DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ncc69 and Slc12a1

DIOPT Version :9

Sequence 1:	NP_001261758.1	Gene:	Ncc69 / 39410	FlyBaseID:	FBgn0036279	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_001257546.1	Gene:	Slc12a1 / 25065	RGDID:	3685	Length:	1095	Species:	Rattus norvegicus

Alignment Length:	1220	Identity:	530/1220 - (43%)
Similarity:	735/1220 - (60%)	Gaps:	169/1220 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NRFQVNPVNGNSRKSQGADGPGSGSGAGAGAGAGAGEDGPHEVYRRLTNAEGELLEDDTFDATQM 82
            :||||:.:|               .|.|:||......|.||                  ::.|..
  Rat    15 SRFQVHVIN---------------EGHGSGAAMSDSTDPPH------------------YEETSF 46

  Fly    83 LNQRQPRQQRQSIKSSFRDKDKPSRFKDLQTTTRFQVDPQNEESDESNDSQEERELLDNEYDTKY 147
            .::.|.|     :|.|||..::......|||             .|:..:.......|:..:|.|
  Rat    47 GDEAQNR-----LKISFRPGNQECYENFLQT-------------GETAKTDTTFHAYDSHTNTYY 93

  Fly   148 GKSFRHFTREALPRLDNYRNMMSIQA--AYRPTLDELHNA----TLVGKNTHSLTRNQDPESG-- 204
            .::|.|.|.:|:|:::.|||..|:..  ..||:|.|:|..    ..|...:.....|.|...|
  Rat    94 LQTFGHNTMDAVPKIEYYRNTGSVSGPKVNRPSLQEIHEQLAKNVAVAPGSADRVANGDGMPGDE 158

  Fly   205 -------ILNGVLKFGWIKGVLVRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITA 262
                   .:.||:||||:|||||||:|||||||||:||||:||:||:..|.::||.:|.||:||.
  Rat   159 QAENKEEDVTGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITG 223

  Fly   263 LSMSAISTNGVIKGGGTYYMISRSLGPEFGGSIGLIFSLANAVACAMYVVGFCESMLAMMTTFGW 327
            ||.|||:|||.::|||.||:|||||||||||||||||:.|||||.|||||||.|:::.::.....
  Rat   224 LSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDS 288

  Fly   328 EIIDGGVQDVRIIGCITILLLLIIVVVGMEWEAKAQIGLLIILLVAIGDFVIGSFIGPKSDAEMA 392
            .::| ...|:||||.||:::||.|.|.|||||||||:.||:|||:||.:|.||:.| |.::.:.:
  Rat   289 MMVD-PTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVI-PSNNEKKS 351

  Fly   393 KGFLGYNATLFKNNLFADYRPEKGGIQHDFFSVFAIFFPAATGILAGANISGDLKDPQKSIPKGT 457
            :||..|.|::|..|....:...:|     |||||||||||||||||||||||||:|||.:||:||
  Rat   352 RGFFNYQASIFAENFGPSFTEGEG-----FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGT 411

  Fly   458 ILAIVITTGTYLIMVLQCGATVARDATGNLSDVV------NGTFA------FLDCQPGECNYGLQ 510
            :|||.|||..|:.:.:...|.|.|||||:::|.|      ||:.|      |..||...|.|||.
  Rat   412 MLAIFITTVAYIGVAICVAACVVRDATGSMNDTVVSGMNCNGSAACGLGYDFSRCQHEPCQYGLM 476

  Fly   511 NSFQVIELVSAFGPLIYAGCYAATLSSALASLVSAPKVFQALCKDELYPKIVWFAKGYGKNNEPV 575
            |:|||:.:||.|||||.||.::|||||||||||||||||||||||.::..:.:|||||||||||:
  Rat   477 NNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIFKGLQFFAKGYGKNNEPL 541

  Fly   576 RGYVLTFIIACAFILIGELNLIAPLISNFFLAAYMLINFSTFHASLAKPVGWRPTFKYYNMWLSL 640
            |||.|||:||.|||||.|||:|||:|||||||:|.|||||.||||.||..||||.:..||||:||
  Rat   542 RGYFLTFVIAMAFILIAELNVIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSL 606

