DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CrzR and AkhR

DIOPT Version :9

Sequence 1:	NP_001261755.1	Gene:	CrzR / 39409	FlyBaseID:	FBgn0036278	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_995639.1	Gene:	AkhR / 33942	FlyBaseID:	FBgn0025595	Length:	455	Species:	Drosophila melanogaster

Alignment Length:	473	Identity:	135/473 - (28%)
Similarity:	229/473 - (48%)	Gaps:	79/473 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 ISNSSSLAHTNSR-HEAPPMAEQVPEHVMDHAPQLSRSGLLKVYVLAVMALFSLLGNLLTIWNIY 144
            :||.|::..||.. |....|       |.:...:||      :.|.:::.:.|.:||...::.:.
  Fly    13 LSNWSNVNDTNGTIHLTKDM-------VFNDGHRLS------ITVYSILFVISTIGNSTVLYLLT 64

  Fly   145 KTRISRRNSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSL 209
            |.|: |...|     |..::.||:|||::||...:..|..|.:|||||:.:|.|:|:..|::|.|
  Fly    65 KRRL-RGPLR-----IDIMLMHLAIADLMVTLLLMPMEIVWAWTVQWLSTDLMCRLMSFFRVFGL 123

  Fly   210 YLSTYVLVLIGVDRWIAVKYPMK-SLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEF 273
            |||:||:|.|.:||:.|:..|:| |.|   |...:|...::.|:|.|:||.|:||:...|.|..:
  Fly   124 YLSSYVMVCISLDRYFAILKPLKRSYN---RGRIMLACAWLGSVVCSIPQAFLFHLEEHPAVTGY 185

  Fly   274 YQCVTHGFYTADWQEQMYATFTLVFTFLLPLCILF-----GTYMSTFRTISSSEKMFQGSKLANY 333
            :|||....:.:|:.|::|...::...:..|| |:|     ..|:..:|   .|:::.:......:
  Fly   186 FQCVIFNSFRSDFDEKLYQAASMCSMYAFPL-IMFIYCYGAIYLEIYR---KSQRVLKDVIAERF 246

  Fly   334 STAKLPTQTNRQRLIHKAKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDK----RLGDDLQ 394
                   :.:...::.:||.::|::::.|:|.|:|||||||.:.:.:..   ||    ::...|:
  Fly   247 -------RRSNDDVLSRAKKRTLKMTITIVIVFIICWTPYYTISMWYWL---DKHSAGKINPLLR 301

  Fly   395 DAIFFFGMSNSLVNPLIYGAFHLCPGKGGKSSGGGGNNNAYSLNRGDSQRTPSMLTAVTQVDGTG 459
            .|:|.|..:||.:|||:||.:::        .|...|||            ||:....|.:....
  Fly   302 KALFIFASTNSCMNPLVYGLYNI--------RGRMNNNN------------PSVNNRHTSLSNRL 346

  Fly   460 GSSRQMRAFRQQSYYRSSSNGTAGPGAAPFKEQVGLLHVGPGNGTPGGSVSSGA------TPQLI 518
            .||.|:  .::|....|..||.....||.......|.:|....||..|:.|:.|      ||.|.
  Fly   347 DSSNQL--MQKQLTNNSLLNGRGQVMAAAVSATTKLANVVSLKGTANGNGSAAAAGTVPITPPLT 409

  Fly   519 RKGSALL----ARQPSCL 532
            ...:.|.    |...|||
  Fly   410 VTIAPLATDDEANDDSCL 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrzR	NP_001261755.1	7tm_4	127..>260	CDD:304433	49/133 (37%)
CrzR	NP_001261755.1	7tm_1	135..412	CDD:278431	90/286 (31%)
AkhR	NP_995639.1	7tm_1	55..319	CDD:278431	90/286 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458953
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5517
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D31364at7147
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X690
	5	4.800