Protein Alignment Ncc69 and Slc12a8

DIOPT Version :10

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: NP_705889.2
• Gene: Slc12a8 / 266733
• RGDID: 628730
• Length: 705
• Species: Rattus norvegicus
• Alignment Length: 737
• Identity: 187/737 - (25%)
• Similarity: 296/737 - (40%)
• Gaps: 244/737 - (33%)

  Fly   174 AYRPTLDELHNATLVGKNTHSLTRNQ----------DPESGILNGVLKFGWIKGVLVRCLLNIWG 228
            |.|...:..|.|...|    :|.|:|          :|        :.||...||...|::||:|
  Rat     2 AQRSPQELFHEAAQQG----ALARSQPWWKIQLFMWEP--------VLFGTWDGVFTSCMINIFG 54

  Fly   229 VMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMISRSLGPEFGG 293
            |:||||..|:||..||:.|.:|:.....|..||.||...::.:|.:..||.|.|||..||.:.||
  Rat    55 VVLFLRTGWLVGNTGVLLGLLLVSFVILVALITVLSGIGVAEHGWMGSGGVYSMISSVLGGQMGG 119

  Fly   294 SIGLIFSLANAVACAMYVVGFCESMLAMMTTFGWEIIDGGVQDVRIIGCITILLLLIIVVVGMEW 358
            ::||::.....||.|||:.||.||:..::..       |.:..||.|....:|.||.|.:.|::|
  Rat   120 TVGLLYVFGQCVAGAMYLTGFAESISDLLGL-------GNIWAVRGISVAVLLALLGINLAGVKW 177

  Fly   359 EAKAQIGLLIILLVAIGDFVIGSFIGPKSDAEMAKGFLGYNATLFKNNLFADYRPEKGGIQHDFF 423
            ..:.|:.||.:|.|:..|||:|||    :..:...||:||:..|.::|:..:|.|.:     .||
  Rat   178 IIRLQLLLLSLLAVSTLDFVVGSF----THLDPEHGFIGYSPELLQSNILPEYSPGE-----SFF 233

  Fly   424 SVFAIFFPAATGILAGANISGDLKDPQKSIPKGTILAIVITTGTYLIMVLQCGATVARDATGNLS 488
            :||.:|||||||::||.|:.|||::|..|||.|::.|:.|:...|:|.....||...|:|
  Rat   234 TVFGVFFPAATGVMAGFNMGGDLREPADSIPLGSLAAVGISWFLYIIFAFLLGAVCTREA----- 293

  Fly   489 DVVNGTFAFLDCQPGECNYGLQNSFQVIELVSAFGPLIYAGCYAATLSSALASLVSAPKVFQALC 553
                                |::.|.:.|.||..|.|...|.|.::|:|.:..|..||::.|.:.
  Rat   294 --------------------LRSDFLIAEKVSLVGFLFLLGLYISSLASCMGGLYGAPRILQCIA 338

  Fly   554 KDELYPKIVWFAKGYGKNNEPVRGYVLTFIIACAFILIGELNLIAPLISNFFLAAYMLINFSTFH 618
            :|::.|.:.:...|.|.|..||....||.::..||:|:|::|::||:::..|:..|:.:::|.|.
  Rat   339 QDKVIPALAFLGNGKGPNKTPVAAICLTSLVTMAFVLVGQVNVLAPVVTINFMLTYIAVDYSYFA 403

  Fly   619 ASLA----------------------------------------------------------KPV 625
            .|:|                                                          :|:
  Rat   404 LSMAHCGLAQSPEPMPRQGPDALHCSEHLLQDKAPSYGSDTPAGSLSEGTLLEFTKDMDQLLQPI 468

  Fly   626 GW--------------------------------------------------------------- 627
            |.
  Rat   469 GGLESQPRSRDVNQVLKSQKHKCKKDAKQTLQDSFLLDAESPLSFSMGASERLSVASCGEQESYQ 533

  Fly   628 -----------------------------------------RPTFKYY---NMWLSLLGAILCVA 648
                                                     ||:..|.   |.|:|||||:..:.
  Rat   534 NQQTSRSESHDHLVPDLCTQPRANGEDFFLKCRLQEQQVQRRPSAFYVCMCNPWVSLLGALASLL 598

  Fly   649 VMFLISWATALITFAAVLALYLIVAYRKPDVNWGSTTQ---AQTYKNALM-SVQQLNNVEEHVKN 709
            :||:|.|...|.:......:||.:....|.:..||.:.   .|..|:.|: |.:.|.:..|.:
  Rat   599 IMFVIQWLYTLASMGVAALVYLYIGQASPGLYLGSASNFSFFQWMKSFLVPSCRSLRSTREQI-- 661

  Fly   710 YRPQILVLSGLPNTRPVLVDLA 731
                ||..|      |..||:|
  Rat   662 ----ILAPS------PAKVDMA 673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_2	155..1207	CDD:459263	187/737 (25%)
Slc12a8	NP_705889.2	AA_permease_2	34..>420	CDD:459263	144/434 (33%)