Protein Alignment Ncc69 and slc12a2

DIOPT Version :9

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: XP_002931755.1
• Gene: slc12a2 / 100038244
• XenbaseID: XB-GENE-489652
• Length: 1161
• Species: Xenopus tropicalis
• Alignment Length: 1249
• Identity: 545/1249 - (43%)
• Similarity: 729/1249 - (58%)
• Gaps: 226/1249 - (18%)

  Fly    10 GSAADRPPNRFQVNPVN-----GNSRKSQGADGPGSGSGAGAG------AGAGAGEDGPHEVYRR 63
            ||.::....||:||.|:     |:|.::.|.||.|.|.....|      ....:|..|.|..|
 Frog    88 GSGSEEAKGRFRVNFVDPASPGGSSPENAGVDGGGGGVSFQNGDTVLSEGSLHSGGTGHHYHY-- 150

  Fly    64 LTNAEGELLEDDTFDATQMLNQRQPRQQRQSIKSSFRDKDKPSRFKDLQTTTRFQVDPQNEESDE 128
                                                                             
 Frog   151 ----------------------------------------------------------------- 150

  Fly   129 SNDSQEERELLDNEYDTKYGKSFRHFTREALPRLDNYRNMMSI--QAAYRPTLDELHNATLVGKN 191
                       |...:|.|.::|.|.|.:|:||:|:||:..:.  :...||:|.|||:..
 Frog   151 -----------DTHTNTYYLRTFGHNTIDAVPRIDHYRHTAADLGEKLLRPSLAELHDEL----- 199

  Fly   192 THSLTRNQDP-ESGILN------------------GVLKFGWIKGVLVRCLLNIWGVMLFLRLSW 237
                  :::| |.|..|                  ||:||||||||||||:|||||||||:||||
 Frog   200 ------DKEPFEDGFANGEEGTPTGDAATTVADSKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSW 258

  Fly   238 VVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMISRSLGPEFGGSIGLIFSLA 302
            :|||||:....|:|...|.|||||.||.|||:|||.::|||.||:|||||||||||:|||||:.|
 Frog   259 IVGQAGIGLTVVVISMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFA 323

  Fly   303 NAVACAMYVVGFCESMLAMMTTFGWEIIDGGVQDVRIIGCITILLLLIIVVVGMEWEAKAQIGLL 367
            ||||.|||||||.|:::.::...|..::| .:.|:||||.||::|||.|.|.||||||||||.||
 Frog   324 NAVAVAMYVVGFAETVVELLKENGALMVD-DINDIRIIGAITVVLLLGISVAGMEWEAKAQIVLL 387

  Fly   368 IILLVAIGDFVIGSFIGPKSDAEMAKGFLGYNATLFKNNLFADYRPEKGGIQHDFFSVFAIFFPA 432
            :|||:||.||.||:.| |..| :..|||.||.|.:|..|...|:|..:     .|||||||||||
 Frog   388 VILLLAIVDFFIGTVI-PSED-KKPKGFFGYKADIFSENFGPDFREGE-----TFFSVFAIFFPA 445

  Fly   433 ATGILAGANISGDLKDPQKSIPKGTILAIVITTGTYLIMVLQCGATVARDATGNLSDVV------ 491
            ||||||||||||||.|||.:||:||:|||:|||..|:.:.:..|:.|.|||:|:::..:
 Frog   446 ATGILAGANISGDLADPQHAIPRGTLLAILITTVVYMGVAVSVGSCVVRDASGDVNSTLSAAMTN 510

  Fly   492 ------NGTFAFLDCQPGECNYGLQNSFQVIELVSAFGPLIYAGCYAATLSSALASLVSAPKVFQ 550
                  |..:.|..| ..||.|||.|||||:.:||.|.|||.||.::||||||||||||||||||
 Frog   511 CTTAACNLNYDFSSC-GHECKYGLMNSFQVMSMVSGFAPLITAGIFSATLSSALASLVSAPKVFQ 574

  Fly   551 ALCKDELYPKIVWFAKGYGKNNEPVRGYVLTFIIACAFILIGELNLIAPLISNFFLAAYMLINFS 615
            |||||.:||.:..|||||||||||:|||:||||||..||||.|||||||:|||||||:|.|||||
 Frog   575 ALCKDNIYPGLQMFAKGYGKNNEPLRGYLLTFIIALGFILIAELNLIAPIISNFFLASYALINFS 639

