Protein Alignment Ncc69 and kcc-2

DIOPT Version :10

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: NP_001255279.2
• Gene: kcc-2 / 177370
• WormBaseID: WBGene00019205
• Length: 1129
• Species: Caenorhabditis elegans
• Alignment Length: 1394
• Identity: 322/1394 - (23%)
• Similarity: 537/1394 - (38%)
• Gaps: 474/1394 - (34%)

  Fly    19 RFQVNPVNGNSRKSQGADGPGSGSGAGAGAGAGAGEDGPHEVYRRLTNAEGELLEDDTFDATQML 83
            ||:|..|         |||.|.|:|:     .||                    .|...|:...:
 Worm     5 RFRVQSV---------ADGGGGGAGS-----VGA--------------------LDSVSDSNLAV 35

  Fly    84 NQRQPRQQRQSIKSSFRD-KDKPSRFKDLQTTTRFQVD-------------PQNEESDESNDSQE 134
            |.    ..::.|.:...| :.:|:......|.|..:..             |.|...:...|...
 Worm    36 NS----ATKKEITNKAHDFEPEPTSSTSTNTVTSRRSSGGSGSGLGPASKKPPNMHINIPTDEGA 96

  Fly   135 ER----------ELLDNEYDT---KYGKSFRHFTREALPRLDNYRNMMSIQAAYRPTLDELHNAT 186
            ||          .|.:.:|||   |.|...|..:                          ::|||
 Worm    97 ERIPLCEQHSPLALYEQDYDTQGQKIGTMLRKLS--------------------------VYNAT 135

  Fly   187 LVGKNTHSLTRNQDPESGILNGVLKFGWIKGVLVRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLI 251
                ...|:..::.|::    ...|.|.|.||.:.||.||:||:.|:||:|::|.|||.:.|.::
 Worm   136 ----EATSVEADEKPKA----AAAKMGTIMGVFLPCLQNIFGVLFFIRLAWIIGTAGVFQAFFVV 192

  Fly   252 LTTTAVTTITALSMSAISTNGVIKGGGTYYMISRSLGPEFGGSIGLIFSLANAVACAMYVVGFCE 316
            ||..:||.:|::|:|||:||||:..||.||||||:||||.||::|::|.|...:|.:||:.|..|
 Worm   193 LTCVSVTFLTSISLSAIATNGVVPSGGPYYMISRNLGPELGGAVGILFYLGTTIAASMYITGAIE 257

  Fly   317 SMLAMMTTFGWEIIDGGVQDVRIIGCITILLLLIIVVVGMEWEAKAQIGLLIILLVAIGDFVIGS 381
            .:|..:.... ::.|....:.|::|.:.:|:|.:||:.|:::..:..:.|:|::::.|...::|.
 Worm   258 ILLLYIYPQA-KLFDDIYHNFRVLGTVLLLILGLIVMAGVKFVNRCALPLVIVVILCILSAILGV 321

  Fly   382 F-----------------------------IGPKSDAE-MAKGFLGYNAT--------------- 401
            |                             :.|...|: :...|...|.|
 Worm   322 FVRYDGSDSLKFCMVGDRPVDLSTYFEKTQVQPNCTADGLQDLFCSTNGTCDHYYDRMKNIKVWK 386

  Fly   402 -------------------LFKNNLFADY----------RPEKGGIQH-------------DFFS 424
                               :|.:||:..|          |.:||.:..             :|..
 Worm   387 SSGMPAIREERAIKGIASGVFFDNLWPKYLRAGEVLSKDRKDKGDLNRGGHPSYIYAESVTNFMI 451

  Fly   425 VFAIFFPAATGILAGANISGDLKDPQKSIPKGTILAIVITTGTYLIMVLQCGATVA--------- 480
            :..:|||:||||:||:|.||:|:|..||||.||:.|...::..||:.|:..||:|:
 Worm   452 LVGVFFPSATGIMAGSNRSGNLRDAAKSIPLGTLAAQNFSSFIYLLGVVLFGASVSEMFIRDKYG 516

  Fly   481 RDATGNLSDVVNGTFAFLDCQPGECNYGLQNSFQVIELVSAFGPLIYAGCYAATLSSALASLVSA 545
            |.|.|.|.                          :.|:...|..:|..||:.:|..:.:.||..|
 Worm   517 RSAMGKLI--------------------------ISEISWPFPQVILFGCFMSTAGAGMQSLTGA 555

