Protein Alignment Ncc69 and SLC12A7

DIOPT Version :9

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: XP_011512243.2
• Gene: SLC12A7 / 10723
• HGNCID: 10915
• Length: 1111
• Species: Homo sapiens
• Alignment Length: 1361
• Identity: 345/1361 - (25%)
• Similarity: 531/1361 - (39%)
• Gaps: 425/1361 - (31%)

  Fly    19 RFQVNPVNGNSRKSQGADGPGSGSGAGAGAGAGAGE-DGPHEVYRRLTN------AEGELLEDDT 76
            ||.|.|..|                 |||.||..|: ..|....||..:      |..|..::|.
Human     4 RFVVTPAAG-----------------GAGPGAKEGDSQRPTPSPRRAPDPGLDPAAAPEPPDEDP 51

  Fly    77 FDATQMLNQRQPRQQRQSIKSSFRDKDKPSRFKDLQTTTRFQVDPQNEESDESNDSQEERELLDN 141
            ...  :|..|:                 |.|:.|        .:|: |.|...|:.:.|:|....
Human    52 LPI--LLYCRE-----------------PGRYGD--------GNPR-ENSPFLNNVEVEQESFFE 88

  Fly   142 EYDTKYGKSFRHFTREALPRLDNYRNMMSIQAAYRPTLDELHNATLVGKNTHSLTRNQDPESGIL 206
                  ||:...|..|    :|:...:.|:       |::|.|.|.:.:..  :...:|.||...
Human    89 ------GKNMALFEEE----MDSNPMVSSL-------LNKLANYTNLSQGV--VEHEEDEESRRR 134

  Fly   207 NG-VLKFGWIKGVLVRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAIST 270
            .. ..:.|...||.:.||.||.||:|||||:|:||.|||:|.|:::......|.:||:|||||:|
Human   135 EAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIAT 199

  Fly   271 NGVIKGGGTYYMISRSLGPEFGGSIGLIFSLANAVACAMYVVGFCESMLAMMTTFGWEIID---- 331
            |||:..||:||||||||||||||::||.|.|....|.|||::|..|..|..::. |..|..
Human   200 NGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISP-GAAIFQAEAA 263

  Fly   332 GG-----VQDVRIIGCITILLLLIIVVVGMEWEAKAQIGLL---IILLVAIGDFVIGSFIGP--- 385
            ||     :.::|:.|..|::|:.::|.||:::..|..:..|   ::.::||...||.|...|
Human   264 GGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKSAFDPPDI 328

  Fly   386 ----------------------------------------------------KSDAEMAKGFLGY 398
                                                                :::....:|..|.
Human   329 PVCLLGNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGSQPSAACDEYFIQNNVTEIQGIPGA 393

  Fly   399 NATLFKNNLFADYR-----PEKGG---------------------IQHDFFSVFAIFFPAATGIL 437
            .:.:|..||::.|.     .||.|                     |...|..:..|:||:.|||:
Human   394 ASGVFLENLWSTYAHAGAFVEKKGVPSVPVAEESRASALPYVLTDIAASFTLLVGIYFPSVTGIM 458

  Fly   438 AGANISGDLKDPQKSIPKGTILAIVITTGTYLIMVLQCGA----TVARDATGNLSDVVNGTFAFL 498
            ||:|.||||||.|||||.|||||||.|:..||..::..||    .|.||..|.
Human   459 AGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGE------------ 511

  Fly   499 DCQPGECNYGLQNSFQVIELVSAFGP-LIYAGCYAATLSSALASLVSAPKVFQALCKDELYPKIV 562
                     .||.:. ||.:::...| :|..|.:.:|..:.|.||..||::.||:.:|.:.|.:.
Human   512 ---------ALQGNL-VIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQ 566

  Fly   563 WFAKGYGK-NNEPVRGYVLTFIIACAFILIGELNLIAPLISNFFLAAYMLINFSTFHASLAKPVG 626
            .|  |:|| |.||....:||.:|....|||..|:.:||::|.|||..|:.:|.:....:|.:...
Human   567 VF--GHGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLRTPN 629

  Fly   627 WRPTFKYYNMWLSLLGAILCVAVMFLISWATALITFAAVLALYLIVAYRKPDVNWGSTTQAQTYK 691
            |||.||:|:..||.||..||:|:||:.||..||........:|..:.||..:..||...:..:..
Human   630 WRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLN 694

  Fly   692 NALMSVQQLNNVEEHVKNYRPQILVLSGLPNTR----PVLVDLAYMLTKNLSLLVCGHVLKGSSS 752
            .|..::.::.:...|.||:|||:||:..|...:    |.|:.....|.....|.:.|.||:|
Human   695 AARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEG--- 756

  Fly   753 QKYRTYL---------QERAGNWFRKHRVKGFYALVDGEDFESGTRALMQATGIGKLKPNIILMG 808
                |||         :|...:.....:.|||..||.......|...|:|:.|:|.||.|.:||.
Human   757 ----TYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMA 817

  Fly   809 YKTDWQTCDHKELDQYFNVMHKALDMYLSVAILRVPQGLDCSQVLGSQDGWKTVSDVPRTLQPNE 873
            :...|     |:.|..|:                                ||...|..|
Human   818 WPASW-----KQEDNPFS--------------------------------WKNFVDTVR------ 839

  Fly   874 SSGDLQAVDSSVRNGLSGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPGA 938
               |..|...::.  ::.::||..:|  ||                    ||
Human   840 ---DTTAAHQALL--VAKNVDSFPQN--QE--------------------RF------------- 864

  Fly   939 ASSTSDLSFIAGNQSKDVSGMPDPLDAKSANLVSNSLRKSKLKHDDPASLYKGPGGAELPKEVLA 1003
                                                                  ||..
Human   865 ------------------------------------------------------GGGH------- 868

  Fly  1004 DLTQFTRKRSHAVIDVWWLYDDGGLTLLLPYIISTRRTWQSCKLRVYALANKNSELEFEQRSMAS 1068
                         |||||:..|||:.:|||:::...:.|:.|::|::.:|..:......::.:..
Human   869 -------------IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQM 920

  Fly  1069 LLSKFRI------------DYS----DLTLIPD----------ITKKPQETSTQFFNE------- 1100
            .|...||            |.|    :.||:.:          ::|..||...|..::
Human   921 FLYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQMQLSKNEQEREAQLIHDRNTASHT 985

  Fly  1101 --LIKDFVVTEKDGENGTSSRATL------NEDDALITDDDLLAVQ------DKTN-----RYLR 1146
              ..:.......|....|.:|..|      :.|.:|....||.:::      |::|     ..::
Human   986 AAAARTQAPPTPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFSMKPEWGNLDQSNVRRMHTAVK 1050

  Fly  1147 LREYLREQSTKSDLVVMTLPMPRKNIVSAPLYMAWLESLSRDMPPFLFVRGNQTSVLTFYS 1207
            |...:..:|..:.||::.:|.|.||......||.:||.|:..:...|.|||....|:|.||
Human  1051 LNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS 1111

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588	7/38 (18%)
		2a30	155..1207	CDD:273347	312/1216 (26%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	58/159 (36%)
		SLC12	724..1207	CDD:281515	101/547 (18%)
SLC12A7	XP_011512243.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158229
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850