DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CrzR and gnrr-1

DIOPT Version :9

Sequence 1:	NP_001261755.1	Gene:	CrzR / 39409	FlyBaseID:	FBgn0036278	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001249720.1	Gene:	gnrr-1 / 186230	WormBaseID:	WBGene00018798	Length:	401	Species:	Caenorhabditis elegans

Alignment Length:	295	Identity:	86/295 - (29%)
Similarity:	156/295 - (52%)	Gaps:	7/295 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 VLAVMALFSLLGNLLTIWNIYKTRISRRNSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYT 188
            ||:::..:..|..|..:.|:....|..||.......::||:.|::||.:|||...:..|....|.
Worm    20 VLSIVFTYLALFILAFVGNVTMFLILCRNQLVKVRRVHSLLLHMNIAHLLVTLVVMPKEILHNYM 84

  Fly   189 VQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLV 253
            |.|.|.::.|::.|.|.:|::.||..||:.|.:||:.::.:|:.::...|...|::...:.:|.|
Worm    85 VAWFAGDVMCRICKFFDVFAISLSMNVLICITLDRFYSIFFPLYAMRARKSVQRMVSFAWTISFV 149

  Fly   254 LSLPQFFIFHVARGPFVEEFYQCVTHGFYTADWQEQMYATFTLV---FTFLLPLCILFGTYMSTF 315
            .|.||.::|..|..|..:.:.|||:..| ..:....:...|::|   ..::.||.:....|....
Worm   150 TSAPQLYLFKTATHPCFDWYTQCVSKNF-IGELSNDVVFFFSIVNIIQVYIAPLFVTVVCYSLIL 213

  Fly   316 RTISSSEKMFQGSKLANYSTAKLPTQTNRQRLIHKAKMKSLRISVVIIIAFLICWTPYYVMMIMF 380
            ..||...|:. |.|.:..| ::|..:.|.|..:.|||.::|:::.||::||:.|||||.::|.:.
Worm   214 WRISRKSKLV-GEKESEKS-SELLLRRNGQNNLEKAKSRTLKMTFVIVLAFIFCWTPYSILMFLH 276

  Fly   381 MFLNPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAF 415
             ||.....:..|::..|:.|.:.||.::|.:||.|
Worm   277 -FLRHTDWIPKDIRKFIYAFAVLNSAISPYLYGYF 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrzR	NP_001261755.1	7tm_4	127..>260	CDD:304433	38/132 (29%)
CrzR	NP_001261755.1	7tm_1	135..412	CDD:278431	80/279 (29%)
gnrr-1	NP_001249720.1	7tmA_AKHR	21..318	CDD:320504	85/294 (29%)
		TM helix 1	23..47	CDD:320504	4/23 (17%)
		TM helix 2	57..80	CDD:320504	9/22 (41%)
		TM helix 3	95..117	CDD:320504	8/21 (38%)
		TM helix 4	138..154	CDD:320504	4/15 (27%)
		TM helix 5	187..210	CDD:320504	4/22 (18%)
		TM helix 6	249..274	CDD:320504	10/24 (42%)
		TM helix 7	286..311	CDD:320504	9/25 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5517
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368588at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X690
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.870