  Fly   546 PKVFQALCKDELYPKIVWFAKGYGK---NNEPVRGYVLTFIIACAFILIGELNLIAPLISNFFLA 607
            |::.||:..|::.|    |.|.:.|   ..||:|..:||..|....|||..:..|..||:.|||.
 Worm   556 PRLLQAIAADDVLP----FLKPFRKMDSRGEPIRAILLTLAICECGILIAVIENITALITQFFLM 616

  Fly   608 AYMLINFSTFHASLAKPVGWRPTFKYYNMWLSLLGAILCVAVMFLISWATALITFAAVLALYLIV 672
            .|:.:|.:....||.|..||||.|:|::..||::||||||||||:.:|..||........:|..:
 Worm   617 CYLGVNAACALQSLLKSPGWRPGFRYFHWSLSMIGAILCVAVMFISAWHFALFAIIIGAGVYKYI 681

  Fly   673 AYRKPDVNWGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQILVLSGLP-----NTRPVLVDLAY 732
            .|...:..||...:......|..::..|::..:|.:|:|||:|||:  |     ||..:| ....
 Worm   682 EYAGAEKEWGDGLRGLGLSAARFALLNLDDKPQHSRNWRPQLLVLA--PDVESANTNGIL-SFVS 743

  Fly   733 MLTKNLSLLVCGHVLKGSSSQKY--RTYLQERAGNWFRKHRVKGFYALVDGEDFESGTRALMQAT 795
            .|.....|.:..|.::|..:..|  ...:||:.....:|:::|||..::...:...|...|:|.:
 Worm   744 QLKAGKGLTLVAHCMEGEYADNYLKAQAVQEKLKAVVKKNKIKGFCDVLVTSNVIEGISCLVQTS 808

  Fly   796 GIGKLKPNIILMGYKTDWQTCDHKELDQYFNVMHKALDMYLSVAILRVPQGLDCSQVLGSQDGWK 860
            |:|.::.|.:::.:..||:                                        ::..|
 Worm   809 GLGGMRHNTVVLSWPNDWK----------------------------------------AEQEW- 832

  Fly   861 TVSDVPRTLQPNESSGDLQAVDSSVRNGLSGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRF 925
                                                                       :|..:|
 Worm   833 -----------------------------------------------------------VVANKF 838

  Fly   926 KQGLRRMRSWPGAASSTSDLSFIAGNQSKDVSGMPDPLDAKSANLVSNSLRKSKLKHDDPASLYK 990
            ...:|.:.:                              ||.|.:|.....|.      ||:..|
 Worm   839 VSAIRAISA------------------------------AKCAIMVPKYAEKF------PANGTK 867

  Fly   991 GPGGAELPKEVLADLTQFTRKRSHAVIDVWWLYDDGGLTLLLPYIISTRRTWQSCKLRVYALANK 1055
            ..|                      .|||||:..||||.:|||:::...:||::..:|::|:|
 Worm   868 VSG----------------------FIDVWWVVHDGGLLMLLPFLLRQHKTWKNTTVRLFAIA-- 908

  Fly  1056 NSELEFEQRSMASLLSKF----RI------------DYSDLT------------LIPDITKKPQE 1092
              ::|.....|.:.|.||    ||            |.||.|            .:.::.|..::
 Worm   909 --QMEDNNVQMKTDLEKFLYHLRIDAAVNVIEMTDSDISDYTYERTMKMEERNQYLKNLNKSDRD 971

  Fly  1093 TSTQFFNELI--------------------KDFVVTEKDGENGTSSR--ATLNEDDALITDD-DL 1134
            ...|...|::                    ::..|.:::.|:|.|..  |.:.......:|| |.
 Worm   972 KDIQNHLEIVTRERKLSRINEEAPAVVPEQRNLEVVDEEQEDGKSENGSAKIEHKGVRFSDDEDS 1036

  Fly  1135 LAV-------------QDKTNRY--------LRLREYLREQSTKSDLVVMTLPMPRKNIVSAPLY 1178
            ..|             :.:..||        ::|.|.:|::|:.:.||.:.||.| .:..|...|
 Worm  1037 KEVKVGNGTLERDREERQRKRRYNVHKMHTAVKLNELMRQKSSDAQLVFVNLPGP-PDADSDSYY 1100

  Fly  1179 MAWLESLSRDMPPFLFVRGNQTSVLTFYS 1207
            |.::|:|:..:...|.|||....|:|.||
 Worm  1101 MDFIEALTEGLDRVLLVRGTGAEVVTIYS 1129

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_2	155..1207	CDD:459263	288/1229 (23%)
kcc-2	NP_001255279.2	AA_permease_2	144..1129	CDD:459263	284/1185 (24%)