DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CrzR and Ltb4r2

DIOPT Version :9

Sequence 1:	NP_001261755.1	Gene:	CrzR / 39409	FlyBaseID:	FBgn0036278	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_006519386.1	Gene:	Ltb4r2 / 57260	MGIID:	1888501	Length:	372	Species:	Mus musculus

Alignment Length:	412	Identity:	92/412 - (22%)
Similarity:	155/412 - (37%)	Gaps:	120/412 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 LAVMALFSLLGNLLTIWNI--YKTRISRRNSRHTWSAIYSLMFHLSIAD---VLVT--WFCIIGE 182
            |.:.||..|.||...:|::  ::....|       ....:|:.||::||   :|:|  :...:.:
Mouse    39 LLLAALLGLPGNGFVVWSLAGWRPTAGR-------PLAATLVLHLALADGAVLLLTPLFVAFLSQ 96

  Fly   183 AAWCYTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYP-----MKSLNMAKRCHR 242
            .|      |...::.||.|......|:|.|..:..|:.:.|.:||..|     ::|..:|:   |
Mouse    97 EA------WPLGQVGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALAR---R 152

  Fly   243 LLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQCVTHGFYTADWQEQMYATFTLVFTFLLPLCIL 307
            ||.|.::.:|||::|.....|:..|...:..:....|.        ..:.:...:..|:||...:
Mouse   153 LLLGVWLAALVLAVPAAVYRHLWGGRVCQLCHPSPVHA--------AAHLSLETLTAFVLPFGTV 209

  Fly   308 FGTYMSTFRTISSSEKMFQGSKLANYSTAKLPTQTNRQRLIHKAKMKSLRISVVIIIAFLICWTP 372
            .|.|..|...:..          |.:.:.:..|:..             |:...|::||.:.|.|
Mouse   210 LGCYGVTLARLRG----------ARWGSGRQGTRVG-------------RLVSAIVLAFGLLWAP 251

  Fly   373 YYVMMIMFMFL------NPDKRLGDDLQ------DAIFFFGMSNSLVNPLIY--GAFHLCPGKGG 423
            |:.:.::....      .|..|||...|      .|:.||   :|.|||::|  .|..|.|..|
Mouse   252 YHAVNLLQAVAALAPPEGPLARLGGAGQAARAGTTALAFF---SSSVNPVLYVFTAGDLLPRAG- 312

  Fly   424 KSSGGGGNNNAYSLNRGDSQRTPSMLTAVTQVDGTG---GSSRQMRAFRQQSYYRSSSNGTAGPG 485
                                  |..||.:  .:|:|   |.||             |..||....
Mouse   313 ----------------------PRFLTRL--FEGSGEARGGSR-------------SREGTMELR 340

  Fly   486 AAPFKEQVGLLHVGPGNGTPGG 507
            ..|   ::.::..|.|||.|||
Mouse   341 TTP---KLKVMGQGRGNGDPGG 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrzR	NP_001261755.1	7tm_4	127..>260	CDD:304433	37/144 (26%)
CrzR	NP_001261755.1	7tm_1	135..412	CDD:278431	64/300 (21%)
Ltb4r2	XP_006519386.1	7tm_GPCRs	33..312	CDD:421689	72/322 (22%)
		TM helix 1	34..60	CDD:410628	7/20 (35%)
		TM helix 2	69..94	CDD:410628	7/24 (29%)
		TM helix 3	106..136	CDD:410628	9/29 (31%)
		TM helix 4	148..168	CDD:410628	8/22 (36%)
		TM helix 5	190..215	CDD:410628	5/32 (16%)
		TM helix 6	229..259	CDD:410628	8/42 (19%)
		TM helix 7	279..304	CDD:410628	9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24230
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100