DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CrzR and gnrr-3

DIOPT Version :9

Sequence 1:	NP_001261755.1	Gene:	CrzR / 39409	FlyBaseID:	FBgn0036278	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_509685.2	Gene:	gnrr-3 / 191147	WormBaseID:	WBGene00013871	Length:	395	Species:	Caenorhabditis elegans

Alignment Length:	468	Identity:	96/468 - (20%)
Similarity:	171/468 - (36%)	Gaps:	137/468 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 VMDHAPQLSRSGLLKV-YVLAVMALFSLLGNLLTIWNIYKTRISRRNSRH--TWSAIYSLMFHLS 168
            ||.|    |.|.:::: |.||    |.::|..:.|:...||   .||.|.  ..|.:..|...|.
Worm    10 VMMH----STSEVIEMFYQLA----FFIIGTPINIFAFVKT---SRNVREGGVESRLVKLSRQLL 63

  Fly   169 IADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKS 233
            ||.::|.:...|..:.|.|.:.|...::.|::.........:|.:.::..|.:|....:..|:.|
Worm    64 IAHIMVLFMYGIWRSYWIYNIVWTQGDIMCRVFSFLCALPFHLWSNMVAAIAIDMLCCITSPLSS 128

  Fly   234 LNM-AKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFV---EEFYQCVTHGFYTADWQEQMYATF 294
            ... |.|.:.|:...:..::|.:.|    ..:.||...   |:.|||...   |..:.:.:...|
Worm   129 YRTGANRVNWLITLAWGFAVVCASP----MSILRGTIQINDEDMYQCYPR---TDVFNDDVLIAF 186

  Fly   295 TL---VFTFLLPLCILFGTYMS---TFRTISSSEKMFQGSKLANYSTAKLPTQTNRQRLIHKAKM 353
            .|   :.:|.:||.|:...|::   :.|...:..::.|....:...|             :..|.
Worm   187 NLFHVITSFYIPLLIVIICYLAIGVSIRKQMAERRLLQDGGQSGQKT-------------NNTKA 238

  Fly   354 KSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDLQDAIFFFG------MSNSLVNPLIY 412
            :.||.||.||..||..|.||.|:.::.:..     :.::.|:.:....      ::::.:||.:|
Worm   239 RFLRASVAIICTFLFTWLPYQVLALLRIVC-----VSENCQEIVSKLNWLQAIIIASTCINPFLY 298

  Fly   413 GAFHLCPGKGGKSSGGGGNNNAYSLNRGDSQRTPSMLTAVTQVDGTGGSSRQMRAFRQQSYYRSS 477
             .|...|                                                 ::.|||.|:
Worm   299 -RFGTEP-------------------------------------------------KRNSYYCST 313

  Fly   478 SNGTAGPGAAPFKEQVGLLHVGPGNGTPGGSVSSGATPQLI----------------------RK 520
            .: |||      ||:|||......:|.|.   .||..||.|                      |:
Worm   314 MD-TAG------KEEVGLSADRRRSGKPR---PSGLLPQQIAHTENKTPPKCRLEVHAPRFENRR 368

  Fly   521 GSALLARQPSCLR 533
            .|.:.::.|..:|
Worm   369 ASQIDSKTPKVMR 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrzR	NP_001261755.1	7tm_4	127..>260	CDD:304433	29/135 (21%)
CrzR	NP_001261755.1	7tm_1	135..412	CDD:278431	61/294 (21%)
gnrr-3	NP_509685.2	7tm_classA_rhodopsin-like	62..298	CDD:381740	52/260 (20%)
		TM helix 3	94..116	CDD:381740	2/21 (10%)
		TM helix 4	138..154	CDD:381740	3/19 (16%)
		TM helix 5	184..207	CDD:381740	6/22 (27%)
		TM helix 6	238..263	CDD:381740	12/24 (50%)
		TM helix 7	276..298	CDD:381740	2/21 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24230
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.970