DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ncc69 and Slc12a8

DIOPT Version :9

Sequence 1:	NP_001261758.1	Gene:	Ncc69 / 39410	FlyBaseID:	FBgn0036279	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_001357928.1	Gene:	Slc12a8 / 171286	MGIID:	2443672	Length:	705	Species:	Mus musculus

Alignment Length:	689	Identity:	177/689 - (25%)
Similarity:	284/689 - (41%)	Gaps:	222/689 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 FGWIKGVLVRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKG 276
            ||...||...|::||:||:||||..|:||..||:.|.:|:.....|..||.||...::.:|.|..
Mouse    38 FGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGLLLVSFVVLVALITVLSGIGVAEHGGISS 102

  Fly   277 GGTYYMISRSLGPEFGGSIGLIFSLANAVACAMYVVGFCESMLAMMTTFGWEIIDGGVQDVRIIG 341
            ||.|.|||..||.:.||::||::.....||.|||:.||.||:..::..       |.:..||.|.
Mouse   103 GGVYSMISSVLGGQMGGTVGLLYVFGQCVAGAMYITGFAESISDLLGL-------GDIWAVRGIS 160

  Fly   342 CITILLLLIIVVVGMEWEAKAQIGLLIILLVAIGDFVIGSFIGPKSDAEMAKGFLGYNATLFKNN 406
            ...:|.||.|.:.|::|..:.|:.||::|.|:..|||:|||    :..:...||:||:..|.::|
Mouse   161 VAVLLALLGINLAGVKWIIRLQLLLLLLLAVSTLDFVVGSF----THLDPEHGFIGYSPELLQSN 221

  Fly   407 LFADYRPEKGGIQHDFFSVFAIFFPAATGILAGANISGDLKDPQKSIPKGTILAIVITTGTYLIM 471
            :..:|.|.:     .||:||.:|||||||::||.|:.|||:||..|:|.|::.|:.::...|:|.
Mouse   222 ILPEYSPGE-----SFFTVFGVFFPAATGVMAGFNMGGDLRDPADSVPLGSLAAVGVSWFLYIIF 281

  Fly   472 VLQCGATVARDATGNLSDVVNGTFAFLDCQPGECNYGLQNSFQVIELVSAFGPLIYAGCYAATLS 536
            ....||...|:|                         |::.|.:.|.||..|.|...|.|.::|:
Mouse   282 AFLLGAVCTREA-------------------------LRSDFLIAEKVSLVGFLFLLGLYISSLA 321

  Fly   537 SALASLVSAPKVFQALCKDELYPKIVWFAKGYGKNNEPVRGYVLTFIIACAFILIGELNLIAPLI 601
            |.:..|..||::.|.:.:|::.|.:.:.|.|.|.|..||....||.::..||:|:|::|::||::
Mouse   322 SCMGGLYGAPRILQCIAQDKVIPALAFLANGKGPNKTPVAAICLTSLVTMAFVLVGQVNVLAPVV 386

  Fly   602 SNFFLAAYMLINFSTFHASLA-------------------------------------------- 622
            :..|:..|:::::|.|..|:|
Mouse   387 TINFMLTYIMVDYSYFALSMAHCGLAPSPEPVPRQGPDTLHCSEHLLQDRAPSYGSDVPARSLSE 451

  Fly   623 ---------------------------------------------------------KPVGW--- 627
                                                                     .|:.:
Mouse   452 GTLLEFTKDMDQFLQPIEELESRQLGSREGNNPKNQKRKGKKGAKQTLQDSFLLDPGSPLSFPTR 516

  Fly   628 ----------------------------------------------------------RPTFKY- 633
                                                                      ||:..|
Mouse   517 TSERLSVAFCGEQESYQKQQTSRSESHDHLVPDLRNQPRVNREDFFLKCRLQEQEIQRRPSVFYA 581

  Fly   634 --YNMWLSLLGAILCVAVMFLISWATALITFAAVLALYLIVAYRKPDVNWGSTTQ---AQTYKNA 693
              .|.|:|||||:..:.:||:|.|...|.:......:|..:....|.:..||.:.   .|..|:.
Mouse   582 CMCNPWVSLLGALASLLIMFVIQWLYTLASMGVAALVYFYIGQASPGLYLGSASNFSFFQWMKSF 646

  Fly   694 LM-SVQQLNNVEEHVKNYRPQILVLSGLPNTRPVLVDLA 731
            |: |.:.|.:.:|.:      ||..|      |..||:|
Mouse   647 LVPSCRSLRSAQEQI------ILAPS------PAKVDMA 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588
		2a30	155..1207	CDD:273347	177/689 (26%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	50/322 (16%)
		SLC12	724..1207	CDD:281515	4/8 (50%)
Slc12a8	NP_001357928.1	2a30	34..>420	CDD:273347	144/422 (34%)
Slc12a8	NP_001357928.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	472..512		1/39 (3%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810