DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ncc69 and Slc12a2

DIOPT Version :9

Sequence 1:NP_001261758.1 Gene:Ncc69 / 39410 FlyBaseID:FBgn0036279 Length:1207 Species:Drosophila melanogaster
Sequence 2:NP_033220.2 Gene:Slc12a2 / 20496 MGIID:101924 Length:1206 Species:Mus musculus


Alignment Length:1265 Identity:561/1265 - (44%)
Similarity:764/1265 - (60%) Gaps:188/1265 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 GSAADRP------PNRFQVNPVNGNSRKSQGADGPGSGSGAGAG--------AGAGAGEDGPHEV 60
            |....||      .:||||:||:.|:.::..|....:.:.|.||        ||...||.|   |
Mouse    63 GDGLGRPLGPTPSQSRFQVDPVSENAGRAAAAAAAAAAAAAAAGAAGKETPAAGKAGGESG---V 124

  Fly    61 YRRLTNAEGELLEDDTFDATQMLNQRQPRQQRQSIKSSFRDK-----DKPSRFKDLQTTTRFQVD 120
            .:....|:|..          .:|...|... .|...|..|.     |.|:        ..||..
Mouse   125 AKGSEEAKGRF----------RVNFVDPAAS-SSADDSLSDAAGVGGDGPN--------VSFQNG 170

  Fly   121 PQNEESDESN------DSQEERELLDNEYDTKYGKSFRHFTREALPRLDNYRNMMSI--QAAYRP 177
            .....|:.|:      ....::...|...:|.|.::|.|.|.:|:||:|:||:..:.  :...||
Mouse   171 GDTVLSEGSSLHSGGGSGHHQQYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLRP 235

  Fly   178 TLDELHNATLVGKNTHSLTRNQDP-ESGILN-------------------GVLKFGWIKGVLVRC 222
            :|.|||:..           .::| |.|..|                   ||:||||||||||||
Mouse   236 SLAELHDEL-----------EKEPFEDGFANGEESTPTRDAVVAYTAESKGVVKFGWIKGVLVRC 289

  Fly   223 LLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMISRSL 287
            :|||||||||:||||:|||||:....|:|...|.|||||.||.|||:|||.::|||.||:|||||
Mouse   290 MLNIWGVMLFIRLSWIVGQAGIGLSVVVIAMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSL 354

  Fly   288 GPEFGGSIGLIFSLANAVACAMYVVGFCESMLAMMTTFGWEIIDGGVQDVRIIGCITILLLLIIV 352
            ||||||:|||||:.|||||.|||||||.|:::.::......:|| .:.|:||||.||:::||.|.
Mouse   355 GPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMID-EINDIRIIGAITVVILLGIS 418

  Fly   353 VVGMEWEAKAQIGLLIILLVAIGDFVIGSFIGPKSDAEMAKGFLGYNATLFKNNLFADYRPEKGG 417
            |.||||||||||.||:|||:||.|||||:||..:|  :..|||.||.:.:|..|...|:|.|:  
Mouse   419 VAGMEWEAKAQIVLLVILLLAIADFVIGTFISLES--KKPKGFFGYKSEIFNENFGPDFREEE-- 479

  Fly   418 IQHDFFSVFAIFFPAATGILAGANISGDLKDPQKSIPKGTILAIVITTGTYLIMVLQCGATVARD 482
               .|||||||||||||||||||||||||.|||.:|||||:|||:|||..|:.:.:..|:.|.||
Mouse   480 ---TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTVVYIGIAVSVGSCVVRD 541

  Fly   483 ATGNLSDVV-----NGT-------FAFLDCQPGECNYGLQNSFQVIELVSAFGPLIYAGCYAATL 535
            ||||::|.:     |.|       |.|..|:...|:|||.|:|||:.:||.|.|||.||.::|||
Mouse   542 ATGNVNDTITTELTNCTSAACKLNFDFSYCESNTCSYGLMNNFQVMSMVSGFAPLISAGIFSATL 606

  Fly   536 SSALASLVSAPKVFQALCKDELYPKIVWFAKGYGKNNEPVRGYVLTFIIACAFILIGELNLIAPL 600
            ||||||||||||:|||||||.:||....|||||||||||:|||:|||:||..||||.|||:|||:
Mouse   607 SSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPI 671

  Fly   601 ISNFFLAAYMLINFSTFHASLAKPVGWRPTFKYYNMWLSLLGAILCVAVMFLISWATALITFAAV 665
            |||||||:|.|||||.|||||||..||||.|||||||:||:|||||..|||:|:|..||:|:..|
Mouse   672 ISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLIGAILCCIVMFVINWWAALLTYVIV 736

