Protein Alignment CrzR and Ffar4

DIOPT Version :10

• Sequence 1: NP_001261755.1
• Gene: CrzR / 39409
• FlyBaseID: FBgn0036278
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_861413.1
• Gene: Ffar4 / 107221
• MGIID: 2147577
• Length: 361
• Species: Mus musculus
• Alignment Length: 340
• Identity: 78/340 - (22%)
• Similarity: 143/340 - (42%)
• Gaps: 62/340 - (18%)

  Fly   104 PEHVMD-----HAPQLSR--------SGLLKVYVLAVMALFSLLGNLLTIWNIYKTRISRRNSRH 155
            |.|.:|     |.|..|.        ..:::..||.::.:.|||||:..:     ..::||..|
Mouse    13 PSHTLDQVNRTHFPFFSDVKGDHRLVLSVVETTVLGLIFVVSLLGNVCAL-----VLVARRRRR- 71

  Fly   156 TWSAIYSLMFHLSIADVLVT-WFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSLYLSTYVLVL- 218
              .|..||:.:|..||:|.| ...::....|  |..||...:.|.|  ||.:.::..|..:|.|
Mouse    72 --GATASLVLNLFCADLLFTSAIPLVLVVRW--TEAWLLGPVVCHL--LFYVMTMSGSVTILTLA 130

  Fly   219 -IGVDRWIAVKYPMKSLNMAKRCHR--LLGGTYILSLVLSLPQFFIFHVA--RGP-FVEEFYQCV 277
             :.::|.:.:....:.|:...|..:  ||...:..|.:.:||...:|.|.  |.| ..:|...|
Mouse   131 AVSLERMVCIVRLRRGLSGPGRRTQAALLAFIWGYSALAALPLCILFRVVPQRLPGGDQEIPIC- 194

  Fly   278 THGFYTADWQEQM----YATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKLANYSTAKL 338
                 |.||..::    :..|.:...||:|..::..:|....:...:|.|..         |..|
Mouse   195 -----TLDWPNRIGEISWDVFFVTLNFLVPGLVIVISYSKILQITKASRKRL---------TLSL 245

  Fly   339 PTQTNRQRLIHKAKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLNPDKRLGDDL--QDAIFF-- 399
            ....:.|..:.:...:..|...:::::|.|.|:|..:.:::.:..|    ...||  ..::||
Mouse   246 AYSESHQIRVSQQDYRLFRTLFLLMVSFFIMWSPIIITILLILIQN----FRQDLVIWPSLFFWV 306

  Fly   400 --FGMSNSLVNPLIY 412
              |..:||.:||::|
Mouse   307 VAFTFANSALNPILY 321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CrzR	NP_001261755.1	7tmA_GnRHR_invertebrate	119..419	CDD:320506	72/312 (23%)
		TM helix 1	120..146	CDD:320506	7/25 (28%)
		TM helix 2	160..187	CDD:320506	8/27 (30%)
		TM helix 3	198..228	CDD:320506	8/31 (26%)
		TM helix 4	239..260	CDD:320506	6/22 (27%)
		TM helix 5	288..317	CDD:320506	5/32 (16%)
		TM helix 6	350..380	CDD:320506	5/29 (17%)
		TM helix 7	391..416	CDD:320506	10/28 (36%)
Ffar4	NP_861413.1	7tm_classA_rhodopsin-like	43..321	CDD:410626	71/308 (23%)
		TM helix 1	43..67	CDD:410626	7/28 (25%)
		TM helix 2	74..99	CDD:410626	7/24 (29%)
		TM helix 3	111..141	CDD:410626	8/31 (26%)
		TM helix 4	154..173	CDD:410626	4/18 (22%)
		TM helix 5	204..229	CDD:410626	5/24 (21%)
		TM helix 6	257..290	CDD:410626	5/32 (16%)
		TM helix 7	301..321	CDD:410626	7/19 (37%)