  Fly   641 LGAILCVAVMFLISWATALITFAAVLALYLIVAYRKPDVNWGSTTQAQTYKNALMSVQQLNNVEE 705
            .|||||.||||:|:|..|:||:...|.||:.|.|:||||||||:|||.:|.:||.:..:|..||:
  Rat   607 FGAILCCAVMFVINWWAAVITYVIELFLYIYVTYKKPDVNWGSSTQALSYVSALDNALELTTVED 671

  Fly   706 HVKNYRPQILVLSGLPNTRPVLVDLAYMLTKNLSLLVCGHVLKGSSS---QKYRTYLQERAGNWF 767
            ||||:|||.:||:|.|.|||.|:|:.:..|||..|.:|..|..|...   ::..:.:.::.. |.
  Rat   672 HVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQA-WL 735

  Fly   768 RKHRVKGFYALVDGEDFESGTRALMQATGIGKLKPNIILMGYKTDWQTCDHKELDQYFNVMHKAL 832
            .|:::|.|||.|..:.|..|.|:|:||:|:|::|||.:::|||.:|:.....||:.|..::|.|.
  Rat   736 MKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLSELENYVGIIHDAF 800

  Fly   833 DMYLSVAILRVPQGLDCSQVLGSQDGWKTVSDVPRTLQPNESSGDLQAVDSSVRNGLSGSIDSLS 897
            |..:.|.|:|:.||.|.|.||..||                   :|:.::.. |..|..:|..
  Rat   801 DFEIGVVIVRISQGFDISPVLQVQD-------------------ELEKLEQE-RLALEAAIKD-- 843

  Fly   898 RNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGNQSKDVSGMPDP 962
             |..:|.                     |.|:|.:....|..:.|.                  |
  Rat   844 -NDCEEG---------------------KGGIRGLFKKAGKLNITK------------------P 868

  Fly   963 LDAKSANLVSNSLRKSKLKHDDPASLYKGPGGAELPKEVLADLTQFTRKRSHAVIDVWWLYDDGG 1027
            ...|.:|:       |.::     |::.|    |..::::....||.:|:....||||||:||||
  Rat   869 APKKDSNI-------STIQ-----SMHVG----EFNQKLVEASAQFKKKQGKGTIDVWWLFDDGG 917

  Fly  1028 LTLLLPYIISTRRTWQSCKLRVYALANKNSELEFEQRSMASLLSKFRIDYSDLTLIPDITKKPQE 1092
            ||||:|||::.|:.|:.||||:| :..|.:.:|.|:.|||||||||||.::|:.:|.||..||.:
  Rat   918 LTLLIPYILTLRKKWKDCKLRIY-VGGKINRIEEEKISMASLLSKFRIKFADIHIIGDINIKPNK 981

  Fly  1093 TSTQFFNELIKDFVVTEKDGENGTSSRATLNEDDALITDDDLLAVQDKTNRYLRLREYLREQSTK 1157
            .|.:.|.|:|:.:.:.|.. ::.|::.....|....|||.:|.||::|:.|.:||.|.|:|.|..
  Rat   982 ESWKVFEEMIEPYRLHESH-KDLTTAEKLKRESPWKITDAELEAVKEKSYRQVRLNELLQEHSRA 1045

  Fly  1158 SDLVVMTLPMPRKNIVSAPLYMAWLESLSRDMPPFLFVRGNQTSVLTFYS 1207
            ::|:|::||:.||..:|..|||||||.|::::||.|.||||..:||||||
  Rat  1046 ANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588	15/40 (38%)
		2a30	155..1207	CDD:273347	500/1081 (46%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	111/157 (71%)
		SLC12	724..1207	CDD:281515	162/485 (33%)
Slc12a1	NP_001257546.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..45		6/36 (17%)
		AA_permease_N	86..152	CDD:285588	19/65 (29%)
		2a30	100..1095	CDD:273347	500/1082 (46%)
		SLC12	690..1095	CDD:281515	162/485 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352211
Domainoid	1	1.000	629	1.000	Domainoid score	I166
eggNOG	1	0.900	-	-		E2759_KOG2083
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	993	1.000	Inparanoid score	I287
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D135130at33208
OrthoFinder	1	1.000	-	-		FOG0001536
OrthoInspector	1	1.000	-	-		mtm8955
orthoMCL	1	0.900	-	-		OOG6_101360
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X709
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770