Protein Alignment CrzR and daf-38

DIOPT Version :10

• Sequence 1: NP_001261755.1
• Gene: CrzR / 39409
• FlyBaseID: FBgn0036278
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_502887.1
• Gene: daf-38 / 178443
• WormBaseID: WBGene00013642
• Length: 415
• Species: Caenorhabditis elegans
• Alignment Length: 458
• Identity: 111/458 - (24%)
• Similarity: 179/458 - (39%)
• Gaps: 139/458 - (30%)

  Fly    67 SNLSVSTTPLPAYAISNSSSLAHTNSRHEAPPMAEQVPEHVMDHAPQLSRSGLLKVYVLAVMALF 131
            |||:.||       :..|||.::.......||                  ..:|..||    .:|
 Worm     5 SNLTTST-------LMTSSSESYDADNPGLPP------------------EPILSDYV----EMF 40

  Fly   132 SLLGNLLTIWNIYKTRISRRNSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANEL 196
            :|:.|.:....:.....::.:.|.|.:.:..|...|:.:|:||.:..:...|.|..|..|...:.
 Worm    41 TLVLNFIVGAPLNLAAYTQLSERPTSTRLDLLKRSLNYSDLLVLFIYVPSRACWLLTYDWRGGDA 105

  Fly   197 TCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPM-KSLNMA-KRCHRLLGGTYILSLVLSLPQF 259
            .||:||:|..|:...|:.|:|.|.|||.::|..|. .|.|.| ||...:|...:|::||:|.||.
 Worm   106 LCKIVKMFHTFAFQSSSNVIVCIAVDRLLSVLSPSHHSPNKALKRTKMMLIVAWIVALVISCPQL 170

  Fly   260 F------------------IFHVARGPFVEEFYQ-CVTHGFYTADWQEQMYATFTLVFTFLLPLC 305
            |                  |:.:||   :|:|.: .|...|....|    |:...:...|.:| |
 Worm   171 FIWKAYLALPEYNWSQCLQIWEIAR---MEKFNKPQVVPEFDAEFW----YSILHISLVFWIP-C 227

  Fly   306 IL---------------------------FGTYMSTFRTI--SSSE----KMFQGSKLANYSTAK 337
            |:                           |.|...|..|:  .:||    |.|  |:..|....:
 Worm   228 IIIMLSYIIVISWVWINSRPSIRHTSSFSFHTGCDTVDTVLTRASEWNPLKTF--SRHVNIKEPE 290

  Fly   338 LPTQTNR------------QRL--------------IHKA--------KMKSLRISVVIIIAFLI 368
            .|..|.|            ||.              :|.:        :.::||:|:::::|::|
 Worm   291 KPMTTPRIVVSDETEVPLTQRPSISPSEASAVMRTGVHTSTSYNANLNRSRALRVSLLLVVAYII 355

  Fly   369 CWTPY-YVMMIMFM---FLNPDKRLGDDLQDAIFFFGMSNSLVNPLIYGAFHLCPGKGGKSSGGG 429
            ||.|| .:.:|.|:   |.:...:.....|..|.|    ||:|||.:||.|    |....|:.|.
 Worm   356 CWLPYNLISLIQFLDRDFFSSYLKHVHFCQQLIIF----NSVVNPWLYGFF----GPRRPSTTGA 412

  Fly   430 GNN 432
            |.:
 Worm   413 GRH 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CrzR	NP_001261755.1	7tmA_GnRHR_invertebrate	119..419	CDD:320506	97/391 (25%)
		TM helix 1	120..146	CDD:320506	6/25 (24%)
		TM helix 2	160..187	CDD:320506	7/26 (27%)
		TM helix 3	198..228	CDD:320506	13/29 (45%)
		TM helix 4	239..260	CDD:320506	8/20 (40%)
		TM helix 5	288..317	CDD:320506	8/55 (15%)
		TM helix 6	350..380	CDD:320506	10/38 (26%)
		TM helix 7	391..416	CDD:320506	10/24 (42%)
daf-38	NP_502887.1	7tm_GPCRs	36..402	CDD:475119	95/383 (25%)
		TM helix 1	38..60	CDD:410628	3/21 (14%)
		TM helix 2	70..93	CDD:410628	5/22 (23%)
		TM helix 3	108..130	CDD:410628	9/21 (43%)
		TM helix 4	153..169	CDD:410628	5/15 (33%)
		TM helix 5	212..236	CDD:410628	6/28 (21%)
		TM helix 6	343..365	CDD:410628	9/21 (43%)
		TM helix 7	379..402	CDD:410628	10/26 (38%)