DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CrzR and GNRHR

DIOPT Version :9

Sequence 1:	NP_001261755.1	Gene:	CrzR / 39409	FlyBaseID:	FBgn0036278	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_000397.1	Gene:	GNRHR / 2798	HGNCID:	4421	Length:	328	Species:	Homo sapiens

Alignment Length:	343	Identity:	100/343 - (29%)
Similarity:	177/343 - (51%)	Gaps:	21/343 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 ISNSSSLAHTNSRHEAPPMAEQVPEHVMDHAPQLSRSGLLKVYVLAVMALFSLLGNLLTIWNIYK 145
            ::||:| ...|..| ...:...:| .:..:.|.|:.||.::|.|...:.|.|...|...:..:.|
Human     1 MANSAS-PEQNQNH-CSAINNSIP-LMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQK 62

  Fly   146 TRISRRNSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSLY 210
            ....:...:.. |.:..|:.||::|::|.|...:..:..|..||||.|.||.||::...::||:|
Human    63 WTQKKEKGKKL-SRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMY 126

  Fly   211 LSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIF---HVA-RGPFVE 271
            ...:::|:|.:||.:|:..|:...:.:|....::|..:|||.|.:.||.:||   |:| .....:
Human   127 APAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTK 191

  Fly   272 EFYQCVTHGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKLANYSTA 336
            .|.|||||..::..|.:..|..||....|::||.|:.         |.:::.:|..:::.:....
Human   192 VFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIML---------ICNAKIIFTLTRVLHQDPH 247

  Fly   337 KLPTQTNRQRLIHKAKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPD--KRLGDDLQDAIFF 399
            :|....::.. |.:|::|:|:::|....:|.:|||||||:.|.:.| :|:  .||.|.:....|.
Human   248 ELQLNQSKNN-IPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWF-DPEMLNRLSDPVNHFFFL 310

  Fly   400 FGMSNSLVNPLIYGAFHL 417
            |...|...:|||||.|.|
Human   311 FAFLNPCFDPLIYGYFSL 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrzR	NP_001261755.1	7tm_4	127..>260	CDD:304433	38/132 (29%)
CrzR	NP_001261755.1	7tm_1	135..412	CDD:278431	81/282 (29%)
GNRHR	NP_000397.1	7tm_GPCRs	36..328	CDD:333717	89/303 (29%)
		TM helix 1	38..67	CDD:320095	6/28 (21%)
		TM helix 2	77..100	CDD:320095	6/22 (27%)
		TM helix 3	115..137	CDD:320095	6/21 (29%)
		TM helix 4	158..174	CDD:320095	5/15 (33%)
		TM helix 5	209..232	CDD:320095	8/31 (26%)
		TM helix 6	263..288	CDD:320095	11/24 (46%)
		TM helix 7	302..327	CDD:320095	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5517
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368588at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X690
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.830