Protein Alignment Ncc69 and Slc12a7

DIOPT Version :10

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: XP_006517233.1
• Gene: Slc12a7 / 20499
• MGIID: 1342283
• Length: 1117
• Species: Mus musculus
• Alignment Length: 1352
• Identity: 338/1352 - (25%)
• Similarity: 532/1352 - (39%)
• Gaps: 436/1352 - (32%)

  Fly    48 AGAGAGEDGPHEVYRRLTNAEG---ELLEDDTFDATQMLNQRQPRQQRQSIKSSFRDKD------ 103
            |.:|.|:.|        |.|||   .|..|.  |....|:.........::|  .::.|
Mouse    10 AQSGTGDAG--------TRAEGGNQRLCSDS--DPDPDLDPNPDPSLAAALK--IQEVDALPILR 62

  Fly   104 ---KPSRFKDLQTTTRFQVDPQNEESDESNDSQEERE---------LLDNEYDTKYGKSFRHFTR 156
               :|||:.|        .:|: |.|...|:.:.|||         |.:.|.|:      .....
Mouse    63 YCREPSRYGD--------GNPR-ENSPFINNVEVERESYFEGKNMALFEEEMDS------NPMVS 112

  Fly   157 EALPRLDNYRNMMSIQAAYRPTLDELHNATLVGKNTHSLTRNQDPESGILNGVL--KFGWIKGVL 219
            ..|.:|.||.|:                       :..:..:::.|......|.  :.|...||.
Mouse   113 SLLNKLANYTNL-----------------------SQGVVEHEEDEDSRRREVKAPRMGTFIGVY 154

  Fly   220 VRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMIS 284
            :.||.||.||:|||||:|:||.|||:|.|:::......|.:||:|||||:||||:..||:|||||
Mouse   155 LPCLQNILGVILFLRLTWIVGAAGVMESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMIS 219

  Fly   285 RSLGPEFGGSIGLIFSLANAVACAMYVVGFCESMLAMMT----TFGWEIIDGG----VQDVRIIG 341
            |||||||||::||.|.|....|.|||::|..|..|..::    .|..|..||.    :.::|:.|
Mouse   220 RSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPSAAIFQAETADGEAAALLNNMRVYG 284

  Fly   342 CITILLLLIIVVVGMEWEAKAQIGLLIILLVAI----------------------GD-------- 376
            ...:.|:.::|.||:::..|..:..|..::::|                      |:
Mouse   285 SCALALMAVVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKTAFAPPDIPVCLLGNRTLANRNF 349

  Fly   377 ---------------------FVIGSFIGPKSDAEMA-------KGFLGYNATLFKNNLFADY-- 411
                                 |..||.:|...|...|       :|..|..:.:|.:||::.|
Mouse   350 DTCAKMQVVSNGTVTTALWRLFCNGSSLGATCDEYFAQNNVTEIQGIPGVASGVFLDNLWSTYSD 414

  Fly   412 -------------------RPEKGGIQH---DFFSVF----AIFFPAATGILAGANISGDLKDPQ 450
                               ||  ||:.:   |..:.|    .|:||:.|||:||:|.||||||.|
Mouse   415 KGAFVEKKGVSSVPVSEESRP--GGLPYVLTDIMTYFTMLVGIYFPSVTGIMAGSNRSGDLKDAQ 477

  Fly   451 KSIPKGTILAIVITTGTYLIMVLQCGA----TVARDATGNLSDVVNGTFAFLDCQPGECNYGLQN 511
            ||||.|||||||.|:..||..::..||    .|.||..|.                     .||.
Mouse   478 KSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGE---------------------ALQG 521

  Fly   512 SFQVIELVSAFGP-LIYAGCYAATLSSALASLVSAPKVFQALCKDELYPKIVWFAKGYGK-NNEP 574
            :. ||.:::...| :|..|.:.:|..:.|.||..||::.||:.:|.:.|.:..|  |:|| |.||
Mouse   522 NL-VIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIIPFLQVF--GHGKANGEP 583

