DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CrzR and gnrr-2

DIOPT Version :9

Sequence 1:	NP_001261755.1	Gene:	CrzR / 39409	FlyBaseID:	FBgn0036278	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001256583.1	Gene:	gnrr-2 / 182647	WormBaseID:	WBGene00007614	Length:	379	Species:	Caenorhabditis elegans

Alignment Length:	392	Identity:	98/392 - (25%)
Similarity:	166/392 - (42%)	Gaps:	88/392 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 STTPL--PAYAISNSSSLAHTNSRHEAPPMAEQVPEHVMDHAPQLSRSGLLKVYVLAVMALFSLL 134
            ||.|.  |...|||..:|.|..|                |:|..|         :..:.||..|.
Worm     8 STPPFINPLDEISNQETLGHVPS----------------DYAQML---------LYGIFALIGLP 47

  Fly   135 GNLLTIWNIYKTRISRRNSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTCK 199
            .|:.|:  ||..    :..||..|.:..|..:|:|:|:||....:.|...|..|::|......||
Worm    48 VNISTL--IYML----KRYRHAKSFLLLLHINLNISDILVLGLYVPGLIGWLVTLEWRGGAYLCK 106

  Fly   200 LVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMA--KRCHRLLGGTYILSLVLSLPQFFIF 262
            .::....|...:|:.::|.|.:.|..|::||: .:|..  .|..|:|...:.|::|..|||..::
Worm   107 FMRFVDAFVFAISSNIMVCIALYRLSALRYPL-WVNAVGHSRVPRMLILAWALAVVTMLPQMLVW 170

  Fly   263 HVARGPFVEEFYQCVTHGFYTADWQE----------------QMYATFTLVFTFLLPLCILFGTY 311
            :..:   .....||||      .|.|                ::|:.......|.:||.||...|
Worm   171 NEVQ---FSNITQCVT------VWTEIINKREKLSESELRNMKLYSIQNATIIFYIPLMILVACY 226

  Fly   312 M----STFRTISSSEKMFQGSKLANYSTAK-----------------LPTQTNR-QRLIHKAKMK 354
            :    ..::|:::..:....:.|:..|::|                 |.|:|.| |....:||::
Worm   227 VLILKDIYKTLNTDTECSSAAYLSEMSSSKTGGKAALHKKDQESFVTLTTRTVRGQEKFRRAKVR 291

  Fly   355 SLRISVVIIIAFLICWTPYYVMMIMFMFLNPDK-RLGDDLQDAIFFFGMSNSLVNPLIYGAFHLC 418
            ||||::::|:.:.:.|.||. ::..:|.|:.|. |...|....:....:.||::||.|||.   |
Worm   292 SLRITLLLILTYAVTWLPYN-LLSWWMVLHWDSYRENLDSNYILNSLVVLNSVINPFIYGR---C 352

  Fly   419 PG 420
            .|
Worm   353 QG 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrzR	NP_001261755.1	7tm_4	127..>260	CDD:304433	39/134 (29%)
CrzR	NP_001261755.1	7tm_1	135..412	CDD:278431	77/317 (24%)
gnrr-2	NP_001256583.1	7tm_GPCRs	38..352	CDD:391938	83/333 (25%)
		TM helix 1	38..59	CDD:341315	7/26 (27%)
		TM helix 2	67..94	CDD:341315	8/26 (31%)
		TM helix 3	105..135	CDD:341315	8/29 (28%)
		TM helix 4	147..168	CDD:341315	8/20 (40%)
		TM helix 5	193..232	CDD:341315	7/38 (18%)
		TM helix 6	287..316	CDD:341315	10/29 (34%)
		TM helix 7	328..352	CDD:341315	8/26 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368588at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24230
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X690
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020