Protein Alignment CrzR and Gpr22

DIOPT Version :10

• Sequence 1: NP_001261755.1
• Gene: CrzR / 39409
• FlyBaseID: FBgn0036278
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001100192.1
• Gene: Gpr22 / 298944
• RGDID: 1310848
• Length: 469
• Species: Rattus norvegicus
• Alignment Length: 364
• Identity: 82/364 - (22%)
• Similarity: 134/364 - (36%)
• Gaps: 102/364 - (28%)

  Fly   113 QLSRSGLLKVYV-------LAVMALFSLLGNLL-TIWNIYKTRISRRNSRHTWSAIYSLMFHLSI 169
            |:|.:|.|.:.:       |.|:.|:.:..||: ::.||                   :..:|.:
  Rat    78 QVSLTGFLMLEIVLGLGSNLTVLVLYCMKSNLISSVSNI-------------------ITMNLHV 123

  Fly   170 ADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQ----MFSLYLSTYVLVLIGVDRW-IAVKY 229
            .||::...||    .....:..|:.|....|:..|.    .|:...:...:..|.:||: |:||.
  Rat   124 LDVIICVGCI----PLTIVILLLSLERNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKP 184

  Fly   230 PMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVE-EFYQ-------------CV-TH 279
            ..:.|.|. |...|:...:|.|       ||.|.:   ||:| .|:.             || |.
  Rat   185 ANRILTMG-RAVMLMTSIWIFS-------FFSFLI---PFIEVNFFSLQSGNAWENKTLLCVSTS 238

  Fly   280 GFYTADWQEQMY------------ATFTLVFTF---LLPLCILFGTYMST--------FRTIS-- 319
            .:||   :..||            ....::.|:   |..|.|..||..||        .:|||
  Rat   239 EYYT---ELGMYYHLLVQIPIFFFTVIVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLT 300

  Fly   320 --SSEKMFQGSKLANY---------STAKLPTQTNRQRLIHKAKMKSLRISVVIIIAFLICWTPY 373
              .:..|.|.|...|.         ....|.....|.|...:.:.:..::|::||..||:||||.
  Rat   301 THETTDMSQSSGGRNVVFGVRTSVSVIIALRRAVKRHRERRERQKRVFKMSLLIISTFLLCWTPI 365

  Fly   374 YVMMIMFMFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIY 412
            .|:....:.|.|...| ..|:..........::.:||:|
  Rat   366 SVLNTTILCLGPSDLL-VKLRLCFLVMAYGTTIFHPLLY 403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CrzR	NP_001261755.1	7tmA_GnRHR_invertebrate	119..419	CDD:320506	79/358 (22%)
		TM helix 1	120..146	CDD:320506	8/33 (24%)
		TM helix 2	160..187	CDD:320506	5/26 (19%)
		TM helix 3	198..228	CDD:320506	7/34 (21%)
		TM helix 4	239..260	CDD:320506	4/20 (20%)
		TM helix 5	288..317	CDD:320506	10/51 (20%)
		TM helix 6	350..380	CDD:320506	10/29 (34%)
		TM helix 7	391..416	CDD:320506	4/22 (18%)
Gpr22	NP_001100192.1	7tm_classA_rhodopsin-like	81..406	CDD:410626	80/361 (22%)
		TM helix 1	81..106	CDD:410626	5/24 (21%)
		TM helix 2	114..140	CDD:410626	7/48 (15%)
		TM helix 3	152..182	CDD:410626	6/29 (21%)
		TM helix 4	193..212	CDD:410626	7/28 (25%)
		TM helix 5	245..270	CDD:410626	3/24 (13%)
		TM helix 6	342..371	CDD:410626	10/28 (36%)
		TM helix 7	382..406	CDD:410626	4/22 (18%)