Protein Alignment CrzR and gnrr-7

DIOPT Version :10

• Sequence 1: NP_001261755.1
• Gene: CrzR / 39409
• FlyBaseID: FBgn0036278
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001379083.1
• Gene: gnrr-7 / 184414
• WormBaseID: WBGene00008737
• Length: 381
• Species: Caenorhabditis elegans
• Alignment Length: 414
• Identity: 82/414 - (19%)
• Similarity: 171/414 - (41%)
• Gaps: 100/414 - (24%)

  Fly    87 LAHTNSRHEAPPMAEQVPEHVMDHAPQLSRSGLLKVYVLAVMALFSLLGNLLTIWNIYKTRISRR 151
            :..|::|     :::.|||.:..   :::.:.:|.:|.:|    :.::|.::.| .:|..|..:|
 Worm     1 MIETSTR-----ISQLVPERLWS---EVTEASILFIYDIA----YIIVGFIIAI-KLYNQRKVKR 52

  Fly   152 NSRHT-WSAIYS--LMFHLSI--ADVLVTWFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSLYL 211
            ..:|. .|..::  |:|..|:  :|.::.:.....:|.|....:|....|.||:.:.:...:.:.
 Worm    53 PIQHNGQSGNHNSFLLFKTSLFASDCMIMFIYAAVKALWLLQFEWKYGSLWCKMYRYWSSVAFFS 117

  Fly   212 STYVLVLIGVDRWIAV-KYPMKSLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQ 275
            ::.::..|.:||:::| ...:..:...:|..|:|...:|::|:.:|||..::...| |..|::.|
 Worm   118 NSNIVCGIALDRYLSVYSNHIIGVRQYQRTKRMLYAVWIIALIAALPQLIVWETYR-PSSEDWEQ 181

  Fly   276 CVTHGFYTADWQE---------------QMYATFTLVFTFLLPLCILFGTYM------------- 312
            |||  .:..|..:               .:|..:.....|.|||.|...:|:
 Worm   182 CVT--VFAIDLHKLPLNSPKKDEINFCSMLYEGYHQAMAFWLPLSITIASYVRMMSRLIPFWPFT 244

  Fly   313 ----------STFRTI---SSSEK--------MFQGSKLANYSTAKLPTQTNRQRLIHKAKMKSL 356
                      .|..||   ..|||        :|:....|:..:.::|.....:.....|..:.|
 Worm   245 VLNHYEDERQQTLCTIFWSKISEKIRSFFCVTIFRRKSYASQQSVRVPLAETIRHPPTTALRRQL 309

  Fly   357 RISV-----VIIIAFLICWTPYYVMMIMFMFLNPD-----KRLGDDLQDAIFFFGMSNSLVNPLI 411
            ..:|     .||:..:|.|.||.::.:. .|:|..     .:.|.:|.:.:.   :.:|.:||::
 Worm   310 GTTVFKNACAIIVTHIILWLPYNIISLS-RFVNEGFYETISQNGGNLFELLI---LLSSFLNPIL 370

  Fly   412 YGAFHLCPGKGGKSSGGGGNNNAY 435
            |               .||.|.|:
 Worm   371 Y---------------SGGTNTAH 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CrzR	NP_001261755.1	7tmA_GnRHR_invertebrate	119..419	CDD:320506	73/364 (20%)
		TM helix 1	120..146	CDD:320506	6/25 (24%)
		TM helix 2	160..187	CDD:320506	6/30 (20%)
		TM helix 3	198..228	CDD:320506	6/30 (20%)
		TM helix 4	239..260	CDD:320506	8/20 (40%)
		TM helix 5	288..317	CDD:320506	8/66 (12%)
		TM helix 6	350..380	CDD:320506	9/34 (26%)
		TM helix 7	391..416	CDD:320506	5/24 (21%)
gnrr-7	NP_001379083.1	7tm_GPCRs	24..371	CDD:475119	72/358 (20%)
		TM helix 1	24..45	CDD:320504	5/25 (20%)
		TM helix 2	64..90	CDD:320504	4/25 (16%)
		TM helix 3	105..127	CDD:320504	2/21 (10%)
		TM helix 4	149..165	CDD:320504	5/15 (33%)
		TM helix 5	193..258	CDD:320504	8/64 (13%)
		TM helix 6	309..336	CDD:320504	8/26 (31%)
		TM helix 7	350..371	CDD:320504	5/23 (22%)