Protein Alignment Ncc69 and Slc12a4

DIOPT Version :9

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: NP_062102.1
• Gene: Slc12a4 / 29501
• RGDID: 3687
• Length: 1085
• Species: Rattus norvegicus
• Alignment Length: 1268
• Identity: 313/1268 - (24%)
• Similarity: 493/1268 - (38%)
• Gaps: 397/1268 - (31%)

  Fly   122 QNEESDESNDSQEERELLD-------NEYDTKYGKSFRHFTREALPRLDNYRNMMSIQAAYRPTL 179
            :.|:||...:.:|....|.       |:|   |.::...|..|    ||           .||.:
  Rat    33 EREDSDGQGNHRENSPFLSPLDASRGNDY---YDRNLALFEEE----LD-----------IRPKV 79

  Fly   180 DELHNATLVGK------NTHSLTRNQDPESGILNG-------VLKFGWIKGVLVRCLLNIWGVML 231
                 ::|:||      .|.....:::.|||  .|       ....|.:.||.:.||.||:||:|
  Rat    80 -----SSLLGKLVSYTNLTQGAKEHEEAESG--EGGRRRAAKAPSMGTLMGVYLPCLQNIFGVIL 137

  Fly   232 FLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMISRSLGPEFGGSIG 296
            ||||:|:||.|||::..:::|.....|.:||:|||||:||||:..||:|:||||||||||||::|
  Rat   138 FLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVG 202

  Fly   297 LIFSLANAVACAMYVVGFCESMLAMMTTFGWEIIDGGVQD--------VRIIGCITILLLLIIVV 353
            |.|.|....|.|||::|..|.:|..:..........|..|        :|:.|.|.:..:.::|.
  Rat   203 LCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGTHDMSSATLNNMRVYGTIFLTFMTLVVF 267

  Fly   354 VGMEWEAKAQIGLLIILLVAIGDFVIGS-------------FIG--------------------- 384
            ||:::..|.....|..::::|....:|.             .:|
  Rat   268 VGVKYVNKFASLFLACVIISILSIYVGGIKSAFDPPVFPVCMLGNRTLSRDQFDICAKTVVVDNE 332

  Fly   385 -------------PKSDAEMA------------KGFLGYNATLFKNNLFADYRPEKGGI--QH-- 420
                         |...|:..            .|..|..|.:.:.||::.|. |||.:  :|
  Rat   333 TVATRLWTFFCHSPNLTADSCDPYFLLNNVTEIPGIPGAAAGVLQENLWSAYL-EKGEVVEKHGL 396

  Fly   421 ----------------------DFFSVFAIFFPAATGILAGANISGDLKDPQKSIPKGTILAIVI 463
                                  .|..:..||||:.|||:||:|.||||:|.|||||.|||||||.
  Rat   397 PSTDTLGLKESLSLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIVT 461

  Fly   464 TTGTYLIMVLQCGA----TVARDATGN--LSDVVNGTFAFLDCQPGECNYGLQNSFQVIELVSAF 522
            |:..|...|:..||    .|.||..|:  ..::|.||.|:
  Rat   462 TSLVYFSSVILFGACIEGVVLRDKYGDGVSRNLVVGTLAW------------------------- 501

  Fly   523 GP---LIYAGCYAATLSSALASLVSAPKVFQALCKDELYPKIVWFAKGYGK-NNEPVRGYVLTFI 583
             |   :|..|.:.:|..:.|.||..||::.||:.||.:.|.:..|  |:|| |.||....:||.:
  Rat   502 -PSPWVIVVGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHGKANGEPTWALLLTAL 563

  Fly   584 IACAFILIGELNLIAPLISNFFLAAYMLINFSTFHASLAKPVGWRPTFKYYNMWLSLLGAILCVA 648
            ||...|||..|:::||::|.|||..|:.:|.:....:|.:...|||.||||:..||.||..||:|
  Rat   564 IAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLA 628

  Fly   649 VMFLISWATALITFAAVLALYLIVAYRKPDVNWGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQ 713
            :||:.||..||:.......:|..:.|:..:..||...:..:...|..::.:|.....|.||:|||
  Rat   629 LMFVSSWYYALVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQ 693

  Fly   714 ILVLSGLPN----TRPVLVDLAYMLTKNLSLLVCGHVLKGSSSQKY--RTYLQERAGNWFRKHRV 772
            :|||..|..    ..|.|:..|..|.....|.:.|.|::||..:.|  ....::...|.....:|
  Rat   694 LLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKV 758

  Fly   773 KGFYALVDGEDFESGTRALMQATGIGKLKPNIILMGYKTDWQTCDHKELDQYFNVMHKALDMYLS 837
            |||..:|.......|...|:|:.|:|.::.|.:::|:...|:.
  Rat   759 KGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQ---------------------- 801

  Fly   838 VAILRVPQGLDCSQVLGSQD--GWKTVSDVPRTLQPNESSGDLQAVDSSVRNGLSGSIDSLSRNV 900
                             |:|  .|||..|..|
  Rat   802 -----------------SEDPRAWKTFIDTVR--------------------------------- 816

  Fly   901 SQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGNQSKDVSGMPDPLDA 965
                     ...:...:|.:.|                     :::|...|..:.:.|
  Rat   817 ---------CTTAAHLALLVPK---------------------NIAFYPSNHERYLEG------- 844

  Fly   966 KSANLVSNSLRKSKLKHDDPASLYKGPGGAELPKEVLADLTQFTRKRSHAVIDVWWLYDDGGLTL 1030
                                                            |  |||||:..|||:.:
  Rat   845 ------------------------------------------------H--IDVWWIVHDGGMLM 859

  Fly  1031 LLPYIISTRRTWQSCKLRVYALANKNSELEFEQRSMASLLSKFRID---------YSDLTLIPDI 1086
            |||:::...:.|:.|::|::.:|..:......::.:|..|...|::         .||::.....
  Rat   860 LLPFLLRQHKVWKKCRMRIFTVAQMDDNSIQMKKDLAIFLYHLRLEAEVEVVEMHNSDISAYTYE 924

  Fly  1087 TKKPQETSTQFFNELIKDFVVTEKDGE----NGTSSRATL-----NEDDALITDDDLLAVQDKTN 1142
            .....|..:|...::  ....||:|.|    ....|...|     :|:|..:|..|.:.:....:
  Rat   925 RTLMMEQRSQMLRQM--RLTKTERDREAQLVKDRHSALRLESLYSDEEDESVTGADKIQMTWTRD 987

  Fly  1143 RYL---------------------------------RLREYLREQSTKSDLVVMTLPMPRKNIVS 1174
            :|:                                 :|.|.:..:|..:.||::.:|.|.||...
  Rat   988 KYMAEPWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPKNSEG 1052

  Fly  1175 APLYMAWLESLSRDMPPFLFVRGNQTSVLTFYS 1207
            ...||.:||.|:..:...|.|||....|:|.||
  Rat  1053 DENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588	7/38 (18%)
		2a30	155..1207	CDD:273347	302/1226 (25%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	60/161 (37%)
		SLC12	724..1207	CDD:281515	90/537 (17%)
Slc12a4	NP_062102.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	32..56		5/22 (23%)
		2a30	42..1085	CDD:273347	308/1257 (25%)
		SLC5-6-like_sbd	142..>303	CDD:294310	57/160 (36%)
		SLC12	709..1085	CDD:281515	90/536 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352207
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850