DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CrzR and daf-38

DIOPT Version :9

Sequence 1:	NP_001261755.1	Gene:	CrzR / 39409	FlyBaseID:	FBgn0036278	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_502887.1	Gene:	daf-38 / 178443	WormBaseID:	WBGene00013642	Length:	415	Species:	Caenorhabditis elegans

Alignment Length:	458	Identity:	111/458 - (24%)
Similarity:	179/458 - (39%)	Gaps:	139/458 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 SNLSVSTTPLPAYAISNSSSLAHTNSRHEAPPMAEQVPEHVMDHAPQLSRSGLLKVYVLAVMALF 131
            |||:.||       :..|||.::.......||                  ..:|..||    .:|
Worm     5 SNLTTST-------LMTSSSESYDADNPGLPP------------------EPILSDYV----EMF 40

  Fly   132 SLLGNLLTIWNIYKTRISRRNSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANEL 196
            :|:.|.:....:.....::.:.|.|.:.:..|...|:.:|:||.:..:...|.|..|..|...:.
Worm    41 TLVLNFIVGAPLNLAAYTQLSERPTSTRLDLLKRSLNYSDLLVLFIYVPSRACWLLTYDWRGGDA 105

  Fly   197 TCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPM-KSLNMA-KRCHRLLGGTYILSLVLSLPQF 259
            .||:||:|..|:...|:.|:|.|.|||.::|..|. .|.|.| ||...:|...:|::||:|.||.
Worm   106 LCKIVKMFHTFAFQSSSNVIVCIAVDRLLSVLSPSHHSPNKALKRTKMMLIVAWIVALVISCPQL 170

  Fly   260 F------------------IFHVARGPFVEEFYQ-CVTHGFYTADWQEQMYATFTLVFTFLLPLC 305
            |                  |:.:||   :|:|.: .|...|....|    |:...:...|.:| |
Worm   171 FIWKAYLALPEYNWSQCLQIWEIAR---MEKFNKPQVVPEFDAEFW----YSILHISLVFWIP-C 227

  Fly   306 IL---------------------------FGTYMSTFRTI--SSSE----KMFQGSKLANYSTAK 337
            |:                           |.|...|..|:  .:||    |.|  |:..|....:
Worm   228 IIIMLSYIIVISWVWINSRPSIRHTSSFSFHTGCDTVDTVLTRASEWNPLKTF--SRHVNIKEPE 290

  Fly   338 LPTQTNR------------QRL--------------IHKA--------KMKSLRISVVIIIAFLI 368
            .|..|.|            ||.              :|.:        :.::||:|:::::|::|
Worm   291 KPMTTPRIVVSDETEVPLTQRPSISPSEASAVMRTGVHTSTSYNANLNRSRALRVSLLLVVAYII 355

  Fly   369 CWTPY-YVMMIMFM---FLNPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAFHLCPGKGGKSSGGG 429
            ||.|| .:.:|.|:   |.:...:.....|..|.|    ||:|||.:||.|    |....|:.|.
Worm   356 CWLPYNLISLIQFLDRDFFSSYLKHVHFCQQLIIF----NSVVNPWLYGFF----GPRRPSTTGA 412

  Fly   430 GNN 432
            |.:
Worm   413 GRH 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrzR	NP_001261755.1	7tm_4	127..>260	CDD:304433	41/134 (31%)
CrzR	NP_001261755.1	7tm_1	135..412	CDD:278431	89/368 (24%)
daf-38	NP_502887.1	7tm_1	75..399	CDD:278431	85/337 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368588at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24230
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X690
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.980