNIVSAPLYMAWLESLSRDM-PPFLFVRGNQTSVLTFY 1206
            .|.:.|..:.|:::|||:.||....:.|||||||:||:|: ||.|.:||||.:|||||
  Rat   943 ILLDYSRDAALIILTLPIGRKGKCPSSLYMAWLETLSQDLSPPVLLIRGNQENVLTFY 1000

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588	11/39 (28%)
		2a30	155..1207	CDD:273347	438/1088 (40%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	99/157 (63%)
		SLC12	724..1207	CDD:281515	139/487 (29%)
Slc12a3	NP_062218.3	2a30	57..1001	CDD:273347	438/1089 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352208
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	993	1.000	Inparanoid score	I287
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D135130at33208
OrthoFinder	1	1.000	-	-		FOG0001536
OrthoInspector	1	1.000	-	-		mtm8955
orthoMCL	1	0.900	-	-		OOG6_101360
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X709
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.910