Protein Alignment CrzR and gnrr-5

DIOPT Version :10

• Sequence 1: NP_001261755.1
• Gene: CrzR / 39409
• FlyBaseID: FBgn0036278
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_504228.2
• Gene: gnrr-5 / 186759
• WormBaseID: WBGene00019224
• Length: 423
• Species: Caenorhabditis elegans
• Alignment Length: 421
• Identity: 105/421 - (24%)
• Similarity: 173/421 - (41%)
• Gaps: 115/421 - (27%)

  Fly   101 EQVPE-HVMDHAPQLSRSGLLKVYVLAVMALFSLLG--NLLTIWNIYKTRISRRNSR--HTWSAI 160
            |::.| |.:..|.::|....:|:.|...:.:|.:.|  ||:.:     :|..|..||  ...|.|
 Worm    11 EELQEAHALKEAEEISEILRIKIEVCIYVIVFFIGGPLNLMAL-----SRSLRAFSRTHKAKSQI 70

  Fly   161 YSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWI 225
            ..|...|::||::..:..:..:..|..|.||...|..|:....|..||.||:::|:..|.:|| :
 Worm    71 LLLRITLNLADLMTLFLYVPKQIIWLITYQWYGGEFLCRACAFFSTFSFYLNSFVIACIAIDR-V 134

  Fly   226 AVKYPMKSLNMAK----RCHRLLGGTYILSLVLSLPQFFIFHVARGPFVE-EFYQCVT------- 278
            ...|.:.|||..:    ||..|||..::|:.:|||||..:| ....|:.. :|.||.|
 Worm   135 FGAYNISSLNAHRKAYIRCRNLLGCGWVLAFLLSLPQAVVF-TTTSPYENIDFKQCATIFMIFLH 198

  Fly   279 ------HGFYTAD---------------WQEQMYATFTLVFTFLLPLCILFGTYM---------- 312
                  |...|.|               | |:|||....:|.|.:|..::.|:|:
 Worm   199 EKRIEYHDPATTDIRREQIDEEAASMERW-EKMYAINHFLFVFWIPCIVIIGSYIVVLLILQGHL 262

  Fly   313 -----ST----FRTISS------------------------SEKMFQGSKLANYSTAKLPTQTNR 344
                 ||    ||..||                        .|:.|.....::|......:...|
 Worm   263 KQDKASTSCFNFRVKSSDIMTIDETQSTTTRSPTRSTYLLQQEESFALRSSSSYDFESHNSHPTR 327

  Fly   345 Q--------------------RLIHKAKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRL 389
            |                    ..||:||..:.|.:.:||:|:|..|:||.:..::.:|..|   :
 Worm   328 QGSIRSRASTGGGSKFGAMAVSTIHRAKQHAKRQAALIIVAYLCIWSPYNLFTVLNLFGMP---I 389

  Fly   390 GDDLQDAIFFFGMS---NSLVNPLIYGAFHL 417
            .::|:..:.|...:   |::|||:|||.|.:
 Worm   390 MEELRHFLSFLNAAICVNTVVNPIIYGVFSM 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CrzR	NP_001261755.1	7tmA_GnRHR_invertebrate	119..419	CDD:320506	100/402 (25%)
		TM helix 1	120..146	CDD:320506	6/27 (22%)
		TM helix 2	160..187	CDD:320506	6/26 (23%)
		TM helix 3	198..228	CDD:320506	10/29 (34%)
		TM helix 4	239..260	CDD:320506	11/20 (55%)
		TM helix 5	288..317	CDD:320506	12/47 (26%)
		TM helix 6	350..380	CDD:320506	10/29 (34%)
		TM helix 7	391..416	CDD:320506	9/27 (33%)
gnrr-5	NP_504228.2	TM helix 3	109..131	CDD:320504	7/21 (33%)
		TM helix 4	155..171	CDD:320504	7/15 (47%)
		TM helix 5	229..252	CDD:320504	7/22 (32%)
		TM helix 6	359..381	CDD:320504	8/21 (38%)
		TM helix 7	391..419	CDD:320504	9/27 (33%)
		7tm_GPCRs	35..420	CDD:475119	99/395 (25%)
		TM helix 1	35..58	CDD:320504	6/27 (22%)
		TM helix 2	71..94	CDD:320504	4/22 (18%)