Protein Alignment Ncc69 and kcc

DIOPT Version :9

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Alignment Length: 1281
• Identity: 336/1281 - (26%)
• Similarity: 519/1281 - (40%)
• Gaps: 403/1281 - (31%)

  Fly   125 ESDESNDSQEERELLDNE-----YDTKYGKSFRHFTREALPRLDNYRNMMSIQAAYRPTL----D 180
            :|:.:.|..:|.|::.:|     ::||...|.           |.:|...:.:::..|.|    |
  Fly     2 QSNSAKDDSDEMEIIPSEHNGTVHETKNEDSG-----------DIHRAEENQKSSIDPNLYLYDD 55

  Fly   181 EL----HNATLVG-----KNTHSLTRNQDPESGILNGVLKFGWIKGVLVRCLLNIWGVMLFLRLS 236
            :|    |.:|.:.     :||  :....||::.......:.|.:.||.:.|:.||:||:||:||:
  Fly    56 DLETRPHISTFISSIANYENT--IPAATDPDAKPAAPSARMGTLIGVFLPCIQNIFGVILFIRLT 118

  Fly   237 WVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMISRSLGPEFGGSIGLIFSL 301
            ||||.||.:.||:::||...||.:||:|||||:||||:..||:|:||||||||||||::|::|..
  Fly   119 WVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYT 183

  Fly   302 ANAVACAMYVVGFCESMLAMMTTFGWEII--------DGGVQDVRIIGCITILLLLIIVVVGMEW 358
            ...:|.|||:||..|.:|..|..  |..|        |....:.|:.|.:.::.:.:||.:|:::
  Fly   184 GTTLAAAMYIVGAVEIVLTYMAP--WASIFGDFTKDADAMYNNFRVYGTLLLIFMGLIVFLGVKF 246

  Fly   359 EAK-AQIGL----LIILLVAIGDF------------VIG----------------SFIG----PK 386
            ..| |.:.|    |.|:.|.:|.|            |:|                ||:.    |.
  Fly   247 VNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLENCTKEDSFLRDIYCPD 311

  Fly   387 SDAE---------MAKGFLGYNATLFKNNLFADYRPEKG-------------------------G 417
            ...|         ..||..|..:.:|.:|:|..:. |||                         .
  Fly   312 GKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFL-EKGQFISYGKSAIDIENTSGESYNQIMAD 375

  Fly   418 IQHDFFSVFAIFFPAATGILAGANISGDLKDPQKSIPKGTILAIVITTGTYLIMVLQCGATV--- 479
            |...|..:..||||:.|||:||:|.||||.|.|||||.|||.||:.|:..||..|:....||
  Fly   376 ITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDNL 440

  Fly   480 -ARDATGNLSDVVNGTFAFLDCQPGECNYGLQNSFQVIELVSAFGPLIYAGCYAATLSSALASLV 543
             .||..|   ..:.|....       .|....|.:           :|..|.:.:||.:.|.||.
  Fly   441 LLRDKFG---QSIGGKLVV-------ANIAWPNQW-----------VILIGSFLSTLGAGLQSLT 484

  Fly   544 SAPKVFQALCKDELYPKIVWFAKGYGKNNEPVRGYVLTFIIACAFILIGELNLIAPLISNFFLAA 608
            .||::.||:.:||:.|.:..|||. .|..||.|..:||.:|....||:|.::|:|||:|.|||..
  Fly   485 GAPRLLQAIARDEIIPFLAPFAKS-SKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMC 548

  Fly   609 YMLINFSTFHASLAKPVGWRPTFKYYNMWLSLLGAILCVAVMFLISWATALITFAAVLALYLIVA 673
            |..:|.:....:|.:...|||.||:|:..|||:|..||::||.:.||..|||.....:.:|..:.
  Fly   549 YGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIE 613

  Fly   674 YRKPDVNWGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQILVLSG-----LPNTRPVLVDLAYM 733
            ||..:..||...:......|..|:.:|.....|.||:||||||||.     ||..|.:. ..|..
  Fly   614 YRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKLNDNLLPKYRKIF-SFATQ 677

  Fly   734 LTKNLSLLVCGHVLKGSSSQKYRTYLQERAGNWFRKH----RVKGFYALVDGEDFESGTRALMQA 794
            |.....|.:|..|:||..::.....:..:|  ..||:    :||||..::..:....|..:::|.
  Fly   678 LKAGKGLTICVSVIKGDHTKITNKAVDAKA--TLRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQT 740

  Fly   795 TGIGKLKPNIILMGYKTDWQTCDHKELDQYFNVMHKALDMYLSVAILRVPQGLDCSQVLGSQDG- 858
            .|:|.:|||.:::|:...|:                                         |:|
  Fly   741 IGLGGMKPNTVIIGWPYSWR-----------------------------------------QEGR 764

  Fly   859 --WKTVSDVPRTLQPNESSGDLQAVDSSVRNGLSGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIV 921
              |||
  Fly   765 NSWKT------------------------------------------------------------ 769

  Fly   922 KLRFKQGLRRMRSWPGAASSTSDLSFIAGNQSKDVSGMPDPLDAKSANLVSNSLRKSKLKHDDPA 986
               |.|.:|.:.:...|......::|.                                    |.
  Fly   770 ---FIQTVRTVAACHMALMVPKGINFY------------------------------------PE 795

  Fly   987 SLYKGPGGAELPKEVLADLTQFTRKRSHAVIDVWWLYDDGGLTLLLPYIISTRRTWQSCKLRVYA 1051
            |.:|..|.                      ||:||:..||||.:|||:::...|||::||||::.
  Fly   796 SNHKIGGN----------------------IDIWWIVHDGGLLMLLPFLLKQHRTWRNCKLRIFT 838

  Fly  1052 LAN------------------------------KNSE---------LEFEQRSMA---------- 1067
            :|.                              .||:         |..|||:..
  Fly   839 VAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRNQMLRALGLNKKE 903

  Fly  1068 -SLLSKFRIDYSD------LTLIP-------DITKKPQETSTQFFNELIK-----DFVVTEK--- 1110
             |.:.:..:||.:      ::|:.       |.||  ..:..:|.:..|:     |....||
  Fly   904 NSKVVQTIMDYKETPSDNKMSLVQTIVDHHYDATK--TASKVRFADPTIEETQHHDSQNDEKRNS 966

  Fly  1111 ---DG-ENGTSSRATLNEDDALITDDDLLAVQDKTNRY--------LRLREYLREQSTKSDLVVM 1163
               || ||..:...|.|:|::....|.......|.:.:        ::|.|.:.|:|..:.||:|
  Fly   967 IDLDGPENADTPETTSNKDESTEKADGDFKSSVKPDEFNVRRMHTAIKLNEVIVEKSQDAQLVIM 1031

  Fly  1164 TLPMPRKNIVS--APLYMAWLESLSRDMPPFLFVRGNQTSVLTFYS 1207
            .||.|.:.:.:  ...||.:||.|:..:...|.|||....|:|.||
  Fly  1032 NLPGPPREVRAERERNYMEFLEVLTEGLEKVLMVRGGGREVITIYS 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588	9/46 (20%)
		2a30	155..1207	CDD:273347	326/1244 (26%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	60/157 (38%)
		SLC12	724..1207	CDD:281515	105/574 (18%)
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	323/1221 (26%)
		SLC12	674..1077	CDD:281515	104/568 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467889
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2083
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20017at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11827
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850