DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ncc69 and Slc12a5

DIOPT Version :9

Sequence 1:	NP_001261758.1	Gene:	Ncc69 / 39410	FlyBaseID:	FBgn0036279	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_001380604.1	Gene:	Slc12a5 / 171373	RGDID:	620811	Length:	1139	Species:	Rattus norvegicus

Alignment Length:	1349	Identity:	337/1349 - (24%)
Similarity:	510/1349 - (37%)	Gaps:	459/1349 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 PRQQRQSIKSSFRDKDKPSRF--KDLQTTTRFQVDPQNEESD---ESNDSQEERE-------LLD 140
            |..:|.|:..       |.|.  :|::.      |...:||.   .|.|:::.||       |.:
  Rat    21 PESRRHSVAD-------PRRLPREDVKG------DGNPKESSPFINSTDTEKGREYDGRNMALFE 72

  Fly   141 NEYDTKYGKSFRHFTREALPRLDNYRNMMSIQAAYRPTLDELHNATLVGKNTHSLTRNQDPESGI 205
            .|.||.      ......|..|.||.|:..                  |...|....|.  |.|.
  Rat    73 EEMDTS------PMVSSLLSGLANYTNLPQ------------------GSKEHEEAENN--EGGK 111

  Fly   206 LNGVL--KFGWIKGVLVRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAI 268
            ...|.  :.|...||.:.||.||:||:|||||:||||.||::|.|.::....:.|.:||:|||||
  Rat   112 KKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAI 176

  Fly   269 STNGVIKGGGTYYMISRSLGPEFGGSIGLIFSLANAVACAMYVVGFCESMLA----MMTTFGWEI 329
            :||||:..||:||||||||||||||::||.|.|....|.|||::|..|.:||    .|..|..|.
  Rat   177 ATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAED 241

  Fly   330 IDGG----VQDVRIIGCITILLLLIIVVVGMEWEAK---AQIGLLIILLVAIGDFVIGSFIGP-- 385
            ..|.    :.::|:.|...:..:..:|.||:::..|   ..:|.:|:.::||...||.|...|
  Rat   242 ASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPN 306

  Fly   386 -----------------------------------------------------KSDAEMAKGFLG 397
                                                                 :::....:|..|
  Rat   307 FPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRLLNATCDEYFTRNNVTEIQGIPG 371

  Fly   398 YNATLFKNNLFADY-----------RPEKG-------GIQH-----DFFSVF----AIFFPAATG 435
            ..:.|.|.||::.|           .|..|       .:.|     |..|.|    .|:||:.||
  Rat   372 AASGLIKENLWSSYLTKGVIVERRGMPSVGLADGTPVDMDHPYVFSDMTSYFTLLVGIYFPSVTG 436

  Fly   436 ILAGANISGDLKDPQKSIPKGTILAIVITTGTYLIMVLQCGA----TVARDATGNLSDVVNGTFA 496
            |:||:|.||||:|.|||||.||||||..|:..|:..|:..||    .|.||..|   :.|||..
  Rat   437 IMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFG---EAVNGNL- 497

  Fly   497 FLDCQPGECNYGLQNSFQVIELVSAFGP-LIYAGCYAATLSSALASLVSAPKVFQALCKDELYPK 560
                              |:..::...| :|..|.:.:|..:.|.||..||::.||:.:|.:.|.
  Rat   498 ------------------VVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPF 544

  Fly   561 IVWFAKGYGK-NNEPVRGYVLTFIIACAFILIGELNLIAPLISNFFLAAYMLINFSTFHASLAKP 624
            :..|  |:|| |.||....:||..|....|||..|:.:||::|.|||..||.:|.:....:|.:.
  Rat   545 LQVF--GHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRT 607

  Fly   625 VGWRPTFKYYNMWLSLLGAILCVAVMFLISWATALITFAAVLALYLIVAYRKPDVNWGSTTQAQT 689
            ..|||.|:||:..||.||..||:|:||:.||..||:.......:|..:.||..:..||...:..:
  Rat   608 PNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLS 672

  Fly   690 YKNALMSVQQLNNVEEHVKNYRPQILVLSGLPN----TRPVLVDLAYMLTKNLSLLVCGHVLKGS 750
            ...|..::.:|.....|.||:|||:|||..:..    ..|.|:.|...|.....|.:.|.||:|
  Rat   673 LSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEG- 736

  Fly   751 SSQKYRTYLQ-----ERAGNWFRK----HRVKGFYALVDGEDFESGTRALMQATGIGKLKPNIIL 806
                  |:|.     :||....|:    .:||||..:|...:...|...|:|:.|:|.|:.|.:|
  Rat   737 ------TFLDNHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVL 795

  Fly   807 MGYKTDW-QTCDHKELDQYFNVMHKALDMYLSVAILRVPQGLDCSQVLGSQDGWKTVSDVPRTLQ 870
            :|:..:| |..||:.                                      |:...::
  Rat   796 VGWPRNWRQKEDHQT--------------------------------------WRNFIEL----- 817

  Fly   871 PNESSGDLQAVDSSVRNGLSGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSW 935
                          ||...:|.:
  Rat   818 --------------VRETTAGHL------------------------------------------ 826

  Fly   936 PGAASSTSDLSFIAGNQSKDVSGMPDPLDAKSANLVSNSLRKSKLKHDDPASLYKGPGGAELPKE 1000
              |...|.::|...||..:...|.
  Rat   827 --ALLVTKNVSMFPGNPERFSEGS----------------------------------------- 848

  Fly  1001 VLADLTQFTRKRSHAVIDVWWLYDDGGLTLLLPYIISTRRTWQSCKLRVYALANKNSELEFEQRS 1065
                            |||||:..|||:.:|||:::...:.|:.||:|::.:|..:......::.
  Rat   849 ----------------IDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKD 897

  Fly  1066 MASLLSKFRI------------DYS----DLTLIPD----------ITKK--------------- 1089
            :.:.|...||            |.|    :.||:.:          :||.
  Rat   898 LTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRG 962

  Fly  1090 ----------------PQETSTQFFNE--------LIKDFVV-----------TEKDGENGT--- 1116
                            |:||:..  ||        ||.|...           .|.:||..|
  Rat   963 SIRRKNPANTRLRLNVPEETACD--NEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPE 1025

  Fly  1117 ---------SSRATLNEDDALITDD---DLLAV--------QDKTNRY---LRLREYLREQSTKS 1158
                     .|.|..|:..:.::.:   |..::        |....|.   :||.|.:..:|..:
  Rat  1026 KVHLTWTKDKSAAQKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVNKSRDA 1090

  Fly  1159 DLVVMTLPMPRKNIVSAPLYMAWLESLSRDMPPFLFVRGNQTSVLTFYS 1207
            .||::.:|.|.:|......||.:||.|:..:...:.|||....|:|.||
  Rat  1091 KLVLLNMPGPPRNRNGDENYMEFLEVLTEQLDRVMLVRGGGREVITIYS 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588	7/38 (18%)
		2a30	155..1207	CDD:273347	318/1268 (25%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	59/159 (37%)
		SLC12	724..1207	CDD:281515	104/594 (18%)
Slc12a5	NP_001380604.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62		11/53 (21%)
		2a30	44..1139	CDD:273347	328/1311 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..116		5/40 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	943..1025		14/83 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1033..1052		3/18 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352209
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850