  Fly   666 LALYLIVAYRKPDVNWGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQILVLSGLPNTRPVLVDL 730
            |.||:.|.|:||||||||:|||.||.:||....:|:.||:||||:|||.||::|.||:||.|:.|
Mouse   737 LGLYIYVTYKKPDVNWGSSTQALTYLSALQHSIRLSGVEDHVKNFRPQCLVMTGSPNSRPALLHL 801

  Fly   731 AYMLTKNLSLLVCGHVLKGSSSQ--KYRTYLQERAGNWFRKHRVKGFYALVDGEDFESGTRALMQ 793
            .:..|||:.|::||||..|...|  |..:..|.|...|..|:::|.|||.|..:|...|.:.|||
Mouse   802 VHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQARYQRWLIKNKMKAFYAPVHADDLREGAQYLMQ 866

  Fly   794 ATGIGKLKPNIILMGYKTDWQTCDHKELDQYFNVMHKALDMYLSVAILRVPQGLDCSQVLGSQDG 858
            |.|:|::|||.:::|:|.||...|.:::|.|.|:.|.|.|:...|.::|:.:|||.|.:.|.:: 
Mouse   867 AAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQFGVVVIRLKEGLDISHLQGQEE- 930

  Fly   859 WKTVSDVPRTLQPNESSGDLQAVDSSVRNGLSGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKL 923
                     .|...|.|              .|:.|.:. ||....:       |:|::.|    
Mouse   931 ---------LLSSQEKS--------------PGTKDVVV-NVDYSKK-------SDQDTCK---- 960

  Fly   924 RFKQGLRRMRSWPGAASSTSDLSFIAGNQSKDVSGMPDPLDAKSANLVSNSLRKSKLKHDDPASL 988
                             |:.:.|....::.:|......||           |:|..         
Mouse   961 -----------------SSGEKSITQKDEEEDGKTPTQPL-----------LKKES--------- 988

  Fly   989 YKGPGGAELP-----KEVLADLTQFTRKRSHAVIDVWWLYDDGGLTLLLPYIISTRRTWQSCKLR 1048
             |||   .:|     :::|...|||.:|:....||||||:||||||||:||:::|::.|:.||:|
Mouse   989 -KGP---IVPLNVADQKLLEASTQFQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIR 1049

  Fly  1049 VYALANKNSELEFEQRSMASLLSKFRIDYSDLTLIPDITKKPQETSTQFFNELIKDFVVTEKDGE 1113
            |: :..|.:.::.::|:||:||||||||:||:.::.||..||::.:...|:::|:.:.:.|.|.|
Mouse  1050 VF-IGGKINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENIIAFDDMIEPYRLHEDDKE 1113

  Fly  1114 NGTSSRATLNEDDA-LITDDDLLAVQDKTNRYLRLREYLREQSTKSDLVVMTLPMPRKNIVSAPL 1177
            ...:.:  :.||:. .|||::|...:.||.|.:||.|.|:|.|:.::::||:||:.||..||:.|
Mouse  1114 QDIADK--MKEDEPWRITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSAL 1176

  Fly  1178 YMAWLESLSRDMPPFLFVRGNQTSVLTFYS 1207
            ||||||:||:|:||.|.||||..|||||||
Mouse  1177 YMAWLEALSKDLPPVLLVRGNHQSVLTFYS 1206

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ncc69NP_001261758.1 AA_permease_N 144..>183 CDD:285588 15/40 (38%)
2a30 155..1207 CDD:273347 521/1093 (48%)
ArsB_NhaD_permease <524..>682 CDD:304373 115/157 (73%)
SLC12 724..1207 CDD:281515 169/490 (34%)
Slc12a2NP_033220.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 144..188 9/52 (17%)
AA_permease_N 196..257 CDD:285588 22/71 (31%)
2a30 210..1206 CDD:273347 521/1094 (48%)
SLC12 795..1206 CDD:281515 169/490 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 954..987 9/64 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167848610
Domainoid 1 1.000 626 1.000 Domainoid score I175
eggNOG 1 0.900 - - E2759_KOG2083
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20283
Inparanoid 1 1.050 995 1.000 Inparanoid score I302
Isobase 1 0.950 - 0 Normalized mean entropy S2360
OMA 1 1.010 - - QHG57166
OrthoDB 1 1.010 - - D135130at33208
OrthoFinder 1 1.000 - - FOG0001536
OrthoInspector 1 1.000 - - mtm8718
orthoMCL 1 0.900 - - OOG6_101360
Panther 1 1.100 - - LDO PTHR11827
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5652
SonicParanoid 1 1.000 - - X709
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1716.750

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