DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ncc69 and slc12a6

DIOPT Version :9

Sequence 1:	NP_001261758.1	Gene:	Ncc69 / 39410	FlyBaseID:	FBgn0036279	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	XP_009298223.2	Gene:	slc12a6 / 100330290	ZFINID:	ZDB-GENE-160113-148	Length:	226	Species:	Danio rerio

Alignment Length:	375	Identity:	62/375 - (16%)
Similarity:	109/375 - (29%)	Gaps:	174/375 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   704 EEHVKNYRPQILVLSGLPNTRPVLVDLAYMLTKNLSLLVCGHVLKGSSSQKYRTYL--QERAGNW 766
            :.|||:               |.|:..|..|.....|.:.|.|:.|:....|...|  ::...:.
Zfish     3 DAHVKS---------------PRLLTFASQLKAGKGLTIVGTVIPGNFLHTYGEALAAEQTLKHL 52

  Fly   767 FRKHRVKGFYALVDGEDFESGTRALMQATGIGKLKPNIILMGYKTDWQTCDHKELDQYFNVMHKA 831
            ..|.|||||...:..:....|...::|::|:|.:|.|.::||:...|:..:.
Zfish    53 MEKERVKGFVQCIVAQKPREGISHMIQSSGLGGMKHNTVVMGWPHAWRQSED------------- 104

  Fly   832 LDMYLSVAILRVPQGLDCSQVLGSQDGWKTVSDVPRTLQPNESSGDLQAVDSSVRNGLSGSIDSL 896
                        ||            .|||..:..|
Zfish   105 ------------PQ------------SWKTFINTVR----------------------------- 116

  Fly   897 SRNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGNQSKDVSGMPD 961
                                                      .::|:.|:.:.   .|::|..|
Zfish   117 ------------------------------------------VTTTAHLALLV---LKNISLFP- 135

  Fly   962 PLDAKSANLVSNSLRKSKLKHDDPASLYKGPGGAELPKEVLADLTQFTRKRSHAVIDVWWLYDDG 1026
                      |||                                   ...:...||:||:..||
Zfish   136 ----------SNS-----------------------------------EACTEGFIDIWWIVHDG 155

  Fly  1027 GLTLLLPYIISTRRTWQSCKLRVYALANKNSELEFEQRSMASLLSKFRID 1076
            |:.:|||:::...:.|:.|.||::.:|.........::.:|:.|...|||
Zfish   156 GMLMLLPFLLRQHKVWRKCALRIFTVAQMEDNSIQMKKDLATFLYHLRID 205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588
		2a30	155..1207	CDD:273347	62/375 (17%)
		ArsB_NhaD_permease	<524..>682	CDD:304373
		SLC12	724..1207	CDD:281515	59/355 (17%)
slc12a6	XP_009298223.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594106
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840