  Fly   575 VRGYVLTFIIACAFILIGELNLIAPLISNFFLAAYMLINFSTFHASLAKPVGWRPTFKYYNMWLS 639
            ....:||.:|....|||..|:.:||::|.|||..||.:|.:....:|.:...|||.||:|:..||
Mouse   584 TWALLLTALICETGILIASLDSVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFKFYHWTLS 648

  Fly   640 LLGAILCVAVMFLISWATALITFAAVLA--LYLIVAYRKPDVNWGSTTQAQTYKNALMSVQQLNN 702
            .||..||:|:||:.||..||  ||.::|  :|..:.||..:..||...:..:...|..::.::.:
Mouse   649 FLGMSLCLALMFICSWYYAL--FAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEH 711

  Fly   703 VEEHVKNYRPQILVLSGLPNTR----PVLVDLAYMLTKNLSLLVCGHVLKGSSSQKYRTYL---- 759
            ...|.||:|||:||:..|.:.:    |.|:.....|.....|.:.|.||:|       |||
Mouse   712 GPPHTKNWRPQVLVMLNLDSEQCVKHPRLLSFTSQLKAGKGLTIVGSVLEG-------TYLDKHV 769

  Fly   760 -----QERAGNWFRKHRVKGFYALVDGEDFESGTRALMQATGIGKLKPNIILMGYKTDWQTCDHK 819
                 :|...:.....:.|||..||...:...|...|:|:.|:|.:|.|.:||.:...|     |
Mouse   770 EAQRAEENIRSLMSAEKTKGFCQLVVSSNLRDGASHLIQSAGLGGMKHNTVLMAWPEAW-----K 829

  Fly   820 ELDQYFNVMHKALDMYLSVAILRVPQGLDCSQVLGSQDGWKTVSDVPRTLQPNESSGDLQAVDSS 884
            |.|..|:                                ||...|..|
Mouse   830 EADNPFS--------------------------------WKNFVDTVR----------------- 845

  Fly   885 VRNGLSGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIA 949
                                                                             
Mouse   846 ----------------------------------------------------------------- 845

  Fly   950 GNQSKDVSGMPDPLDAKSANLVSNSLRKSKLKHDDPASLYKGPGGAELPKEVLADLTQFTRKR-S 1013
                       |...|..|.||:.::                            ||....::| |
Mouse   846 -----------DTTAAHQALLVAKNI----------------------------DLFPQNQERFS 871

  Fly  1014 HAVIDVWWLYDDGGLTLLLPYIISTRRTWQSCKLRVYALANKNSELEFEQRSMASLLSKFRIDYS 1078
            ...|||||:..|||:.:|||:::...:.|:.|::|::.:|..:......::.:...|...||. :
Mouse   872 DGNIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRIS-A 935

  Fly  1079 DLTLIP----DITKKPQETSTQF--FNELIKDFVVTEKDGE--------NGTSSRATL------- 1122
            ::.::.    ||:....|.:...  .::::|...:::.:.|        ..|:|..|.
Mouse   936 EVEVVEMVENDISAFTYEKTLMMEQRSQMLKQMQLSKNEREREAQLIHDRNTASHTTATARTQAP 1000

  Fly  1123 ---------------------NEDDALITDDDLLAVQ------DKTN-----RYLRLREYLREQS 1155
                                 |:|.......||.:::      |::|     ..::|...:..:|
Mouse  1001 PTPDKVQMTWTKEKLIAEKHRNKDTGPSGFKDLFSLKPEWGNLDQSNVRRMHTAVKLNGVVLNKS 1065

  Fly  1156 TKSDLVVMTLPMPRKNIVSAPLYMAWLESLSRDMPPFLFVRGNQTSVLTFYS 1207
            ..:.||::.:|.|.|:......||.:||.|:..:...|.|||....|:|.||
Mouse  1066 QDAQLVLLNMPGPPKSRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_2	155..1207	CDD:459263	308/1222 (25%)
Slc12a7	XP_006517233.1	AA_permease_2	74..1117	CDD:459263	318/1266 (25%)