Protein Alignment Ncc69 and Slc12a3

DIOPT Version :10

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: XP_017168114.1
• Gene: Slc12a3 / 20497
• MGIID: 108114
• Length: 1009
• Species: Mus musculus
• Alignment Length: 1122
• Identity: 445/1122 - (39%)
• Similarity: 640/1122 - (57%)
• Gaps: 196/1122 - (17%)

  Fly   131 DSQEERELLDNEYDTKYGKSFRHFTREALPRLDNYRN--MMSIQAAYRPTLDELHN-ATLVGKNT 192
            ||.:...|...  .|.|.::|.:.|.:.:|..::|.|  :.......||||.:||: ....|.:.
Mouse    36 DSSQPSHLTHG--STLYMRTFGYNTIDVVPAYEHYANSALPGEPRKVRPTLADLHSFLKQEGSHL 98

  Fly   193 HSLTRNQDPESGILNGV----------------LKFGWIKGVLVRCLLNIWGVMLFLRLSWVVGQ 241
            |:|..:......:.:|:                ::|||:|||::||:||||||:|:|||.|:..|
Mouse    99 HALAFDGRQGRELTDGLVEDETGTNSEKSPGEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQ 163

  Fly   242 AGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMISRSLGPEFGGSIGLIFSLANAVA 306
            ||::..:::||.:..||:||.||:|||||||.:|.||||::||||||||.||||||||:.||||.
Mouse   164 AGIVLTWLIILLSVMVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVG 228

  Fly   307 CAMYVVGFCESM-----LAMMTT--FGWEIIDGGVQDVRIIGCITILLLLIIVVVGMEWEAKAQI 364
            .||:.|||.|::     ||...|  :|..|:| .:.|:||||.:|:.:||.|.:.|||||:|||:
Mouse   229 VAMHTVGFAETVRDLLQLACSPTQEYGTPIVD-PINDIRIIGVVTVTVLLAISLAGMEWESKAQV 292

  Fly   365 GLLIILLVAIGDFVIGSFIGPKSDAEMAKGFLGYNATLFKNNLFADYRPEKGGIQHDFFSVFAIF 429
            ...::::|:..::::|:.| |.|:.:.:|||..|:..:|..||..|:|    ||...||.:|:||
Mouse   293 LFFLVIMVSFANYLVGTLI-PASEDKASKGFYSYHGDIFVQNLVPDWR----GIDGSFFGMFSIF 352

  Fly   430 FPAATGILAGANISGDLKDPQKSIPKGTILAIVITTGTYLIMVLQCGATVARDATGNLSDVVNG- 493
            ||:|||||||||||||||||..:|||||::||..||.:||.:....|:.|.|||:|:::|.:..
Mouse   353 FPSATGILAGANISGDLKDPAVAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGDVNDTMTPG 417

  Fly   494 -----------TFAFLDC-QPGECNYGLQNSFQVIELVSAFGPLIYAGCYAATLSSALASLVSAP 546
                       .:.|.:| |...|.|||.|.:|.:.:||||.|||.||.:.||||||||.||||.
Mouse   418 PGPCEGLACGYGWNFTECSQQRSCRYGLINYYQTMSMVSAFAPLITAGIFGATLSSALACLVSAA 482

  Fly   547 KVFQALCKDELYPKIVWFAKGYGKNNEPVRGYVLTFIIACAFILIGELNLIAPLISNFFLAAYML 611
            ||||.||:|:|||.|.:|.||||||.||||||:|.:.||.|||:|.|||.|||:||||||.:|.|
Mouse   483 KVFQCLCEDQLYPLIGFFGKGYGKNREPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYAL 547

  Fly   612 INFSTFHASLAKPVGWRPTFKYYNMWLSLLGAILCVAVMFLISWATALITFAAVLALYLIVAYRK 676
            ||||.||||:....||||:|:||:.|.:|.||::.|.:|||::|..|||....||.|.|.|.|:|
Mouse   548 INFSCFHASITNSPGWRPSFRYYSKWAALFGAVISVVIMFLLTWWAALIAIGVVLFLLLYVIYKK 612

  Fly   677 PDVNWGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQILVLSGLPNTRPVLVDLAYMLTKNLSLL 741
            |:|||||:.||.:|..||.....||.||:|:||||||.|||:|.||.||.|||.....|:||||:
Mouse   613 PEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVSTFTQNLSLM 677

  Fly   742 VCGHVLKGSSSQKYRTYLQERAGN--WFRKHRVKGFYALVDGEDFESGTRALMQATGIGKLKPNI 804
            :|||||.|...|:........:|:  |..|.::|.||:.|..||..||.:.||||:|:|::||||
Mouse   678 ICGHVLIGPGKQRVPELRLIASGHTKWLNKRKIKAFYSDVIAEDLRSGVQILMQASGLGRMKPNI 742

  Fly   805 ILMGYKTDWQTCDHKELDQYFNVMHKALDMYLSVAILRVPQGLDCSQVLGSQDGWKTVSDVPRTL 869
            :::|:|.:||:.....::.|..|:|.|.|....|.::|:.:||:.|:.|
Mouse   743 LVVGFKRNWQSAHPATVEDYIGVLHDAFDFNYGVCVMRMREGLNVSEAL---------------- 791

  Fly   870 QPNESSGDLQAVDSSVRNGLSGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRS 934
                                            |.......|:..||.|
Mouse   792 --------------------------------QTHTTPEALIQEEQAS----------------- 807

  Fly   935 WPGAASSTSDLSFIAGNQSKDVSGMPDPLDAKSANLVSNSLRKSKLKHDDPASLYKGPGGAELPK 999
                                                                             
Mouse   808 ----------------------------------------------------------------- 807

  Fly  1000 EVLADLTQFTRKRSHAVIDVWWLYDDGGLTLLLPYIISTRRTWQSCKLRVYALANKNSELEFEQR 1064
                  |.|..::....||::||:||||||||:||::..::.|..||:||: :..:.:.::.|::
Mouse   808 ------TIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLHRKKRWGKCKIRVF-VGGQINRMDEERK 865

  Fly  1065 SMASLLSKFRIDYSDLTLIPDITKKPQETSTQFFNELIKDFVVTEKDGENGTSSRATLNE--DDA 1127
            ::.|||||||:.:.::.::|||.:|||...|:.|.::|..|.:.:     |....||:.|  .|.
Mouse   866 AIISLLSKFRLGFHEVHVLPDINQKPQAEHTKRFEDMIAPFRLND-----GFKDEATVTEMRRDC 925

  Fly  1128 --LITDDDLLAVQDKTNRYLRLREYLREQSTKSDLVVMTLPMPRKNIVSAPLYMAWLESLSRDM- 1189
              .|:|:::...:.|:.|.:||.|.|.:.|..:.|:::|||:.||....:.|||||||:||:|:
Mouse   926 PWKISDEEINKNRIKSLRQVRLSEILLDYSRDAALIILTLPIGRKGKCPSSLYMAWLETLSQDLR 990

  Fly  1190 PPFLFVRGNQTSVLTFY 1206
            ||.|.:||||.:|||||
Mouse   991 PPVLLIRGNQENVLTFY 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_2	155..1207	CDD:459263	439/1098 (40%)
Slc12a3	XP_017168114.1	2a30	57..1008	CDD:273347	439/1099 (40%)