Protein Alignment Ncc69 and slc12a3l

DIOPT Version :9

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: XP_002934326.2
• Gene: slc12a3l / 100038063
• XenbaseID: XB-GENE-479312
• Length: 1115
• Species: Xenopus tropicalis
• Alignment Length: 1278
• Identity: 485/1278 - (37%)
• Similarity: 685/1278 - (53%)
• Gaps: 251/1278 - (19%)

  Fly    14 DRPPN------RFQVNPVNGNSRKSQGA----DGPGSGSG------AGAGAG-------AGAGED 55
            |.|.|      ||.|.  :.:|.:|...    ||....||      |.||..       ..:|.|
 Frog     2 DCPENPAFSIGRFTVQ--HADSFRSDKTPYRNDGDLEVSGDIEETLAKAGKSESMESLECSSGSD 64

  Fly    56 GPHEVYRRLTNAEG-ELLEDDTFDATQMLNQRQPRQQRQSIKS---------SFRDKDKPSRFKD 110
            .....|...|:.:. |:.|::..:|.|.||        |||::         ...|..||....|
 Frog    65 VASSGYTSTTDGQVLEIPEENVQEALQHLN--------QSIEAFSHGLHMFPCSTDNKKPEDCLD 121

  Fly   111 LQTTTRFQVDPQNEESDESNDSQ--------EERELLDNEYDTKYGKSFRHFTREALPRLDNYRN 167
                 :.:|:.........|.|.        .:|:|..|             |.:|.||.:.|.|
 Frog   122 -----KIEVESSLSSGIALNPSALPYCQNLITKRQLAYN-------------TLDATPRHEFYIN 168

  Fly   168 MMS---IQAAYRPTLDELHNATLVGKNTHSLTRNQDPESGILN--------------------GV 209
            .::   ::.: ||:||.|.||.|....|..::.:||.|:|..|                    |.
 Frog   169 SVAPGRLKRS-RPSLDILRNAILDENETVPVSLDQDLETGNKNEPENPEMVNTKNNKKKKKESGP 232

  Fly   210 LKFGWIKGVLVRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVI 274
            ::|||:|||::||:||||||:|:|||.|:..|||:...:|:||.:..||:||.||:|||||||.:
 Frog   233 VRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIGLTWVIILMSVLVTSITGLSISAISTNGKV 297

  Fly   275 KGGGTYYMISRSLGPEFGGSIGLIFSLANAVACAMYVVGFCESMLAMMTTFGWEIIDGGVQDVRI 339
            |.||||::||||||||.||||||||:.|||||.||:.|||.|::..::..:. .:|...|.|:||
 Frog   298 KSGGTYFLISRSLGPELGGSIGLIFAFANAVAVAMHTVGFAETVRDLLIEYN-AVISDPVNDIRI 361

  Fly   340 IGCITILLLLIIVVVGMEWEAKAQIGLLIILLVAIGDFVIGSFIGPKSDAEMAKGFLGYNATLFK 404
            ||.||:.:||.:.:.||||||||||....:::|:...:.:|:.: |.|:.:.||||..|..::|.
 Frog   362 IGVITVTVLLGVSLAGMEWEAKAQIVFFFVIMVSFASYFVGTLM-PPSEEKQAKGFFSYQGSIFA 425

  Fly   405 NNLFADYRPEKGGIQHDFFSVFAIFFPAATGILAGANISGDLKDPQKSIPKGTILAIVITTGTYL 469
            .|:..|:|.|..    .||::|:||||:|||||||||||||||||..:|||||:|:|..||.:||
 Frog   426 ENIVPDWRGETS----SFFAMFSIFFPSATGILAGANISGDLKDPAVAIPKGTLLSIFWTTISYL 486

  Fly   470 IMVLQCGATVARDATGNLSDV--VNGT-----------FAFLDCQPGE-CNYGLQNSFQVIELVS 520
            .:....|:.|.|||:|.|:|.  :|.|           :.|..|:..| |.|||.|.:|.:.:||
 Frog   487 AISATIGSCVLRDASGILNDTIPINETTDCEGLSCQFGWNFTSCRETESCYYGLANHYQAMSMVS 551

  Fly   521 AFGPLIYAGCYAATLSSALASLVSAPKVFQALCKDELYPKIVWFAKGYGKNNEPVRGYVLTFIIA 585
            ||.|||.||.:|||||||||.|||||||||.||||:|||.|.:|.|||||||||:|||:|:|.||
 Frog   552 AFSPLITAGIFAATLSSALACLVSAPKVFQCLCKDKLYPFIGFFGKGYGKNNEPIRGYILSFAIA 616

