DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CrzR and LTB4R2

DIOPT Version :9

Sequence 1:	NP_001261755.1	Gene:	CrzR / 39409	FlyBaseID:	FBgn0036278	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001158164.1	Gene:	LTB4R2 / 56413	HGNCID:	19260	Length:	358	Species:	Homo sapiens

Alignment Length:	410	Identity:	92/410 - (22%)
Similarity:	157/410 - (38%)	Gaps:	112/410 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 LAVMALFSLLGNLLTIWNIYKTRISRRNSRHTWSAIYSLMFHLSIAD---VLVTWFCIIGEAAWC 186
            |.:.||..|.||...:|::...|.:|..     ....:|:.||::||   :|:|...:    |:.
Human    27 LLLAALLGLPGNGFVVWSLAGWRPARGR-----PLAATLVLHLALADGAVLLLTPLFV----AFL 82

  Fly   187 YTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYP-----MKSLNMAKRCHRLLGG 246
            ....|...:..||.|......|:|.|..:..|:.:.|.:||..|     ::|..:|:   |||..
Human    83 TRQAWPLGQAGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALAR---RLLLA 144

  Fly   247 TYILSLVLSLPQFFIFHVARGPFVEEFYQCVTHGFYTADWQEQMYATFTLVFTFLLPLCILFGTY 311
            .::.:|:|::|.....|:.|....:..:....|.        ..:.:...:..|:||..::.|.|
Human   145 VWLAALLLAVPAAVYRHLWRDRVCQLCHPSPVHA--------AAHLSLETLTAFVLPFGLMLGCY 201

  Fly   312 MSTFRTISSSEKMFQGSKLANYSTAKLPTQTNRQRLIHKAKMKSLRISVVIIIAFLICWTPYYVM 376
            ..|...:..          |.:.:.:           |.|::.  |:...|::||.:.|.||:.:
Human   202 SVTLARLRG----------ARWGSGR-----------HGARVG--RLVSAIVLAFGLLWAPYHAV 243

  Fly   377 MIM--FMFLNPDK----RLGDDLQ------DAIFFFGMSNSLVNPLIY--GAFHLCPGKGGKSSG 427
            .::  ...|.|.:    :||...|      .|:.||   :|.|||::|  .|..|.|..|
Human   244 NLLQAVAALAPPEGALAKLGGAGQAARAGTTALAFF---SSSVNPVLYVFTAGDLLPRAG----- 300

  Fly   428 GGGNNNAYSLNRGDSQRTPSMLTAVTQVDGT---GGSSRQMRAFRQQSYYRSSSNGTAGPGAAPF 489
                              |..||.:.:..|.   ||.||:               ||......|
Human   301 ------------------PRFLTRLFEGSGEARGGGRSRE---------------GTMELRTTP- 331

  Fly   490 KEQVGLLHVGPGNGTPGGSV 509
              |:.::..|.|||.|||.:
Human   332 --QLKVVGQGRGNGDPGGGM 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrzR	NP_001261755.1	7tm_4	127..>260	CDD:304433	36/140 (26%)
CrzR	NP_001261755.1	7tm_1	135..412	CDD:278431	64/296 (22%)
LTB4R2	NP_001158164.1	7tm_GPCRs	21..300	CDD:355774	72/318 (23%)
		TM helix 1	23..47	CDD:341315	7/19 (37%)
		TM helix 2	58..79	CDD:341315	7/20 (35%)
		TM helix 3	95..117	CDD:341315	6/21 (29%)
		TM helix 4	140..156	CDD:341315	5/15 (33%)
		TM helix 5	179..202	CDD:341315	4/22 (18%)
		TM helix 6	220..245	CDD:341315	8/26 (31%)
		TM helix 7	267..292	CDD:341315	9/27 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..358		16/57 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24230
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100