  Fly   616 TFHASLAKPVGWRPTFKYYNMWLSLLGAILCVAVMFLISWATALITFAAVLALYLIVAYRKPDVN 680
            .|||||||..||||.|:|||||:||:||:||..|||:|:|..||:|:..|:.||:.|.|:|||||
 Frog   640 VFHASLAKSPGWRPAFRYYNMWVSLIGALLCCGVMFVINWWAALLTYVIVIGLYIYVTYKKPDVN 704

  Fly   681 WGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQILVLSGLPNTRPVLVDLAYMLTKNLSLLVCGH 745
            |||:|||.||.|||....:|..||:||||:|||.|||.|.||:||.|:.|.:..|||:.|::|||
 Frog   705 WGSSTQALTYLNALQHTIRLAGVEDHVKNFRPQCLVLIGAPNSRPALLHLVHAFTKNVGLMICGH 769

  Fly   746 VLKGSSSQKYRTYL--QERAGNWFRKHRVKGFYALVDGEDFESGTRALMQATGIGKLKPNIILMG 808
            |..|...|..:..|  |.|...|..|::.|.||:.|..||...|.:.||||.|:|:::||.:::|
 Frog   770 VHMGPRRQAMKELLTDQARYQRWLIKNKTKAFYSPVHAEDLRDGAQYLMQAAGLGRMRPNTLVVG 834

  Fly   809 YKTDWQTCDHKELDQYFNVMHKALDMYLSVAILRVPQGLDCSQVLGSQDGWKTVSDVPRTLQPNE 873
            :|.:|..||.:|::.|.|:.|.|.|....|.::|:.:|||.|.:.|.::          .|...|
 Frog   835 FKKNWSQCDMREVETYINLFHDAFDFQYGVVVIRLKEGLDISHLQGQEE----------LLSSQE 889

  Fly   874 SSGDLQAVDSSVRNGLSGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPGA 938
            .|...:.|                                      :|.:.:.:......|.|.|
 Frog   890 KSPGTKDV--------------------------------------VVNVDYSKKAEAESSRPFA 916

  Fly   939 ASSTSDLSFIAGNQSKDVSGMP-DPLDAKSANLVSNSLRKSKLKHDDPASLYKGPG-GAELPKEV 1001
                ||.|.:.....:|....| .||                ||.|.     ||.| ..:...:.
 Frog   917 ----SDSSPMMRKDEEDDGKTPTQPL----------------LKKDS-----KGQGISLDTADQR 956

  Fly  1002 LADLT-QFTRKRSHAVIDVWWLYDDGGLTLLLPYIISTRRTWQSCKLRVYALANKNSELEFEQRS 1065
            |.|.: ||.:|:..:.||||||:||||||||:||:|::::.|:.||:||: :..|.:.::.::|:
 Frog   957 LLDASLQFQKKQGKSTIDVWWLFDDGGLTLLIPYLITSKKKWRDCKIRVF-IGGKINRIDHDRRA 1020

  Fly  1066 MASLLSKFRIDYSDLTLIPDITKKPQETSTQFFNELIKDFVV--TEKDGENGTSSRATLNEDDAL 1128
            ||:||||||||:||:.::.||..||::.:...|.|:|:.|.:  .|||.|.....:   .|:...
 Frog  1021 MATLLSKFRIDFSDIMVLGDINTKPKKENVAAFEEMIEPFRLHEDEKDQEVAEKMK---EEEPWR 1082

  Fly  1129 ITDDDLLAVQDKTNRYLRLREYLREQSTKSDLVVMTLPMPRKNIVSAPLYMAWLESLSRDMPPFL 1193
            |||::|...:.||:|.:||.|.|:|.|:.::.:||:||:.||:.||:.|||||:|:||:|:||.|
 Frog  1083 ITDNELELYKTKTHRQIRLNELLKEHSSTANAIVMSLPVARKSAVSSALYMAWIEALSKDLPPIL 1147

  Fly  1194 FVRGNQTSVLTFYS 1207
            .||||..|||||||
 Frog  1148 LVRGNHQSVLTFYS 1161

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588	15/40 (38%)
		2a30	155..1207	CDD:273347	519/1091 (48%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	115/157 (73%)
		SLC12	724..1207	CDD:281515	169/489 (35%)
slc12a2	XP_002931755.1	2a30	165..1161	CDD:273347	519/1092 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	617	1.000	Domainoid score	I183
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20283
Inparanoid	1	1.050	975	1.000	Inparanoid score	I317
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D135130at33208
OrthoFinder	1	1.000	-	-		FOG0001536
OrthoInspector	1	1.000	-	-		mtm9379
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X709
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060