Protein Alignment Ncc69 and slc12a1

DIOPT Version :9

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: XP_021323409.1
• Gene: slc12a1 / 100329975
• ZFINID: ZDB-GENE-080130-3
• Length: 1037
• Species: Danio rerio
• Alignment Length: 1130
• Identity: 500/1130 - (44%)
• Similarity: 688/1130 - (60%)
• Gaps: 149/1130 - (13%)

  Fly   121 PQNEESD--ESNDSQEERELLDNEYDTKYGKSFRHFTREALPRLDNYRNMMSIQA--AYRPTLDE 181
            ||.||:.  .:.....||..:.:...:.:|    |.|.:.:|..|.|||..||..  |.||:|.|
Zfish    14 PQYEETSFCTNGFGNGERRAIRSSVVSAFG----HDTLDRVPNPDFYRNAASISGHRAVRPSLHE 74

  Fly   182 LH---------------------NATLVGKNTHSLTRNQDPESGILNGVLKFGWIKGVLVRCLLN 225
            ||                     :::.:| :..|:|..::.::|   ||:||||||||||||:||
Zfish    75 LHDVFQKNGGLNLPSPVEDSEGVDSSTLG-DVESVTPLEEKDTG---GVVKFGWIKGVLVRCMLN 135

  Fly   226 IWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMISRSLGPE 290
            |||||||:|||||.||||:..|.|::|.:..||::|.||||||.||||::|||.||:||||||||
Zfish   136 IWGVMLFIRLSWVFGQAGIGLGIVVVLLSMVVTSVTCLSMSAICTNGVVRGGGAYYLISRSLGPE 200

  Fly   291 FGGSIGLIFSLANAVACAMYVVGFCESMLAMMTTFGWEIIDGGVQDVRIIGCITILLLLIIVVVG 355
            |||||||||:.|||||.|||||||.|:::.::......|:| ...|:|||||||::||:.|.|.|
Zfish   201 FGGSIGLIFAFANAVAVAMYVVGFAETVVELLKDSNALIVD-PTNDIRIIGCITVVLLMGITVAG 264

  Fly   356 MEWEAKAQIGLLIILLVAIGDFVIGSFIGPKSDAEMAKGFLGYNATLFKNNLFADYRPEKGGIQH 420
            ||||||||:.||:||||||.:..:|:.| |.:..:.:|||..|:.::.|.|...|:|..:
Zfish   265 MEWEAKAQVALLVILLVAIANVFVGTVI-PSTQDKRSKGFFNYHESIAKENFIPDFRDGE----- 323

  Fly   421 DFFSVFAIFFPAATGILAGANISGDLKDPQKSIPKGTILAIVITTGTYLIMVLQCGATVARDATG 485
            .|||||||||||||||||||||||||:|||.::||||:|||.||..|||.:.|....||.|||||
Zfish   324 TFFSVFAIFFPAATGILAGANISGDLRDPQGALPKGTLLAIFITGVTYLGIALVVSVTVVRDATG 388

  Fly   486 NLSDVVNG------------TFAFLDCQPGECNYGLQNSFQVIELVSAFGPLIYAGCYAATLSSA 538
            |.:|.:..            .:.|..||..:|||||.|:|||:.|||.|||||.||.::||||||
Zfish   389 NRNDTIQAGASCNFSSACDFGYDFSICQTTKCNYGLMNNFQVMTLVSGFGPLITAGTFSATLSSA 453

  Fly   539 LASLVSAPKVFQALCKDELYPKIVWFAKGYGKNNEPVRGYVLTFIIACAFILIGELNLIAPLISN 603
            |||||||||||||||||.:|..:.:||||:||||||:||||||||||.|||||.:||.|||:|||
Zfish   454 LASLVSAPKVFQALCKDNIYKALKFFAKGHGKNNEPIRGYVLTFIIAVAFILIAQLNTIAPIISN 518

  Fly   604 FFLAAYMLINFSTFHASLAKPVGWRPTFKYYNMWLSLLGAILCVAVMFLISWATALITFAAVLAL 668
            ||||:|.|||:|.||||.||..||||.:|||||||||.||:||.||||:|:|..||:|:.....|
Zfish   519 FFLASYALINYSCFHASYAKSPGWRPAYKYYNMWLSLFGAVLCCAVMFVINWWAALLTYGIEFFL 583

  Fly   669 YLIVAYRKPDVNWGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQILVLSGLPNTRPVLVDLAYM 733
            |:.|..:||||||||:|||.|:.||:.:...|:.|::|:||:||:.|||:|.|.:||.|:||::.
Zfish   584 YIYVTVKKPDVNWGSSTQAVTFINAVNNALILSGVDDHIKNFRPKCLVLTGSPRSRPALLDLSHS 648

  Fly   734 LTKNLSLLVCGHVLKGSSSQKYRTYLQERAGN--WFRKHRVKGFYALVDGEDFESGTRALMQATG 796
            .|||..|.:...|..||..:..:..::....|  |..|.:.|.||..:..:....|.:|||||:|
Zfish   649 FTKNYGLCLTCEVFVGSRDKNLQDMIEGDVQNQLWLNKQKHKAFYTPIASDTLRDGAQALMQASG 713

  Fly   797 IGKLKPNIILMGYKTDWQTCDHKELDQYFNVMHKALDMYLSVAILRVPQGLDCSQVLGSQDGWKT 861
            :|::|||.:::|:|.||:|...:::..|..::|...|..|...|:||.||:|.|.:|
Zfish   714 LGRMKPNTVMLGFKRDWRTSKPQDVQNYVGILHDTFDFELGTVIMRVSQGMDISHIL-------- 770

  Fly   862 VSDVPRTLQPNESSGDLQAVDSSVRNGLSGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRFK 926
                                                  .::|:..|..|   ||.:|::.:..|:
Zfish   771 --------------------------------------KAEEEMERMIL---EQQALEMEENDFQ 794

  Fly   927 QGLR----RMRSWPGAASSTSDLSFIAGNQSKDVSGMPDPLDAKSANLVSNSLRKSKLKHDDPAS 987
            .|.|    |.:..| ....||.:|.          |:|...|.
Zfish   795 PGPRGFFNRAKKTP-KKEPTSKVSL----------GVPQASDL---------------------- 826

  Fly   988 LYKGPGGAELPKEVLADLTQFTRKRSHAVIDVWWLYDDGGLTLLLPYIISTRRTWQSCKLRVYAL 1052
                   |:|.:.::....||.:::....||||||:||||||||||:|::||:.|:.|:||:: :
Zfish   827 -------AKLNQRLVEASGQFKQQQGKGNIDVWWLFDDGGLTLLLPHILTTRKKWRECRLRIF-I 883

  Fly  1053 ANKNSELEFEQRSMASLLSKFRIDYSDLTLIPDITKKPQETSTQFFNELIKDFVVTEKDGENGTS 1117
            |.:...::.::..|..||.||||...|:.:|.|:..:|...:.:.|.::|:.|.:.| ..::.:.
Zfish   884 AGQPERIQQDKEEMQLLLKKFRIKCEDIKVISDLNIRPSAENWKLFEDMIEPFRLHE-GSKDSSQ 947

  Fly  1118 SRATLNEDDALITDDDLLAVQDKTNRYLRLREYLREQSTKSDLVVMTLPMPRKNIVSAPLYMAWL 1182
            :.|...|....|||.:|.|.:.||...:||.|.|:|.|..:.|:|::||:.||..||..||||||
Zfish   948 TEALRKEQPWKITDAELDAFEQKTMLQVRLNELLQESSRAAKLIVVSLPIARKGSVSDHLYMAWL 1012

  Fly  1183 ESLSRDMPPFLFVRGNQTSVLTFYS 1207
            |:|::::||.|.:|||..||||.||
Zfish  1013 EALTKNLPPTLLIRGNHKSVLTIYS 1037

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588	15/40 (38%)
		2a30	155..1207	CDD:273347	490/1092 (45%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	111/157 (71%)
		SLC12	724..1207	CDD:281515	147/488 (30%)
slc12a1	XP_021323409.1	2a30	45..1037	CDD:273347	490/1093 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	592	1.000	Domainoid score	I198
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D135130at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101360
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.930