  Fly   586 CAFILIGELNLIAPLISNFFLAAYMLINFSTFHASLAKPVGWRPTFKYYNMWLSLLGAILCVAVM 650
            .|||||.|||.|||:||||||.:|.|||||.||||:....||||:|:||:.|.||.||::.|.:|
 Frog   617 IAFILIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFRYYSKWTSLFGAVVSVVIM 681

  Fly   651 FLISWATALITFAAVLALYLIVAYRKPDVNWGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQIL 715
            ||::|..|:|..|.::.|...|.|:||:|||||:.||..|..||.....|:.|:|||||||||.|
 Frog   682 FLLTWWAAIIAVAIIIILLGYVTYKKPEVNWGSSVQAGAYNMALTYSVNLSGVQEHVKNYRPQCL 746

  Fly   716 VLSGLPNTRPVLVDLAYMLTKNLSLLVCGHVLKGSSSQKYRTYLQERAG--NWFRKHRVKGFYAL 778
            ||:|.||.||.|||....:|||.||::||:|...|..      :.:..|  .|....:|..||::
 Frog   747 VLTGPPNFRPALVDFVSSVTKNTSLMICGNVAIDSDK------ITDSEGQLRWLNTRKVISFYSM 805

  Fly   779 VDGEDFESGTRALMQATGIGKLKPNIILMGYKTDWQTCDHKELDQYFNVMHKALDMYLSVAILRV 843
            :..:...:|.:.|||.:|:|:||||.:::|||::||:...:.|::|..::|.|.|...:|.|||:
 Frog   806 IYEKTLRAGAKNLMQVSGLGRLKPNTLVLGYKSNWQSDSVQNLEEYVGIIHDAFDCQFAVCILRI 870

  Fly   844 PQGLDCSQVLGSQDGWKTVSDVPRTLQPNESSGDLQAVDSSVRNGLSGSIDSLSRNVSQEDRNRN 908
            ..|||.||.:..|
 Frog   871 NDGLDVSQKVQGQ---------------------------------------------------- 883

  Fly   909 QLVHSEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGNQSKDVSGMPDPLDAKSANLVSN 973
                        |.|.|                          |..|.....|..|.|
 Frog   884 ------------VNLAF--------------------------QDSDNEAFSDKEDEK------- 903

  Fly   974 SLRKSKLKHDDPASLYKGPGGAELPKEVLADLTQFTRKRSHAVIDVWWLYDDGGLTLLLPYIIST 1038
                      :|.|        .:|:.:....|:|..::....|.|:||.||||||||:||::..
 Frog   904 ----------EPHS--------PVPEILSQTNTEFQGRQGKKSIHVYWLSDDGGLTLLIPYLLKR 950

  Fly  1039 RRTWQSCKLRVYALANKNSELEFEQRSMASLLSKFRIDYSDLTLIPDITKKPQETSTQFFNELIK 1103
            ||.|..||::|: :..:..:.|.|::.|.|||.|||:.:.::.::.:..:||...:.:.|.:||.
 Frog   951 RRRWSQCKVKVF-IRCRTEKAEEEKKEMQSLLEKFRLGFQEVVVLTNADQKPHCRNMKVFEDLIA 1014

  Fly  1104 DFVVTEKDGENGTSSRATLNEDDAL----ITDDDLLAVQDKTNRYLRLREYLREQSTKSDLVVMT 1164
            .:.|         |:|...:|:..:    ||:.||:....|:.||:|:.|.|:|.|..:.|:.::
 Frog  1015 PYNV---------STRQRTSEEAEIPSCGITEKDLVHYMAKSERYVRMNEILKENSQDAALIAIS 1070

  Fly  1165 LPMPRKNIVSAPLYMAWLESLSRDM-PPFLFVRGNQTSVLTFY 1206
            ||:..::...:.||||||.|||||: ||.:|:||||...||.|
 Frog  1071 LPIVSRDTCPSSLYMAWLASLSRDLNPPIVFIRGNQQDALTVY 1113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588	10/41 (24%)
		2a30	155..1207	CDD:273347	447/1096 (41%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	102/157 (65%)
		SLC12	724..1207	CDD:281515	136/490 (28%)
slc12a3l	XP_002934326.2	2a30	155..1114	CDD:273347	448/1110 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	617	1.000	Domainoid score	I183
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D135130at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X709
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.030