Protein Alignment CrzR and Qrfprl

DIOPT Version :10

• Sequence 1: NP_001261755.1
• Gene: CrzR / 39409
• FlyBaseID: FBgn0036278
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001102709.1
• Gene: Qrfprl / 500157
• RGDID: 1560028
• Length: 415
• Species: Rattus norvegicus
• Alignment Length: 328
• Identity: 80/328 - (24%)
• Similarity: 145/328 - (44%)
• Gaps: 60/328 - (18%)

  Fly   112 PQLSRSGLLKVYVLAVMALF--SLLGNLLTIWNIYKTRISRRNSRHTWSAIYSLMFHLSIADVLV 174
            |||.....|.: :||.:.:|  :|.||.|.::.:.:::..|     |.:.|:  :..|:::|:|:
  Rat    37 PQLPARARLAL-LLAGLLIFALALFGNALVVYVVTRSKAMR-----TVTNIF--ICSLALSDLLI 93

  Fly   175 TWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYP--MKSLNMA 237
            .:|||........:..||.....||:|...|..::......:..|.|:|...:.:|  ||.....
  Rat    94 VFFCIPVTMLQNVSDTWLGGAFICKMVPFVQCTAVVTEILTMTCIAVERHQGLVHPFKMKQQYTN 158

  Fly   238 KRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQCVTHGFYTADW----QEQMYATFTLVF 298
            :|...:||..:::::::..|   ::||.|.....:|.....|.....:|    .:::|.||.||.
  Rat   159 QRAFTMLGVVWLVAIIIGSP---MWHVQRLEIKYDFLYEKEHICCLEEWSSPVHQKIYTTFILVT 220

  Fly   299 TFLLPLCILFGTY---------------MSTFRTISSSEKMFQGSKLANYSTAKLPTQTNRQRLI 348
            .|||||.:|...|               .|..|||...| ||:                     |
  Rat   221 LFLLPLLLLSVLYGKIGYELWIKKRVGDGSVLRTIHGKE-MFK---------------------I 263

  Fly   349 HKAKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIF----FFGMSNSLVNP 409
            .:.|.:::.:.|.:::.|.:||.|::|:.:|..:.|.:|...:.....||    ..|..||:.||
  Rat   264 ARKKKRAVIMMVTVVVLFAVCWAPFHVVHMMIEYSNFEKEYDEVTIKMIFAIVQIIGFFNSICNP 328

  Fly   410 LIY 412
            ::|
  Rat   329 IVY 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CrzR	NP_001261755.1	7tmA_GnRHR_invertebrate	119..419	CDD:320506	77/321 (24%)
		TM helix 1	120..146	CDD:320506	8/27 (30%)
		TM helix 2	160..187	CDD:320506	7/26 (27%)
		TM helix 3	198..228	CDD:320506	7/29 (24%)
		TM helix 4	239..260	CDD:320506	4/20 (20%)
		TM helix 5	288..317	CDD:320506	13/43 (30%)
		TM helix 6	350..380	CDD:320506	7/29 (24%)
		TM helix 7	391..416	CDD:320506	8/26 (31%)
Qrfprl	NP_001102709.1	7tmA_QRFPR	60..342	CDD:320333	72/304 (24%)
		TM helix 2	79..105	CDD:320333	7/27 (26%)
		TM helix 3	117..147	CDD:320333	7/29 (24%)
		TM helix 4	160..181	CDD:320333	4/23 (17%)
		TM helix 5	210..235	CDD:320333	12/24 (50%)
		TM helix 6	265..295	CDD:320333	7/29 (24%)
		TM helix 7	310..335	CDD:320333	8/22 (36%)